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83 results for “mental stress”
Normalized and batch-corrected concentration of 43 immune markers from 248 subjects with stress-related mental disorders and 36 healthy controls
<h1>Abstract</h1> <p>In a subset of patients with mental disorders, such as depression, low-grade inflammation and altered immune marker concentrations are observed. However, these immune alterations are often assessed by only one data type and small markers panels. Here, we used a transdiagnostic approach and combined data from two cohorts to define subgroups of depression symptoms across the diagnostic spectrum through a large-scale multi-omics clustering approach in 237 individuals. The method incorporated age, body mass index (BMI), 43 plasma immune markers and RNA-seq data from peripheral mononuclear blood cells (PBMCs). Our initial clustering revealed four clusters, including two immune-related depression symptom clusters characterized by elevated BMI, higher depression severity and elevated levels of immune markers such as interleukin-1 receptor antagonist (IL-1RA), C-reactive protein (CRP) and C-C motif chemokine 2 (CCL2 or MCP-1). In contrast, the RNA-seq data mostly differentiated a cluster with low depression severity, enriched in brain related gene sets. This cluster was also distinguished by electrocardiography data, while structural imaging data revealed differences in ventricle volumes across the clusters. Incorporating predicted cell type proportions into the clustering resulted in three clusters, with one showing elevated immune marker concentrations. The cell type proportion and genes related to cell types were most pronounced in an intermediate depression symptoms cluster, suggesting that RNA-seq and immune markers measure different aspects of immune dysregulation. Lastly, we found a dysregulation of the SERPINF1/VEGF-A pathway that was specific to dendritic cells by integrating immune marker and RNA-seq data. This shows the advantages of combining different data modalities and highlights possible markers for further stratification research of depression symptoms.</p> <h1>Methods</h1> <p>The normalized and batch-corrected concentration of 43 immune markers from 237 subjects with stress-related mental disorders and 36 healthy controls was determined in plasma. This data was used in the initial analysis. Additionally, the same measurements are provided for 11 subjects with stress-related mental disorders used in a replication analysis.</p> <p>- blood was collected in the morning under fasted conditions and plasma stored at -80°C until further processing<br>- samples were randomized into 96 well plates<br>- immune marker concentration was measured with the Meso Scale Diagnostics V-PLEX Human Biomarker 54-Plex Kit and the MESO QuickPlex SQ 120 imager according to the manufacturer's instructions<br>- additionally, high-sensitivity C-reactive protein (Tecan Group Ltd.), cortisol (Tecan Group Ltd.), interleukin (IL)-6 (Thermo Fisher Scientific), IL-6 soluble receptor (Thermo Fisher Scientific) and IL-13 (Thermo Fisher Scientific) was measured via ELISA according to the manufacturer's instructions<br>- values below the detection limit in markers measured with ELISA were set to zero and values above the detection limit to the upper limit<br>- the data was quantile-normalized (values were ranked and mapped to the quantiles of a standard normal distribution)<br>- the normalized concentration was corrected for the biobank storage position (batch_variable) via a linear model and the residuals reported as the concentration</p> <p>The following markers were measured:<br>fibroblast growth factor 2 (FGF2 or bFGF), cortisol, C-C motif chemokine 11 (CCL11 or eotaxin), CCL26 (eotaxin-3), vascular endothelial growth factor receptor 1 (VEGFR1 or Flt-1), hsCRP, intercellular adhesion molecule (ICAM)-1, interferon (IFN)-gamma, IL-1alpha, IL-1 receptor antagonist (IL-1RA), IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17B, IL-2, IL-27, IL-31, IL-5, IL-6 high sensitivity (IL-6HS), IL-7, IL-8HS, C-X-C motif chemokine 10 (CXCL10 or IP-10), CCL2 (MCP-1), CCL13 (MCP-4), CCL22 (MDC), CCL3 (MIP-1alpha), CCL4 (MIP-1beta), placental growth factor (PlGF), serum amyloid A (SAA), sIL-6R, CCL17 (TARC), angiopoietin-1 receptor (Tie-2), tumor necrosis factor (TNF or TNF-alpha), lymphotoxin-alpha (LT-alpha or TNF-beta), thymic stromal lymphopoietin (TSLP), vascular cell adhesion protein 1 (VCAM-1), vascular endothelial growth factor (VEGF)-A-HS, VEGF-C, VEGF-D</p> <p>The data is provided as a tab separated file.</p>
Data set - Stress, Mental Health and Sociocultural Adjustment in Third Culture Kids: The Mediating Roles of Resilience and Family Functioning
<p>this data set contains data derived from a cross-sectional study which explores the contributions of proximal and contextual factors in the adjustment process of a sample of internationally mobile children and adolescents having relocated to Switzerland. </p> <p>scales include child perceived stress (PSS-C; White, 2014), acculturative stress (ASIC; Suarez-Morales et al., 2007), resilience (CYRM-12; Liebenberg et al., 2013), mental health difficulties SDQ (R. Goodman, 1997), socio cultural adjustmen (SCAS-Child; Ward & Kennedy, 1999) and family functioning (McMaster Family Assessment Device (Epstein et al., 1983)). </p> <p>child age, arrival in Switzerland and cemographic information on country of origin are included</p>
Effect of Mental Stress on Myocardial Perfusion in Women
ClinicalTrials.gov study NCT03982901. IPD Sharing: YES. Countries: 1. Publications: 2.
Mental Stress Reduction in Defibrillator Patients
ClinicalTrials.gov study NCT00624520. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
ClinicalTrials.gov study NCT00118534. IPD Sharing: Not stated. Countries: 1. Publications: 5.
A Unified Intervention for Young Gay and Bisexual Men's Minority Stress, Mental Health, and HIV Risk
ClinicalTrials.gov study NCT02929069. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
PTSD (PostTraumatic Stress Disorder) Services for Veterans With SMI (Severe Mental Illness)
ClinicalTrials.gov study NCT01542229. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: Association of work-related stress with mental health problems in a special police force unit
Objectives. Law and order enforcement tasks may expose special force police officers to significant psychosocial risk factors. The aim of this work is to investigate the relationship between job stress and the presence of mental health symptoms while controlling for socio-demographical, occupational and personality variables in special force police officers. Method: At different time points, 292 out of 294 members of the 'VI Reparto Mobile', a special police force engaged exclusively in the enforcement of law and order, responded to our invitation to complete questionnaires for the assessment of personality traits, work-related stress (using the demand-control-support (DCS) and the effort-reward-imbalance (ERI) models), and mental health problems such as depression, anxiety and burnout. Results: Regression analyses showed that lower levels of support and reward and higher levels of effort and overcomittment were associated with higher levels of mental health symptoms. Psychological screening revealed 21 (7.3%) likely cases of mild depression (BDI ≥10). Officers who had experienced a discrepancy between work effort and rewards showed a marked increase in the risk of depression (OR 7.89 95%CI 2.32-26.82) when compared with their counterparts who did not perceive themselves to be in a condition of distress. Conclusions: The findings of this study suggest that self-reported work-related stress may play a role in the development of mental health problems in police officers. The prevalence of mental health symptoms in the cohort investigated here was low, but not negligible in the case of depression. Since special forces police officers have to perform sensitive tasks for which a healthy psychological functioning is needed, the results of this study suggest that steps should be taken to prevent distress and improve the mental well-being of these workers.
Delving into the Impact of Stress on Mental Health: A Data-Driven Approach
<p>This comprehensive dataset delves into the intricate relationship between stress and mental health, providing valuable insights for researchers, healthcare professionals, and individuals alike. The dataset encompasses a diverse range of variables, including self-reported stress levels, standardized mental health assessments, demographic information, and lifestyle factors. This rich data empowers researchers to conduct in-depth analyses and uncover the multifaceted connections between stress and mental Health.</p>
The Future of Stress Research: A Zenodo Collection of Datasets and Tools for Investigating the Stress-Mental Health Relationship
<p>This Zenodo collection offers a comprehensive dataset for researchers exploring the intricate relationship between stress and Mental Health. It provides a valuable resource for investigating how individual experiences influence mental well-being.</p><p><strong>Data Included:</strong></p><ul><li><strong>Participant Information:</strong> Name, age, gender, community (rural/urban), and occupation.</li><li><strong>Stress Level:</strong> Self-reported stress levels, identified stressors, and coping mechanisms.</li><li><strong>Mental Health Scores:</strong> Scores on standardized anxiety and depression scales.</li><li><strong>Mental Health State:</strong> Categorical diagnosis (Average, Poor, Excellent etc.. ).</li></ul><p> </p>
UNIVERSE: UNobtrusIVE measuRement of mental workload and stress in uncontrolled environments
<p><strong>A Dataset on Unobtrusive Measurement of Cognitive Load and Physiological Signals (EEG, PPG, EDA) in Uncontrolled Environments</strong></p> <p>The dataset (approximately 315 hours in total) consists of physiological signals from wearable electroencephalography (EEG), electrodermal activity (EDA), photoplethysmogram (PPG), acceleration, and temperature sensors. The recorded dataset is curated from 24 participants following an eight-hour cognitive load elicitation paradigm. The mentioned consumer-grade physiological signals are obtained from the Muse S EEG headband and Empatica E4 wristband. The data is balanced across controlled and uncontrolled environments and high vs. low mental workload levels. During the study, participants worked on mental arithmetic, Stroop, N-Back, and Sudoku tasks in the controlled environment (roughly half of the data) and realistic home-office tasks such as researching, programming, and writing emails in uncontrolled environments. Data labels were obtained using Likert scales, Affective Sliders, PANAS, and NASA-TLX questionnaires. The completely anonymized data set and its publicly available features open a vast potential to the research community working on mental workload detection using consumer-grade wearable sensors. Among others, the data is suitable for developing real-time cognitive load detection methods, research on signal processing techniques for challenging environments, developing artifact removal techniques from low-cost wearable devices' data, or developing personal mental workload assistants.<br> </p> <p>Follow the dataset descriptor publication for more details:</p> <p>Anders, C., Moontaha, S., Real, S., Arnrich, B.: Unobtrusive measurement of cognitive load and physiological signals in uncontrolled environments. Scientific Data 11(1), 1000 (2024).</p> <p><a href="https://doi.org/https://doi.org/10.1038/s41597-024-03738-7" target="_blank" rel="noopener">https://doi.org/https://doi.org/10.1038/s41597-024-03738-7</a></p>
Data for "Mental health problems of entrepreneurs during the COVID-19 health crisis: Fear, anxiety, and stress"
<p>Data for "Mental health problems of entrepreneurs during the COVID-19 health crisis: Fear, anxiety, and stress"</p>
The Impact of a Holistic Care Program for High-Risk Pregnancies on Stress and Mental Health
ClinicalTrials.gov study NCT06795633. IPD Sharing: YES. Countries: 1. Publications: 3.
Combined Effects of Prolonged Sitting and Mental Stress on the Cardiovascular System
ClinicalTrials.gov study NCT04207333. IPD Sharing: YES. Countries: 1. Publications: 0.
Study on Therapeutic Effect of Treating Mental Stress Induced Myocardial Ischemia
ClinicalTrials.gov study NCT02135250. IPD Sharing: Not stated. Countries: 1. Publications: 23.
Comparison of Two Brief Mindfulness Intervention for Stress, Anxiety and Burnout in Mental Health Professionals
ClinicalTrials.gov study NCT03296254. IPD Sharing: YES. Countries: 1. Publications: 8.
Mindfulness-based Stress Reduction for Pediatric Mental Health
ClinicalTrials.gov study NCT01307943. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mental Stress and Myocardial Ischemia After MI: Sex Differences, Mechanisms and Prognosis
ClinicalTrials.gov study NCT04123197. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effect of Emotional Freedom Technique on Mental Well-Being and Stress Level in Pregnant Women
ClinicalTrials.gov study NCT06181903. IPD Sharing: NO. Countries: 1. Publications: 1.
The Quality of Life, Perceived Stress and Coping Ways of Caregivers of Mentally Handicapped Individuals
ClinicalTrials.gov study NCT04790461. IPD Sharing: NO. Countries: 1. Publications: 4.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.