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Dataset results
11 results for “mechanobiology”
Wide-range viscoelastic compression forces in microfluidics to probe cell-dependent nuclear structural and mechanobiological responses
<p><span>The cell nucleus plays a critical role in mechanosensing and mechanotransduction processes, by adaptive changes of its envelope composition to external biophysical stimuli such as substrate rigidity and tensile forces. Current measurement approaches lack of precise control in stress application on nuclei, thus significantly impairing a complete mechanobiological study of cells. Here, we present a contactless microfluidic approach capable to exert a wide-range of viscoelastic compression forces (10-103 </span>μ<span>N) -as an alternative to adhesion-related techniques- to induce cell-specific mechano-structural and biomolecular changes. We succeed in monitoring substantial nuclear modifications in Lamin A/C expression and coverage, diffusion processes of probing molecules, YAP shuttling, chromatin re-organization and cGAS pathway activation. As a result, high compression forces lead to a nuclear reinforcement (e.g. up to +20% in Lamin A/C coverage) or deconstruction (e.g. down to -45% in Lamin A/C coverage with a 30% reduction of chromatin condensation state parameter) up to cell death. We demonstrate how wide-range compression on suspended cells can be used as a tool to investigate nuclear mechanobiology and to define specific nuclear signatures for cell mechanical phenotyping. </span></p>
IL-3 receptor signaling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells
<p>RNA from unchallenged mouse <em>Il3r</em><sup>-/-</sup> and <em>Il3r</em><sup>+/+</sup> thymocytes was isolated with the NucleoSpin RNA Kit for RNA isolation (Machery Nagel). RNA-Analysis and sequencing was performed by the Core unit next generation sequencing of the University Hospital Erlangen. The quality of isolated RNA was determined using an Agilent 2100 bioanalyzer with RNA 6000 Nano kit and related software (Agilent). Sequencing libraries were generated from RNA samples using the TruSeq Stranded mRNA Kit (Illumina). Libraries were sequenced on a HiSeq 2500 platform (Illumina). The reads were aligned with Star v2.5.4b against the GRCm38 reference genome. Reads were counted with featureCounts of the Rsubread package v2.8.1.</p>
The Effect of Corrective Osteotomy on in Vivo Cartilage Mechanobiology in Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT02622204. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Wide-range viscoelastic compression forces in microfluidics to probe cell-dependent nuclear structural and mechanobiological responses
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IL-3 receptor signaling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells
GEO Series GSE235520. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A Master Protocol Empowering Mechanobiology Translation Research in Breast Cancer
ClinicalTrials.gov study NCT04625023. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair
ClinicalTrials.gov study NCT05505747. IPD Sharing: NO. Countries: 1. Publications: 0.
Mechanobiological proximal tubular defects in ARC syndrome: A VPS33B CRISPR knockout study
GEO Series GSE298726. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Mechanobiological stimulation in organ-on-a-chip systems reduces hepatic drug metabolic capacity in favor of regenerative specialization
GEO Series GSE218054. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Heart-on-a-chip: A Novel Microfluidic Approach to Organ Modelling and Cellular Mechanobiology
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A high-risk osteoarthritis mutation in COL6A3 alters the mechanobiologic response of chondrocytes derived from human induced pluripotent stem cells
GEO Series GSE293777. Homo sapiens. 84 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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