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32 results for “medicine quality”
ValRun: GMP-grade Manufacturing and Quality Control of a Non-Virally engineered Advanced Therapy Medicinal Product for Personalized Treatment of Age-Related Macular Degeneration
<p><strong>VaLRun: </strong></p> <p><strong>Raw data of "GMP-grade Manufacturing and Quality Control of a Non-Virally engineered Advanced Therapy Medicinal Product for Personalized Treatment of Age-Related Macular Degeneration"</strong></p> <p>(Excel-, pdf-, GraphPad-files, mp4 videos and a READ-ME text file)</p> <p>The introduction of new therapeutics requires validation of Good Manufacturing Practice (GMP)-grade manufacturing including suitable quality controls. This is challenging for Advanced Therapy Medicinal Products (ATMP) with personalized batches. We have developed a person-alized, cell-based gene therapy to treat age-related macular degeneration and established a vali-dation strategy of the GMP-grade manufacture for the ATMP; manufacturing and quality control were challenging due to a low cell number, batch-to-batch variability and short production duration. Instead of patient iris pigment epithelial cells, human donor tissue was used to produce the transfected cell product (“tIPE”). We implemented an extended validation of 104 tIPE productions. Procedure, operators and devices have been validated and qualified by determining cell number, viability, extracellular DNA, sterility, duration, temperature and volume. Transfected autologous cells were transplanted to rabbits verifying feasibility of the treatment. A container has been engineered to insure a safe transport from the production to the surgery site. Criteria for successful validation and qualification were based on tIPE’s Critical Quality Attributes and Process Parameters, its manufacture and release criteria. The validated process and qualified operators are essential to bring the ATMP into clinic and offer a general strategy for the transfer to other manufacture centers and personalized ATMPs.</p>
Complementary and Alternative Medicine Use and its Impact on Quality of Life among Cancer Patients in Freetown, Sierra Leone: Considerations for a Resource-Limited Setting
<p> </p> <p><span>Cancer patients are increasingly resorting to complementary and alternative medicine (CAM) to alleviate the effects of the disease and enhance their quality of life (QoL). However, to our knowledge, no study has investigated CAM use and its impact on QoL in patients with cancer in Sierra Leone. Therefore, this study aimed to assess the prevalence of and associated factors with CAM use, and compare the quality of life between CAM users and non-users.</span></p> <p><span>This cross-sectional descriptive study was conducted at three health facilities in Freetown viz Connaught Hospital Ola During Children's Hospital, and the Water and Stone Clinic. Data were collected through face-to-face interviews, using an adapted questionnaire. The QoL was assessed using the European Organization for Research and Treatment of Cancer tool. Descriptive analysis was employed, and binary logistic regression tests were used to explore the associated factors of CAM use, with statistical significance set at p<0.05.</span></p> <p><span>In total, 204 participants completed the study. The prevalence of CAM use was 48.5%. Among the various CAMs examined in this study, herbal medicines (48.8%) followed by special foods (19.4%) were the most commonly used forms of CAM. The primary reason for CAM use was the management of cancer complications (43.4%). Over half of the CAM users did not disclose their CAM use to their doctors (53.5%). There was a statistically significant association between CAM use and tertiary education (AOR=2.68, 95%CI=1.31-5.49, p=0.007) and chemotherapy treatment (AOR=1.91, 95%CI= 1.06-3.46, p=0.032). There was no considerable impact of CAM on QoL, although financial difficulty was statistically significant among CAM users compared with non-CAM users.</span></p> <p><span>This study revealed that CAM use is prevalent among cancer patients, with herbal medicines being the most commonly used form, followed by special foods and prayers. <span> </span>Patients primarily obtain information about CAM from family, friends, and relatives, and most do not discuss CAM use with their doctors. Tertiary education and chemotherapy were found to be predictors of CAM use. Regarding the impact of CAM on QoL, only financial difficulty was statistically significant.</span></p>
Quality of life among Romanian Emergency Medicine Personnel during the COVID-19 Pandemic and the Russian–Ukrainian Armed Conflict
<p>The aim of the present study was to investigate the relationship between threat perception and professional quality of life in a sample of Emergency Medicine Personnel, during the COVID-19 pandemic and during the outbreak of the Russian-Ukrainian Armed Conflict. Two types of threats were investigated (war threat and pandemic threat) and three indicators of professional quality of life (i.e., secondary traumatic stress, burnout, and compassion satisfaction). The mediating role of worries in the relationship between threat perception and quality of life was also assessed. </p>
Impact of Acupuncture and Integrative Medicine on Patients Quality-of-life During National Emergency and Wartime
ClinicalTrials.gov study NCT06604455. IPD Sharing: NO. Countries: 1. Publications: 1.
Reducing Structural Inequities in Heart Failure Management: An Approach to Improve the Quality of Heart Failure Care on the General Medicine Service: Longitudinal Equity Action Plan (LEAP)
ClinicalTrials.gov study NCT03942978. IPD Sharing: NO. Countries: 1. Publications: 10.
The Effect of Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults
ClinicalTrials.gov study NCT06157385. IPD Sharing: UNDECIDED. Countries: 1. Publications: 23.
Effect of a Competence Based Medical Education Programme on Training Quality in Intensive Care Medicine.
ClinicalTrials.gov study NCT04278976. IPD Sharing: NO. Countries: 1. Publications: 24.
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Hea
ClinicalTrials.gov study NCT04212390. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Mind-Body Medicine for the Improvement of Quality of Life in Adolescents and Young Adults Coping With Lymphoma
ClinicalTrials.gov study NCT04270266. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults
ClinicalTrials.gov study NCT05593978. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
IDOMENEO - Is Treatment Reality in Vascular Medicine Evidence-based and Follows Guideline Recommendations? A Project for Quality Development Exemplified by Peripheral Arterial Disease (PAD)
ClinicalTrials.gov study NCT03098290. IPD Sharing: UNDECIDED. Countries: 1. Publications: 16.
Quality Improvement in Handover of General Internal Medicine In-patients
ClinicalTrials.gov study NCT01796756. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Virtual Autopsy for Quality Control on Intensive Care Medicine
ClinicalTrials.gov study NCT01541982. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Health-related Quality of Life-intervention in Survivors of Breast and Other Cancers Experiencing Cancer-related Fatigue Using Traditional Chinese Medicine: The HERBAL Trial
ClinicalTrials.gov study NCT04104113. IPD Sharing: NO. Countries: 1. Publications: 2.
Traditional Chinese Medicine JianPiHuaTan Formula Improving Quality of Life and Survival in Patients with Colorectal Cancer through RAS/RAF Downstream Signaling Pathways
GEO Series GSE269502. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
A high-quality chromosome-level genome assembly of the traditional Chinese medicinal herb Zanthoxylum nitidum
GEO Series GSE281536. Zanthoxylum nitidum. 21 samples. Type: Expression profiling by high throughput sequencing.
Effect of Homeopathy, Acupuncture or Anthroposophic Medicine in Women's Quality of Life
ClinicalTrials.gov study NCT02504515. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prevalence and Subjective Impairment of Quality of Life (QoL) Due to Dermatologic Diseases in Internal Medicine Patients
ClinicalTrials.gov study NCT01044043. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Traditional Chinese Medicine Five Elements Music Therapy Improving Quality of Life in Patients With Advanced Cancer
ClinicalTrials.gov study NCT00964314. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Non-inferiority Trials of the Quality of Nurse Consultation Versus a Medical Consultation in Travel Medicine.
ClinicalTrials.gov study NCT03274180. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.