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Dataset results
544 results for “metabolic diseases”
Interstage single ventricle heart disease infants show dysregulation in multiple metabolic pathways: targeted metabolomics analysis - Data
<p>The data in this Zenodo entry corresponds to the data used to produce the results in <a href="https://www.jacc.org/doi/full/10.1016/j.jacadv.2022.100169">https://www.jacc.org/doi/full/10.1016/j.jacadv.2022.100169</a>. The zipped folder contains three files</p> <ul> <li>Metabolite Data.csv - The meatobilte measurements for all the samples</li> <li>Clinical Data.csv - Values for the clinical variables</li> <li>Clinical Data Descriptions.csv - More in depth explanation of clinical variables as well as possible values of the variables</li> </ul> <p><span>This study was supported by the American Heart Association (AHA</span><span>20CDA35310498 and AHA18IPA34170070) and the National Institutes </span><span>of Health (NIH/NCATS Colorado CTSA, No. UL1 TR001082 and NIH/</span><span>NHLBI K23HL12363</span></p>
Phosphoglycerate kinase is a central leverage point in Parkinson's Disease driven neuronal metabolic deficits
<p><span>Although certain drivers of familial Parkinson’s Disease (PD) compromise mitochondrial integrity, whether metabolic deficits underly other idiopathic or genetic origins of PD is unclear. Here, we demonstrate that PGK1, a gene in the PARK12 susceptibility locus, <span> </span>is rate limiting in neuronal glycolysis and that modestly increasing PGK1 expression significantly boosts <span> </span>neuronal ATP production kinetics that is sufficient to suppress PARK20-driven synaptic dysfunction. We found that his activity enhancement depends on the molecular chaperone PARK7/DJ-1, whose loss of function significantly disrupts axonal bioenergetics. <em>In-vivo, </em>viral expression of PGK1 confers protection of striatal DA axons against metabolic lesions. These data support the notion that bioenergetic deficits may underpin PD associated pathologies and point to improving neuronal ATP production kinetics as a promising path forward in PD therapeutics.</span></p>
Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER St
ClinicalTrials.gov study NCT04216589. IPD Sharing: YES. Countries: 2. Publications: 2.
Characterizing Metabolic Alterations in Early-stage chronic kidney disease (CKD) patients: A Pathway for Improved Diagnosis and Personalized Treatment.
<p>The raw NMR data that I have uploaded contains the final concentration results that have been used for this study.</p>
KidDO progress presentation 2022: Metabolic Targets for Therapeutic Intervention in Kidney Disease
<p>This is a recorded talk with head of the KidDO project - Robert Fenton - where he presents the latest project progress.</p> <p>The talk was given at one of ODIN's (the Open Discovery Innovation Network) Knowledge Sharing Events in May 2022.</p> <p> </p> <p> </p>
Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants
<p>Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressively enlarging cysts. Here we elucidate the interplay between oxidative stress, mitochondrial dysfunction, and metabolic derangement using two mouse models of PKD1 mutation, PKD1RC/null and PKD1RC/RC. Mouse kidneys with PKD1 mutation have decreased mitochondrial complexes activity. Targeted proteomics analysis shows a significant decrease in proteins involved in the TCA cycle, fatty acid oxidation (FAO), respiratory complexes, and endogenous antioxidants. Overexpressing mitochondrial-targeted catalase (mCAT) using adeno-associated virus reduces mitochondrial ROS, oxidative damage, ameliorates the progression of PKD and partially restores expression of proteins involved in FAO and the TCA cycle. In human ADPKD cells, inducing mitochondrial ROS increased ERK1/2 phosphorylation and decreased AMPK phosphorylation, whereas the converse was observed with increased scavenging of ROS in the mitochondria. Treatment with the mitochondrial protective peptide, SS31, recapitulates the beneficial effects of mCAT, supporting its potential application as a novel therapeutic for ADPKD.</p>
Obesity - Inflammation - Metabolic Disease: Effect of Lactobacillus Casei Shirota
ClinicalTrials.gov study NCT01182844. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease
ClinicalTrials.gov study NCT04727528. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease
ClinicalTrials.gov study NCT04299308. IPD Sharing: NO. Countries: 1. Publications: 2.
Alcohol Metabolism and Disease Risk in Asians
ClinicalTrials.gov study NCT04967599. IPD Sharing: YES. Countries: 1. Publications: 0.
Evaluation of TRC101 in Subjects With Chronic Kidney Disease and Metabolic Acidosis
ClinicalTrials.gov study NCT02809183. IPD Sharing: NO. Countries: 2. Publications: 1.
Intermittent Fasting and Metabolic Dysfunction Associated Fatty Liver Disease
ClinicalTrials.gov study NCT06664684. IPD Sharing: NO. Countries: 1. Publications: 6.
Coronary Imaging and Metabolic Indicators-Based Risk Prediction Model for Coronary Artery Disease(CMI-RiskCAD)
ClinicalTrials.gov study NCT07353762. IPD Sharing: NO. Countries: 1. Publications: 1.
Metabolic and Functional Consequences of Aging in Health and Disease
ClinicalTrials.gov study NCT05240885. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Noninvasive Biomarkers of Metabolic Liver Disease 1.1
ClinicalTrials.gov study NCT04828551. IPD Sharing: YES. Countries: 1. Publications: 1.
The Effect of Pramipexole on Metabolic Network Activity Compared With Levodopa in Early Parkinson's Disease
ClinicalTrials.gov study NCT01470859. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Effects Of Exenatide On Liver Biochemistry, Liver Histology And Lipid Metabolism In Patients With Fatty Liver Disease
ClinicalTrials.gov study NCT00529204. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Absorption, Metabolism, and Excretion of a Single Dose of Ferriprox® in Patients With Sickle Cell Disease
ClinicalTrials.gov study NCT01835496. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fucoidan Improves the Metabolic Profiles of Patients With Non-alcoholic Fatty Liver Disease (NAFLD)
ClinicalTrials.gov study NCT02875392. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of the Combined Application of Cynara Scolymus, Silybum Marianum, Curcuma Longa, and Glycyrrhiza Glabra in Improving Metabolic Associated Fatty Liver Disease : a Randomized Clinical Trial
ClinicalTrials.gov study NCT06798948. IPD Sharing: NO. Countries: 1. Publications: 4.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.