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Dataset results
64 results for “memory consolidation”
Temporal cluster-based organisation of sleep spindles underlies motor memory consolidation
<p><span>Sleep benefits motor memory consolidation, which is mediated by sleep spindle activity and associated memory reactivations during non-rapid eye movement (NREM) sleep. However, the particular role of NREM2 and NREM3 sleep spindles and the mechanisms triggering this memory consolidation process remai<span>n unclear. Here, sim</span>ultaneous electroencephalographic and functional magnetic resonance imaging (EEG-fMRI) recordings were collected during night-time sleep following the learning of a motor sequence task. Adopting a time-based clustering approach, we provide evidence that spindles iteratively occur within clustered and temporally organised patterns during both NREM2 and NREM3 sleep. However, the clustering of spindles in trains is related to motor memory consolidation during NREM2 sleep only</span><span>. Altogether</span><span>,</span><span> our findings suggest t</span><span>hat</span><span> spindles' clustering and </span><span>rhythmic occurrence </span><span>during NREM2 sleep may serve as an intrinsic rhythmic sleep mechanism for the timed reactivation and subsequent consolidation of motor memories, through synchronised oscillatory activity within a subcortical-cortical network involved during learning</span>.</p>
Dataset for manuscript "Prefrontal stimulation as a tool to disrupt hippocampal and striatal reactivations underlying fast motor memory consolidation"
<p>Dataset containing the source data corresponding to figures and tables in the manuscript "Prefrontal stimulation as a tool to disrupt hippocampal and striatal reactivations underlying fast motor memory consolidation", as well as raw behavioral and MEP data and the corresponding analysis scripts.</p>
Resting-state fMRI data for locating causal hubs of memory consolidation in spontaneous brain network
<p>The mouse fMRI data for the paper "<strong>Locating causal hubs of memory consolidation in spontaneous brain network in male mice</strong>"<strong> </strong>published in <strong>Nature Communications </strong>(DOI: 10.1038/s41467-023-41024-z)<strong>. </strong>This includes longitudinal resting-state fMRI data in mice after behavioural training for 1-Day or 5-Day Active Place Avoidance (APA) task, acquired at post-training day 1 and day 8. Due to the large datasets, each group has been packed into several 2GB zip files. They need to be downloaded into the same folder and unpacked together (e.g. 1-Day APA Post training day 1 has five zip files starting with "1DAPA_PostDay1"). The structural and EPI templates and the ROI labels in the AMBMC atlas space are provided in the AMBMC_label.zip. </p>
Temporal cluster-based organisation of sleep spindles underlies motor memory consolidation
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Impact of background input on memory consolidation in In-Vitro neural networks
<p>Memory consolidation is a complex process, that can be divided into two stages: first, memories are temporary stored in hippocampus and in the second stage, repeated replay slowly transfers memories to the neo-cortex for long-term consolidation. This 2<sup>nd</sup> stage occurs during slow wave sleep, a phase characterized in the cortex by low cholinergic tone and low afferent input. A recent in-vitro study showed that high cholinergic tone hampers memory consolidation, probably due to lowered network excitability (defined as the mean network response to one neuron spiking). Here we investigate whether low background input contributes to memory consolidation.</p> <p>We used cortical neuronal networks on multi electrode arrays to study memory. When input deprived, these networks develop an activity-connectivity balance. Focal stimuli initially disrupt the existing balance, inducing connectivity changes. When repeated, this effect fades and the response becomes part of spontaneous patterns (memory formation). Application of the same stimulus hours later does not affect connectivity indicating that memory was consolidated.</p> <p>We applied five periods (10 min each) of focal electrical stimulation at different electrodes (A B A), separated by 1 hour of spontaneous activity . Some cultures were transfected to express channelrhopsins (ChR2) enabling global optogenetic background stimulation. We used 12 control, 15 ChR2 cultures with no background input and 8 ChR2 cultures with superimposed random optogenetic stimulation during electrical stimulation periods (f<sub>mean</sub>=5 Hz) to mimic afferent input.</p> <p>Background stimulation acutely reduced network excitability during stimulation without persisting effects after cessation. ChR2 cultures showed significantly more dispersed spiking outside network bursts, and network excitability tended to be lower than in control cultures. Stimulation at electrodes A and B induced memory traces in control cultures. Return to electrode A did not further affect connectivity, showing that memory trace A had been consolidated. Background stimulation impeded the formation of memory traces following electrical stimulation at either electrode. ChR2 expression alone also obstructed memorization.</p> <p>These findings confirm the importance of low background afferent input for memory consolidation. The presence of background afferent inputs reduced network excitability, similar to high cholinergic tone. This leads to the conclusion that sufficient network excitability is crucial for memory consolidation, and high network excitability may be a critical feature of slow wave sleep that makes it more suitable for memory consolidation than the awake state.</p>
Dataset for manuscript "Sleep does not influence schema-facilitated motor memory consolidation"
<p>Dataset containing the raw as well as the subject-level data for the two experiments reported in the manuscript "Sleep does not influence schema-facilitated motor memory consolidation".</p>
Impact of background input on memory consolidation in In-Vitro neural networks
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Acute Exercise and Motor Memory Consolidation: The Role of Exercise Intensity
<p>A single bout of high intensity aerobic exercise (~90% VO<sub>2peak</sub>) was previously demonstrated to amplify off-line gains in skill level during the consolidation phase of procedural memory. High intensity exercise is not always a viable option for many patient groups or in a rehabilitation setting where low to moderate intensities may be more suitable. The aim of this study was to investigate the role of intensity in mediating the effects of acute cardiovascular exercise on motor skill learning. A single bout of high intensity aerobic exercise (~90% VO<sub>2peak</sub>) was previously demonstrated to amplify off-line gains in skill level during the consolidation phase of procedural memory. High intensity exercise is not always a viable option for many patient groups or in a rehabilitation setting where low to moderate intensities may be more suitable. The aim of this study was to investigate the role of intensity in mediating the effects of acute cardiovascular exercise on motor skill learning.</p>
Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Patients With Mild Cognitive Impairment
ClinicalTrials.gov study NCT01782365. IPD Sharing: Not stated. Countries: 1. Publications: 10.
The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories
ClinicalTrials.gov study NCT03031405. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Autonomic Mechanisms of Sleep-dependent Memory Consolidation
ClinicalTrials.gov study NCT04021797. IPD Sharing: NO. Countries: 1. Publications: 8.
26 Weeks' Dietary Supplementation With DHA- and EPA-enriched Oils on Memory Consolidation in Healthy Adults
ClinicalTrials.gov study NCT03592251. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
ClinicalTrials.gov study NCT01840839. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Triggering Motor Memory Consolidation in PD: Complex Practice of Fine Motor Tasks and Brain Activity During Learning
ClinicalTrials.gov study NCT04269590. IPD Sharing: NO. Countries: 1. Publications: 3.
The Impact of Glycemic Index on Sleep and Memory Consolidation
ClinicalTrials.gov study NCT05591573. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation
ClinicalTrials.gov study NCT05726045. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Brain Stimulation During Daytime Nap on Memory Consolidation in Younger, Healthy Subjects
ClinicalTrials.gov study NCT01840865. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Patients With Mild Cognitive Impairments
ClinicalTrials.gov study NCT01782391. IPD Sharing: Not stated. Countries: 1. Publications: 5.
The Effect of Oxytocin on the Consolidation of Trauma-Associated Memories
ClinicalTrials.gov study NCT03875391. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Modulation of Memory Consolidation in Humans
ClinicalTrials.gov study NCT04714879. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.