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205 results for “memory function”
Differentiation of functional networks during long-term memory retrieval in children and adolescents
Open the record for dataset details and reuse information.
Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells
<p>Skin-resident CD8+ T cells comprise distinct IFN-γ- (TRM1) and IL-17-producing (TRM17) subsets that differentially contribute to immune responses. However, whether these populations employ common mechanisms to establish tissue residence is unknown. Here, we show that TRM1 and TRM17 cells navigate divergent trajectories to acquire tissue residency in skin. While TRM1 cells depend on a T-bet-Hobit-IL-15 axis, TRM17 cells develop independently of these factors. Instead, c-Maf commands a tissue-resident program in TRM17 cells parallel to that induced by Hobit in TRM1 cells, with an ICOS-c-Maf-IL-7 axis pivotal to TRM17 cell commitment. Accordingly, targeting this pathway enables ablation of skin TRM17 cells without compromising their TRM1 counterparts. Thus, skin-resident T cells rely on distinct molecular circuitries, which can be exploited to strategically modulate local immunity.</p>
Dataset for: Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion
<p>The brain must guide immediate responses to beneficial and harmful stimuli while simultaneously writing memories for future reference. While both immediate actions and reinforcement learning are instructed by dopamine, how dopaminergic systems maintain coherence between these two reward functions is unknown. Through optogenetic activation experiments, we showed that the dopamine neurons that inform olfactory memory in Drosophila have a distinct, parallel function driving attraction and aversion (valence). Sensory neurons required for olfactory memory were dispensable to dopaminergic valence. A broadly projecting set of dopaminergic cells had valence that was dependent on dopamine, glutamate, and octopamine. Similarly, a more restricted dopaminergic cluster with attractive valence was reliant on dopamine and glutamate; flies avoided opto-inhibition of this narrow subset, indicating the role of this cluster in controlling ongoing behavior. Dopamine valence was distinct from output-neuron opto-valence in locomotor pattern, strength, and polarity. Overall our data suggest that dopamine’s acute effect on valence provides a mechanism by which a dopaminergic system can coherently write memories to influence future responses while guiding immediate attraction and aversion.</p>
Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells
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Data from: The presubiculum links incipient amyloid and tau pathology to memory function in older persons
Objective: To identify the hippocampal subregions linking initial amyloid and tau pathology to memory performance in clinically normal older individuals, reflecting preclinical Alzheimer's disease (AD). Methods: A total of 127 individuals from the Harvard Aging Brain Study (Mean age: 76.22 years ± 6.42, 68 females (53.5%)) with a Clinical Dementia Rating score of 0, a flortaucipir tau-PET scan, a Pittsburgh Compound B amyloid-PET scan, a structural MRI scan and cognitive testing were included. From these images, we calculated neocortical, hippocampal and entorhinal amyloid pathology, entorhinal and hippocampal tau pathology and the volumes of six hippocampal subregions and total hippocampal volume. Memory was assessed with the selective reminding test. Mediation and moderation analyses modeled associations between regional markers and memory. Analyses included covariates for age, sex and education. Results: Neocortical amyloid, entorhinal tau and presubiculum volume univariately associated with memory performance. The relationship between neocortical amyloid and memory was mediated by entorhinal tau and presubiculum volume, which was modified by hippocampal amyloid burden. With other biomarkers held constant, presubiculum volume was the only marker predicting memory performance in the total sample and in individuals with elevated hippocampal amyloid burden. Conclusions: The presubiculum captures unique AD-related biological variation that is not reflected in total hippocampal volume. Presubiculum volume may be a promising marker of imminent memory problems, and can contribute to understanding the interaction between incipient AD-related pathologies and memory performance. The modulation by hippocampal amyloid suggests that amyloid is a necessary process – but not sufficient – to drive neurodegeneration in memory-related regions.
Physical Activity is Associated with Reduced Implicit Learning but Enhanced Relational Memory and Executive Functioning in Young Adults
<p>This file contains all data reported in the main analyses of our paper, including age, gender, BMI, Stroop effect, implicit learning sessions 1 and 2, relational memory, and all physical activity variables</p>
Causal functional maps of brain rhythms in working memory
<p>Results of the meta-modeling of transcranial alternating current stimulation (tACS) studies in working memory. Two files are for theta and gamma maps in MNI brain space. The files accompany the paper "Causal functional maps of brain rhythms in working memory" by Miles Wischnewski*, Taylor A Berger, Alexander Opitz, and Ivan Alekseichuk**. Correspondance: *m.wischnewski@rug.nl or **ialeksei@umn.edu</p> <p> </p>
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
ClinicalTrials.gov study NCT01044758. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Data from: The presubiculum links incipient amyloid and tau pathology to memory function in older persons
Open the record for dataset details and reuse information.
Memory tracing, profiling and autotuning for containerised cloud functions
<p>This dataset contains CSV files with the raw measurements of 4x10 traces as well as scripts and reference data for distinguishing two usage profiles based on raw measurements of 2x20 traces. It accompanies the publication «Resource Management for Cloud Functions with Memory Tracing, Profiling and Autotuning» presented at WoSC6 @ Middleware 2020.</p>
Data from: Incorporating animal spatial memory in step selection functions
Memory is among the most important and neglected forces that shapes animal movement patterns. Research on the movement-memory interface is crucial to understand how animals use spatial learning to navigate across space because memory-biased navigation is directly linked to animals' space use and home range behaviour; however, because memory cannot be measured directly, it is difficult to account for. Here, we incorporated spatial memory into Step Selection Functions (SSF) to understand how resource selection and spatial memory affect space use of feral hogs (Sus scrofa). We used Biased Random Bridge kernel estimates linked to residence time as a surrogate for memory and tested four conceptually different dynamic maps of spatial memory. We applied this memory-based SSF to a data set of hog relocations to evaluate the importance of land cover type, time of day, and spatial memory on the animals' space use. Our approach has shown how the incorporation of spatial memory into animal movement models can improve estimates of habitat selection. Memory-based SSF provided a feasible way to gain insight into how animals use spatial learning to guide their movement decisions. We found that while hogs selected forested areas and water bodies and avoided grasslands during the day (primarily at noon), they had a strong tendency to select previously visited areas, mainly those held in recent memory. Beyond actively updating their memory with recent experiences, hogs were able to discriminate among spatial memories encoded at different circadian phases of their activity. Even though hogs are thought to have long memory retention, they likely relied on recent experiences because the local food resources are quickly depleted and slowly renewed, yielding an uncertain spatial distribution of resources.
Data from: Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3
Much of the research on cannabinoids (CBs) has focused on their effects at the molecular and synaptic level. However, the effects of CBs on the dynamics of neural circuits remains poorly understood. This study aims to disentangle the effects of CBs on the functional dynamics of the hippocampal Schaffer collateral synapse by using data-driven nonparametric modeling. Multi-unit activity was recorded from rats doing an working memory task in control sessions and under the influence of exogenously administered tetrahydrocannabinol (THC), the primary CB found in marijuana. It was found that THC left firing rate unaltered and only slightly reduced theta oscillations. Multivariate autoregressive models, estimated from spontaneous spiking activity, were then used to describe the dynamical transformation from CA3 to CA1. They revealed that THC served to functionally isolate CA1 from CA3 by reducing feedforward excitation and theta information flow. The functional isolation was compensated by increased feedback excitation within CA1, thus leading to unaltered firing rates. Finally, both of these effects were shown to be correlated with memory impairments in the working memory task. By elucidating the circuit mechanisms of CBs, these results help close the gap in knowledge between the cellular and behavioral effects of CBs.
Si/SiGe QuBus for single electron information-processing devices with memory and micron-scale connectivity function
<p>Dataset and analysis scripts for the arXiv paper: Si/SiGe QuBus for single electron information-processing devices with memory and micron-scale connectivity function (submitted for peer-review)</p>
Neuroimaging Study of Exercise and Memory Function
ClinicalTrials.gov study NCT02057354. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Functional Magnetic Resonance Imaging (fMRI) Study of Memory in Children
ClinicalTrials.gov study NCT00242905. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of the Functioning of Prospective Memory in Breast Cancer and the Influence of Sleep
ClinicalTrials.gov study NCT03420105. IPD Sharing: NO. Countries: 1. Publications: 2.
Exercise, Age-Related Memory Decline, And Hippocampal Function
ClinicalTrials.gov study NCT01329653. IPD Sharing: YES. Countries: 1. Publications: 1.
Spatial Memory Training and Cognitive Function
ClinicalTrials.gov study NCT07002996. IPD Sharing: NO. Countries: 1. Publications: 3.
Efficacy, Transfer, and Neuro-functional Basis of a Memory Training Targeting Episodic Retrieval in Older Adults.
ClinicalTrials.gov study NCT06110234. IPD Sharing: YES. Countries: 1. Publications: 0.
Impacts of Different Training Modes (Intense Versus Ordinary) on the Immune System and Memory Functions in pwMS
ClinicalTrials.gov study NCT02571335. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.