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179 results for “metabolic disorder”
Feeding foliar nano-selenium biofortified Panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets
<p><span>Nano-selenium (nano-Se) has been extensively explored as a biostimulant for improving the quality of grain crops. However, there are few reports about the effect on the medicinal components of Chinese herbal medicine cultured with nano-Se. Here, we sprayed nano-Se during the cultivation of </span><span><em>Panax notoginseng</em> (SePN), and measured the changes of medicinal components compared with conventional <em>Panax notoginseng</em> (PN). Furthermore, we identified a more pronounced effect of SePN on reducing obesity in animals compared with PN. By measuring antioxidant capacity, histopathology, gene expression related to glycolipid metabolism, and gut microbiota composition, we propose a potential mechanism for SePN to improve animal health.</span><span> Compared with the control groups, foliar spraying of nano-Se increased saponins content (Rb2, Rb3, Rc, F2, Rb2, and Rf) in the roots of <em>Panax notoginseng</em>, and the content of Rb2 increased by 3.9 times in particular. Interestingly, animal studies indicated that taking selenium-rich <em>Panax notoginseng</em> (SePN) can further ameliorate liver antioxidation (SOD, MDA, and GSH) and enzyme activities involved in glycolipid metabolism (ATGL and PFK). It also relieved inflammation and regulated the expression of genes (<em>MCAD</em>, <em>PPAR-α</em>, and <em>PCSK9</em>) related to fatty acid oxidation.</span> <span>The abundance ratio of Firmicutes/Bacteroides and beneficial bacteria abundance (<em>Bifidobacterium</em>, <em>Butyricimonas</em>, and <em>Parasutterella</em>) in gut microbiota were improved relative to the control. In summary, the application of nano-Se on PN may</span> <span>effectively raise the content of <em>Panax notoginseng</em> saponins (PNS) and immensely lower the risk of metabolic disorders of glycolipids.</span></p>
EPI-743 for Metabolism or Mitochondrial Disorders
ClinicalTrials.gov study NCT01642056. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of EPA and DHA in the Inflammation and Metabolic Disorders in DMD/DMB Patients
ClinicalTrials.gov study NCT01826422. IPD Sharing: NO. Countries: 1. Publications: 5.
Metabolic Disorders and Vertigo
ClinicalTrials.gov study NCT04935970. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder
ClinicalTrials.gov study NCT00423878. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance
ClinicalTrials.gov study NCT00835120. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders
ClinicalTrials.gov study NCT01720316. IPD Sharing: NO. Countries: 1. Publications: 34.
Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine
ClinicalTrials.gov study NCT00512070. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Feeding foliar nano-selenium biofortified Panax notoginseng could reduce the occurrence of glycolipid metabolism disorder in mice caused by high-fat diets
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Metabolic Disorders in Polycystic Ovarian Syndrome
ClinicalTrials.gov study NCT00172523. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy of Pediococcus Acidilactici as add-on to Antipsychotic Drugs on Metabolic Syndrome Disturbances in First-episode Psychosis and Schizophrenia Spectrum Disorders. A Double-blind Placebo-control
ClinicalTrials.gov study NCT07371325. IPD Sharing: NO. Countries: 1. Publications: 0.
Nutritional and Metabolic Disorders in HIV Infected Children and Adolescent
ClinicalTrials.gov study NCT01771562. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Estimating Prevalence of Inherited Disorders of Sulfur Amino Acids Metabolism in Patients With Psychotic Disorders.
ClinicalTrials.gov study NCT05206292. IPD Sharing: NO. Countries: 1. Publications: 5.
Metabolic Processes in Adults and Adolescents With Autism Spectrum Disorder
ClinicalTrials.gov study NCT02733120. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Exploring Physical Exercise for the Regulation and Control of Metabolic Disorders in College Students.
ClinicalTrials.gov study NCT06555159. IPD Sharing: NO. Countries: 1. Publications: 7.
Hepatocyte Transplantation for Liver Based Metabolic Disorders
ClinicalTrials.gov study NCT01345578. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Iron Metabolism Disorders in Patients With Sepsis or Septic Shock.
ClinicalTrials.gov study NCT05217836. IPD Sharing: NO. Countries: 1. Publications: 11.
Metformin for Treatment of Psoriasis Combined With Disorders of Glucose and Lipid Metabolism
ClinicalTrials.gov study NCT03629639. IPD Sharing: YES. Countries: 0. Publications: 8.
Genetic, Metabolic, and Growth Factor Repository for Cerebrovascular Disorders
ClinicalTrials.gov study NCT02910180. IPD Sharing: YES. Countries: 1. Publications: 4.
Vitamin D Metabolism in Patients With Endocrine Disorders
ClinicalTrials.gov study NCT04844164. IPD Sharing: NO. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.