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12
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ShareScore release 0.9.0
Dataset results
12 results for “membrane damage”
Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
The central nervous system (CNS) insults may cause massive demyelination and lead to the release of myelin-associated proteins including its major component myelin basic protein (MBP). MBP is reported to induce glial activation but its effect on neurons is still little known. Here we found that MBP specifically bound to the extracellular surface of the neuronal plasma membrane and induced neurotoxicity in vitro. This effect of MBP on neurons was basicity-dependent because the binding was blocked by acidic lipids and competed by other basic proteins. Further studies revealed that MBP induced damage to neuronal membrane integrity and function by depolarizing the resting membrane potential, increasing the permeability to cations and other molecules, and decreasing the membrane fluidity. At last, artificial liposome vesicle assay showed that MBP directly disturbed acidic lipid bilayer and resulted in increased membrane permeability. These results revealed that MBP induces neurotoxicity through its direct interaction with acidic components on the extracellular surface of neuronal membrane, which may suggest a possible contribution of MBP to the pathogenesis in the CNS disorders with myelin damage.
How Do Xanthophylls Protect Lipid Membranes from Oxidative Damage?
<p><span>equatorial optical cross-sections of liposomes recorded with the FLIM technique<br></span></p>
Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
Open the record for dataset details and reuse information.
Time-resolved miRNA-mRNA integrated analysis reveals the miRNA-mRNA networks underlying plasma membrane damage-dependent senescence and DNA damage response-dependent senescence in WI-38 normal human f
GEO Series GSE299871. Homo sapiens. 36 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Innate immune and metabolic signaling retain damaged mitochondria at cell membranes for mitoxyperilysis
GEO Series GSE235046. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Senescence progression in the normal human fibroblast, WI-38 cells induced with plasma membrane damage, calcium influx, DNA damage and telomere shortening.
GEO Series GSE222400. Homo sapiens. 52 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA-seq of airspace cellular subsets after inflammation and membrane damage
GEO Series GSE174414. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of carboxylic acid challenge in Escherichia coli: beyond membrane damage
GEO Series GSE53140. Escherichia coli; Escherichia coli str. K-12 substr. MG1655. 5 samples. Type: Expression profiling by array.
The Improvement of Limbal Stem Cell Deficiency (LSCD) in Unilateral Stem Cell Damage by Amniotic Membrane Extract Eye Drop (AMEED)
ClinicalTrials.gov study NCT02649621. IPD Sharing: NO. Countries: 0. Publications: 0.
Immunostimulatory effects of Streptococcus sanguinis extracellular membrane vesicles protect oral gingival epithelial cells from periodontal pathobiont damage
GEO Series GSE288367. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
CHIP protects lysosomes from CLN4 mutant-induced membrane damage
GEO Series GSE302082. Homo sapiens. 8 samples. Type: Other.
Codonopsis pilosula polysaccharides mitigates Brucella abortus outer membrane protein 19-induced uterine damage via macrophage adhesion and calcium signaling
GEO Series GSE314097. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.