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1,932 results for “metformin”
Genome editing of LKB1 gene by CRISPR/Cas9 in lung cancer cells and evaluation of its role in metformin and cisplatin response.
<pre>LKB1 is an important upstream inhibitor of the mTOR/S6Ks pathway. Loss of LKB1 is often associated with cancer, including in A549 lung cancer cell line, boosting the transformation of pre-malignant neoplasic cells. Metformin, a natural compound derived from Galega officinalis, is mainly used as a treatment for diabetes mellitus type 2 (DM2), but recently, it has been associated to lower incidence of cancer. One of the main mechanisms is by activation of AMPK through different pathways, including LKB1 activation. Activation of AMPK inhibits the mTOR pathway, protein synthesis and thus cell growth. The combination of metformin and cisplatin, a main chemothepeutic drug for lung cancer, has shown to improve treatment of cancer cells to cisplatin and also to hinder the cisplatin associated resistance common in lung cancer. Here we aim to use the CRISPR/Cas9 technology to correct the mutation presented in A549 lung cancer cells and improve their response to metformin or to the combination between metformin and cisplatin. Besides, we will assess the mTOR signaling pathway status, as well as cell growth, proliferation, cell cycle and sensitivity to apoptosis induction by cisplatin. This project may be useful as a proof of principle that in the future therapies must consider the genomic background of cancer cells before administration of a specific anticancer drug.<br><br></pre>
In silico study for screening of natural phytochemicals and metformin as a potential inhibitor of interleukin 6 as target for covid-19
<p>Interleukin 6 is considered the corner stone at treatment of covid-19 specially the severe cases and it is the marker of severe inflammation and the gate of cytokine storm , so the future studies for this important proinflammatory cytokine storm , the first target for speed recovery from sars cov2 it is overcoming this cytokine which is immune response to virus , it is responsible about the fever and most sypmtoms of severity of covid-19 also may has role at smell and taste , so this study target this interleukin-6 by discovering natural potential inhibitors of IL-6. We do molecular docking for some natural phytochemicals like EGCG , bromelain , luteolin , vitexin and isovitexin , in adding to metformin and polyetheylene glycocl </p>
VERIFY:A Study to Compare Combination Regimen With Vildagliptin & Metformin Versus Metformin in Treatment-naïve Patients With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT01528254. IPD Sharing: YES. Countries: 34. Publications: 5.
Evaluation of comparative efficacy of Babool Vati versus Tablet Metformin in the Management of Type 2 Diabetes Mellitus (Prameha)- a randomized controlled trial protocol
Open the record for dataset details and reuse information.
Dose Finding, Safety and Efficacy of Monthly Subcutaneous Canakinumab Administration in Metformin Monotherapy Treated Type 2 Diabetic Patients
ClinicalTrials.gov study NCT00900146. IPD Sharing: Not stated. Countries: 14. Publications: 3.
Study to Compare the Efficacy and Safety of Administration of the Fix Dose Combination of Linagliptin Plus Metformin in Drug naïve Type 2 Patients
ClinicalTrials.gov study NCT01708902. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Comparison of Fasiglifam (TAK-875) to Placebo and Sitagliptin in Combination With Metformin in Participants With Type 2 Diabetes
ClinicalTrials.gov study NCT01549964. IPD Sharing: Not stated. Countries: 11. Publications: 1.
Efficacy and Safety of BI 1356 in Combination With Metformin in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT00622284. IPD Sharing: Not stated. Countries: 16. Publications: 4.
Efficacy and Safety of FIAsp in a Basal-bolus Regimen Versus Basal Insulin Therapy, Both in Combination With Metformin in Adult Subjects With Type 2 Diabetes
ClinicalTrials.gov study NCT01850615. IPD Sharing: Not stated. Countries: 6. Publications: 4.
Efficacy and Safety of Empagliflozin (BI 10773) / Linagliptin (BI 1356) Fixed Dose Combination in Treatment naïve and Metformin Treated Type 2 Diabetes Patients
ClinicalTrials.gov study NCT01422876. IPD Sharing: Not stated. Countries: 22. Publications: 3.
Antecedent Metabolic Health and Metformin Aging Study
ClinicalTrials.gov study NCT04264897. IPD Sharing: YES. Countries: 1. Publications: 1.
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes
ClinicalTrials.gov study NCT01881828. IPD Sharing: Not stated. Countries: 1. Publications: 49.
A Study to Compare the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly to Those of Sitagliptin and Pioglitazone,in Subjects With Type 2 Diabetes Treated With Metformin (DURATION -
ClinicalTrials.gov study NCT00637273. IPD Sharing: Not stated. Countries: 3. Publications: 8.
An Efficacy & Safety Study of BMS-512148 in Combination With Metformin Extended Release Tablets
ClinicalTrials.gov study NCT00643851. IPD Sharing: Not stated. Countries: 7. Publications: 2.
MEtformin and Lorcaserin for WeighT Loss in Schizophrenia
ClinicalTrials.gov study NCT02796144. IPD Sharing: NO. Countries: 1. Publications: 3.
The Effect of Liraglutide Versus Placebo When Added to Basal Insulin Analogues With or Without Metformin in Subjects With Type 2 Diabetes
ClinicalTrials.gov study NCT01617434. IPD Sharing: Not stated. Countries: 9. Publications: 2.
Lifestyle Modification and Metformin Use in the Treatment of HIV
ClinicalTrials.gov study NCT00399360. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Liraglutide or Glimepiride Added to Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes
ClinicalTrials.gov study NCT00614120. IPD Sharing: Not stated. Countries: 3. Publications: 5.
Metformin Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery
ClinicalTrials.gov study NCT01433913. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Trial of Standard Chemotherapy With Metformin (vs Placebo) in Women With Metastatic Breast Cancer
ClinicalTrials.gov study NCT01310231. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.