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360 results for “meningitis”
Meningitis hGWAS results (summary statistics)
<p>Summary statistics for association between genetic variation and meningitis phenotypes. Contains human genome association and interaction effects (pGWAS.tar.bz2).</p> <p>Unpack with `tar xf `. Contents are described in the README.</p>
Fig. 2 in DNA sequencing confirms meningeal worm (Parelaphostrongylus tenuis) and muscle worm (Parelaphostrongylus andersoni) in white-tailed deer (Odocoileus virginianus): Implications for moose (Alces alces) management
Fig. 2. Summary of Parelaphostrongylus spp. infection in white-tailed deer (Odocoileus virginianus) fecal samples collected in Western Manitoba. Partial CO1 and ITS-2 genetic sequence results found white-tailed deer fecal samples with Parelaphostrongylus andersoni and Parelaphostrongylus tenuis in game hunting area (GHA) 13, 18 and 27 and only P. tenuis infected fecal pellets in GHA 22. GHA 13 and 18 (blue) are areas where moose populations are a management concern whereas GHAs 22 and 27 (yellow) are areas where moose populations are not a management concern. GHAs 18 and 22 were sampled in 2020 (light colors) while GHAs 13 and 27 were sampled in 2021 (dark colors). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 1 in DNA sequencing confirms meningeal worm (Parelaphostrongylus tenuis) and muscle worm (Parelaphostrongylus andersoni) in white-tailed deer (Odocoileus virginianus): Implications for moose (Alces alces) management
Fig. 1. Average dorsal-spined larvae (DSL) prevalence in white-tailed deer (Odocoileus virginianus) fecal samples in each game hunting area (GHA) sampled in Manitoba in 2020 and 2021. For trips, early summer collection was in June, mid-summer was July–August and late summer was August–September. GHA 13 and 18 (blue) are areas where moose populations are a management concern whereas GHAs 22 and 27 (yellow) are areas where moose populations are not a management concern. GHAs 18 and 22 were sampled in 2020 (light colors) while GHAs 13 and 27 were sampled in 2021 (dark colors). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Data from: Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis
Open the record for dataset details and reuse information.
The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis
<p><b>Background</b>: Depression is associated with worse outcomes in persons living with HIV/AIDS and has a prevalence more than three times as high as in the general population. Despite this, there are few randomized studies of antidepressants in HIV-infected Africans.</p> <p><b>Methods: </b>We enrolled 460 HIV-infected Africans with cryptococcal meningitis into a randomized clinical trial of adjunctive sertraline vs placebo (2015-2017). We screened for clinical depression using the Center for Epidemiologic Studies Depression Scale (CES-D) at one and three months after meningitis diagnosis and initiation of treatment. We evaluated the relationship between sertraline and depression, as well as associations with persistent depression, at three months.</p> <p><b>Results: </b>At one- and three-months post meningitis diagnosis, 62% (108/174) and 44% (74/169) of all subjects had depression (CES>15), respectively. At three months, sertraline-treated subjects were non-significantly more likely to be depressed than placebo-treated subjects (64% vs 37%, p=0.09) but were significantly less likely to have severe depression (CES>26) (OR 0.335; 95%CI, 0.130-0.865). Of those with depression at one month, sertraline-treated subjects were less likely than placebo-treated subjects to be depressed at three months (p=0.05). Sertraline was the only factor we found significant in predicting persistent depression at three months among those who had depression at one month.</p> <p><b>Conclusions: </b>Depression is highly prevalent in HIV-infected persons who have survived cryptococcal meningitis. We found that sertraline is associated with a modest reduction in depression in those with depression at baseline and a significant reduction in severe depression.</p>
Aseptic Meningitis: Case Definition Pictorial Algorithm
<p>This post contains the Pictorial Algorithm for Aseptic Meningitis. They are included in the case definition companion guides, which contain resources and tools specific to events that have a published Brighton Collaboration case definition.</p>
Nanopore sequencing assay to detect and diagnose tuberculous meningitis via cerebrospinal fluid
<p>This study aimed to evaluate the efficiency of nanopore sequencing for the early diagnosis of tuberculous meningitis (TBM) using cerebrospinal fluid and compared it with acid-fast bacilli (AFB) smear, mycobacterial growth indicator tube (MGIT) culture, and Xpert MTB/Rifampicin (RIF). We enrolled 64 adult patients with presumptive TBM admitted to our hospital from August 2021 to August 2023. We calculated the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of AFB smear, culture, Xpert MTB/RIF, and nanopore sequencing to evaluate their diagnostic efficacy compared with a composite reference standard for TBM. Among these 64 patients, all tested negative for TBM by AFB smear. The sensitivity, specificity, PPV, and NPV were 11.11%, 100%, 100%, and 32.2% for culture, 13.33%, 100%, 100%, and 2.76% for Xpert MTB/RIF, and 77.78%, 100%, 100% and 65.52% for nanopore sequencing, respectively. The diagnostic accuracy of the nanopore sequencing test was significantly higher than that of conventional testing methods used to detect TBM.</p>
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling: single cell RNA sequencing data
<p>Meningeal single cell RNA sequencing data</p> <p>Meningeal samples were collected from both dorsal and ventral skull, avoiding inclusion of choroid plexus. Samples were digested in 2.5 mg/mL Collagenase D (Cat. #11088858001; Roche) and 12.5 μL of 0.5 mg/mL DNAseI (Cat. #L5002139; Worthington), put on a shaker at 370C for 30 m, diluted with cold HBSS + 0.1% BSA, and mashed through a 70 μm cell strainer prior to sorting.</p> <p>Data represent live, nucleated, singlet cells (DAPI-DRAQ5+) sorted on a BD FACS Aria Fusion into HBSS + 10% FBS prior to droplet encapsulation using 10x Genomics’ Drop-seq platform (Chromium v2).</p> <p>10X chip lane is indicate by 'group' column</p> <p>Group 1 = 4 pooled homecage control (unstressed) mice</p> <p>Group 2 = 4 pooled homecage control (unstressed) mice</p> <p>Group 3 = 4 pooled mice exposed to chronic social defeat for 14 days; tissue was collected 2 hours following final defeat</p> <p>See the following repositories for data processing:</p> <p><a href="https://github.com/maryellenlynall/2019_bcell_stress/blob/master/bcellstress20.Rmd">https://github.com/maryellenlynall/2019_bcell_stress/</a> (processing from raw files starts at bcellstress020.Rmd)</p> <p><a href="https://github.com/staceykigar/meningeal_neut/">https://github.com/staceykigar/meningeal_neut/</a></p> <p>We also provide a processed dataset (processed.RData) with assays 'counts' and 'logcounts' which is the processed single cell object saved at line "# Save object for upload to Zenodo" in script <a href="https://github.com/staceykigar/meningeal_neut/">https://github.com/staceykigar/meningeal_neut/</a>neutrophilstress01.Rmd </p> <p>Cluster annotations are in sce$Annotation</p> <p>Neutrophil subcluster annotations are in sce$Subcluster</p> <p>Sample condition is in sce$cond, where "HC" indicates homecage control and "SD" indicates chronic social defeat</p> <p>10X chip lane is in sce$group</p>
Aseptic Meningitis: Background rates literature review and visualization
<p>Literature review of background rates for aseptic meningitis and visualization in forest plots.</p>
Safety and Immunogenicity of Different Meningitis Vaccine Formulations in Adolescents and Young Adults
ClinicalTrials.gov study NCT01272180. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Middle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL® n-BCA
ClinicalTrials.gov study NCT04816591. IPD Sharing: YES. Countries: 2. Publications: 1.
Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis
ClinicalTrials.gov study NCT01540838. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
A Surveillance Study of Diseases Specified as Adverse Events of Special Interest, of Other Adverse Events Leading to Hospitalisation or Death, and of Meningitis in Children in Africa Prior to Implemen
ClinicalTrials.gov study NCT02374450. IPD Sharing: NO. Countries: 3. Publications: 1.
Embolization of the Middle Meningeal Artery for the Prevention of Chronic Subdural Hematoma Recurrence in High Risk Patients (EMPROTECT)
ClinicalTrials.gov study NCT04372147. IPD Sharing: YES. Countries: 1. Publications: 2.
Safety of and Immune Response to a Meningitis Vaccine in HIV-Infected Children and Youth
ClinicalTrials.gov study NCT00459316. IPD Sharing: Not stated. Countries: 2. Publications: 10.
Optimizing the Dose of Flucytosine for the Treatment of Cryptococcal Meningitis
ClinicalTrials.gov study NCT06414512. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The SQUID Trial for the Embolization of the Middle Meningeal Artery for Treatment of Chronic Subdural Hematoma (STEM)
ClinicalTrials.gov study NCT04410146. IPD Sharing: NO. Countries: 4. Publications: 1.
High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals
ClinicalTrials.gov study NCT00885703. IPD Sharing: Not stated. Countries: 8. Publications: 4.
Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis
ClinicalTrials.gov study NCT00145249. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis
ClinicalTrials.gov study NCT01802385. IPD Sharing: YES. Countries: 1. Publications: 13.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.