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8 results for “mammary gland hyperplasia”
Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia
<p class="MsoNormal"><strong><span>Background</span></strong><span>: In recent years, Mammary gland hyperplasia (MGH) </span><span>has been</span><span> considered to be one of the diseases caused by endocrine disorders. It has been shown that diseases caused by endocrine disorders can be treated by regulating intestinal microbial. As a commonly used medicine in clinical practice, <em>Atractylodes </em></span><em><span>M</span></em><em><span>acrocephala Rhizoma</span></em><span> has good functions in regulating intestinal homeostasis. Therefore, this paper studied the effect of <em>Atractylodes </em></span><em><span>M</span></em><em><span>acrocephala Rhizoma</span></em><span> polysaccharide (AMP), on the intestinal flora of MGH rats, providing a new idea for polysaccharide treatment of MGH.</span></p> <p class="MsoNormal"><strong><span>Materials and methods</span></strong><span>: </span><span>Eighteen</span><span> female SD rats were selected and randomly divided into three groups, blank control group (Con), model control group (Mod) and AMP group, six rats in each group. MGH rat models were established by estradiol-progesterone combination and treated with AMP gastric infusion. The levels of E<sub>2</sub>, P and PRL in the serum of rats were measured, the intestinal contents were collected, and 16s rRNA high-throughput sequencing technology was used to analyze the changes of intestinal flora in the MGH rats.</span></p> <p class="MsoNormal"><strong><span>Results</span></strong><span>: AMP has good therapeutic effects on MGH rats, decreasing estradiol (E<sub>2</sub>) and prolactin (PRL) levels and increasing progesterone (P) levels, at the same time, it can regulate the abundance and diversity of intestinal flora of MGH rats, improve the disorder of intestinal flora caused by MGH </span><span>and </span><span>change the community structure, increase the abundance of beneficial flora and decrease the abundance of pathogenic flora.</span></p> <p class="MsoNormal"><strong><span>Conclusion</span></strong><span>: AMP can improve the intestinal microbiological environment of MGH rats, maintain the microecological balance of intestinal microbial</span><span>, and improve MGH symptoms</span><span>.</span></p>
Construction of microneedle of Atractylodes macrocephala aqueous extract and effect on mammary gland hyperplasia based on intestinal flora
<p><strong><span>Background</span></strong><span>: </span><span>A </span><span>microneedle</span><span> patch loaded with <em>Atractylodes macrocephala</em> water extract was prepared for the treatment of mammary gland hyperplasia to explore the relationship between MGH and intestinal flora. </span></p> <p><strong><span>Materials and methods</span></strong><span>: </span><span>Preparation of the microneedle patch by micromolding method, the prescription of the microneedle was optimized by the Box-Behnken Design response surface test, and the micro-morphology, penetration, toughness, and brittleness were investigated. <em>In vitro</em> release of drug-loaded microneedles was measured by diffusion cell method. The rat model of mammary gland hyperplasia was prepared by the combination of estradiol benzoate-progesterone, and the microneedle patch of <em>Atractylodes macrocephala</em> aqueous extract was used for intervention treatment. The change of levels in E<sub>2</sub>, P, and PRL in rat serum was determined. The intestinal contents of rats were collected and the changes in intestinal flora in MGH rats were analyzed by 16s rRNA high-throughput sequencing. </span></p> <p><strong><span>Results</span></strong><span>: </span><span>The optimized microneedle formula is a PVA concentration of 6.0%, HA concentration of 15.5%, and PVPK30 concentration of 16.0%. The prepared microneedle tip loaded with <em>Atractylodes macrocephala</em> aqueous extract has complete, sharp, and no bubbles and the needle rate of the microneedle array is in the range of 95%~100%. The bending rate of the microneedle is about 12.7%, and it has good flexibility, and the microneedle can puncture 4 layers of Parafilm</span><span>Ⓡ</span><span> membrane smoothly, and the puncture rate is more than 96%. The <em>in vitro</em> release of the microneedle was characterized by rapid release. The results of animal experiments showed that <em>Atractylodes macrocephala</em> aqueous extract microneedle patch could significantly reduce the E<sub>2</sub> level, significantly reduce the PRL level, and significantly increase the P level. At the same time, it can regulate the abundance and diversity of intestinal flora in MGH rats, improve the intestinal flora disorder caused by mammary gland hyperplasia, and balance the community structure. </span></p> <p><strong><span>Conclusion</span></strong><span>: </span><span>The prepared microneedle containing <em>Atractylodes macrocephala</em> aqueous extract has good toughness and brittle strength, can penetrate the skin and enter the dermis, and effectively deliver drugs to play a role in the treatment of mammary gland hyperplasia.</span></p>
Construction of microneedle of Atractylodes macrocephala aqueous extract and effect on mammary gland hyperplasia based on intestinal flora
Open the record for dataset details and reuse information.
Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia
Open the record for dataset details and reuse information.
Study Into Treatment of Hyperplasia of Mammary Glands
ClinicalTrials.gov study NCT02505256. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Xiangjurupining Capsule for Hyperplasia of Mammary Glands
ClinicalTrials.gov study NCT06685978. IPD Sharing: NO. Countries: 1. Publications: 0.
A Clinical Study on the Efficacy and Safety of the Treatment of Hyperplasia of Mammary Glands With Xiaoru Sanjie Capsule
ClinicalTrials.gov study NCT02929420. IPD Sharing: YES. Countries: 1. Publications: 0.
Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA but does not affect mammary tumor latency, gene expression or signaling
GEO Series GSE43037. Mus musculus. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.