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250 results for “microcirculation”
The human splenic microcirculation is entirely open as shown by 3D models in virtual reality. Supplementary files
<p>These materials supplement our paper "The human splenic microcirculation is entirely open as shown by 3D models in virtual reality".</p> <p><strong>Summary</strong></p> <p>The human spleen is equipped with an organ-specific microcirculation. The initial part of the venous circulation is formed by spleen-specific large microvessels, the sinuses. Sinuses eventually fuse to form venules and veins. For more than 170 years there have been debates, whether splenic red pulp capillaries join sinuses, i.e., whether the microcirculation is closed or open - or even simultaneously closed and open. We have now solved this question by three-dimensional reconstruction of a limited number of immunostained serial sections of red and white pulp areas, which were visualized in virtual reality. Splenic capillaries have special end structures exhibiting multiple small diverging endothelial cell processes, which always keep a certain distance to the walls of sinuses. Only very few capillary ends were difficult to diagnose. Positive identification of these end structures permits to conclude that the human splenic microcirculation is entirely open. This is also true for the perifollicular capillary network and for capillaries close to red pulp venules. Follicles are supplied by a relatively dense open perifollicular capillary net, which is primarily, but not exclusively, fed by sheathed and few non- sheathed capillaries from the surrounding red pulp network.</p> <p> </p> <p><strong>Interactive models</strong></p> <p>Each <em>file_sX.zip</em> contains a 3D model, registered sequence of serial sections (the input data to generate and validate the model), and an interactive / VR viewer. After you have unzipped the file, there are multiple batch files. Any of them can be used for an interactive model display on a normal monitor, but we recommend the file <em>start_index.bat</em>. Now, if you have a virtual reality headset or a 4K monitor, there are better options:</p> <ul> <li>If you have a HTC Vive-compatible headset (i.e., the "wand" controllers, typically coming with HTC Vive, Vive Pro, Vive Pro 2, etc.), please use <em>start_vive.bat</em>.</li> <li>If you have a Valve Index headset (i.e., the "knuckles" controllers, should also work with Oculus devices), please use <em>start_index.bat</em>.</li> <li>If you have a high-resolution monitor (4K or better), please use <em>start_interactive_4k.bat</em> for a high-resolution interactive model.</li> </ul> <p>In the zip-file is also a <em>README.txt</em> file with instructions on the controls for the interactive and VR viewer. It is also available in the viewer at press of F1 button. In a nutshell: </p> <ul> <li>ASWD control the movement</li> <li>I (the "i" key) turns the sections on and off</li> <li>JK advance the sections</li> <li>CV adjust the height</li> <li>E turns the model on and off.</li> </ul> <p>The viewer executables are built for Windows. They work with Windows 10, should work with previous versions of Windows (64 bit) and also with future versions, such as Windows 11. Users of other OS, such as MacOS or Linux, can use <a href="https://www.meshlab.net/">MeshLab</a> to look at the model. Any image viewer can be used to inspect the sections in the <em>img</em> folder of the unpacked zip file. However, in this case, no VR experience and no simultaneous view of both 3D reconstruction and the sections is possible.</p> <p> </p> <p><strong>Videos</strong></p> <p>The videos with the same content are mostly supplied in three versions:</p> <ul> <li>On any modern hardware you should be able to play the H.265 videos, ending in <em>...4K_h265_10bit.mov</em>, there are in 4K resolution</li> <li>If it is not the case, but you want 4K resolution, use the H.264 version, ending in <em>...4K_h264_10bit.mov,</em> it is also in 10 bit quality</li> <li>A fallback for weaker hardware and maximal compatibility is the H.264 FullHD version. It should play anywhere. Those files end in <em>...1080p_h264.mov.</em></li> </ul> <p> </p> <p><strong>Supplementary Figures S1 and S2</strong></p> <p>The supplementary figures with their legends are available in the file <a href="https://zenodo.org/record/6599487/files/supp.pdf"><em>supp.pdf</em></a>.</p> <p> </p> <p><strong>3D models corresponding to Figs. 4a-d</strong></p> <p><a href="https://zenodo.org/record/6599487/files/file_s1.zip?download=1">Supplementary file S1</a>. 3D model of ROI 1 with open capillary ends in red</p> <p><a href="https://zenodo.org/record/6599487/files/file_s2.zip?download=1">Supplementary file S2</a>. 3D model of ROI 2 with open capillary ends in red</p> <p><a href="https://zenodo.org/record/6599487/files/file_s3.zip?download=1">Supplementary file S3</a>. 3D model of ROI 3 with open capillary ends in red</p> <p><a href="https://zenodo.org/record/6599487/files/file_s4.zip?download=1">Supplementary file S4</a>. 3D model of ROI 4 with open capillary ends in red</p> <p> </p> <p><strong>File corresponding to Fig. 7a</strong></p> <p><a href="https://zenodo.org/record/6599487/files/file_s5.zip?download=1">Supplementary file S5</a>. 3D model of sinus network and open capillary ends in red</p> <p> </p> <p><strong>Files corresponding to Figs. 9a,b</strong></p> <p><a href="https://zenodo.org/record/6599487/files/file_s6.zip?download=1">Supplementary file S6</a>. 3D model of ROI 2 with perifollicular capillary network in red correspondig to Fig. 9a</p> <p><a href="https://zenodo.org/record/6599487/files/file_s7.zip?download=1">Supplementary file S7</a>. 3D model of ROI 2 with perifollicular capillary network in red and open ends in yellow corresponding to Fig. 9b</p> <p> </p> <p><strong>Videos corresponding to Figs 5a-f</strong></p> <p><a href="https://zenodo.org/record/6599487/files/sinus_-_video_s1_4K_h264_10bit.mov">Supplementary video S1</a>. Two capillaries with open ends in Fig. 5a-c</p> <p><a href="https://zenodo.org/record/6599487/files/sinus_-_video_s2_4K_h264_10bit.mov">Supplementary video S2</a>. Capillary with at least two open ends in Fig. 5d-f</p> <p> </p> <p><strong>Videos corresponding to Figs 6a-d</strong></p> <p><a href="https://zenodo.org/record/6599487/files/sinus_-_video_s3_1080p_h264.mov">Supplementary video S3</a>. Quality control of open ends shown in Fig. 5a-c and Fig. 6a,b</p> <p><a href="https://zenodo.org/record/6599487/files/sinus_-_video_s4_1080p_h264.mov">Supplementary video S4</a>. Quality control of open end shown in Fig 5d-f and Fig. 6c,d</p> <p> </p> <p><strong>Videos corresponding to Fig. 4d and Figs 8a-f</strong></p> <p><a href="https://zenodo.org/record/6599487/files/sinus_-_video_s5_1080p_h264.mov">Supplementary video S5</a>. Control of open capillary end shown in Fig. 8a-c</p> <p><a href="https://zenodo.org/record/6599487/files/sinus_-_video_s6_1080p_h264.mov">Supplementary video S6</a>. Control of open capillary end shown in Fig. 8d-f</p>
Influence of Daily Activities on Retinal Microcirculation
ClinicalTrials.gov study NCT03416088. IPD Sharing: NO. Countries: 1. Publications: 8.
LED Red Light in Modulating Choroidal Microcirculation to Retard Retinal Atrophy in Pathological Myopia
ClinicalTrials.gov study NCT07312214. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The Impact of Post Stenting Balloon Dilatation on Coronary Microcirculation in STEMI Patients Undergoing PPCI
ClinicalTrials.gov study NCT02788396. IPD Sharing: NO. Countries: 1. Publications: 1.
A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke
ClinicalTrials.gov study NCT06077305. IPD Sharing: NO. Countries: 1. Publications: 18.
Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation
ClinicalTrials.gov study NCT02191371. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Ticagrelor Versus Prasugrel on Coronary Microcirculation in Patients Undergoing Elective Percutaneous Coronary Intervention: Results of the PROtecting MICROcirculation During Coronary Angio
ClinicalTrials.gov study NCT05643586. IPD Sharing: YES. Countries: 1. Publications: 8.
Alterations of Conjunctival Microcirculation in Brain Dead Patients
ClinicalTrials.gov study NCT02483273. IPD Sharing: UNDECIDED. Countries: 1. Publications: 8.
Microcirculation and Bone Metabolism in Patients With Type 2 Diabetes Mellitus and Charcot Foot - A Pilot Study
ClinicalTrials.gov study NCT02435329. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock
ClinicalTrials.gov study NCT05357339. IPD Sharing: NO. Countries: 1. Publications: 2.
Changes in the Retinal and Carotid Microcirculation After Restoring Normoglycemia in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT03594591. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Skin Microcirculation in Patients With Lower Limb Atherosclerosis
ClinicalTrials.gov study NCT07312383. IPD Sharing: YES. Countries: 1. Publications: 4.
Effect of Kangaroo Position on Electromyographic Activity, Macrocirculation and Microcirculation of Preterm Newborns
ClinicalTrials.gov study NCT03611088. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Hyperbaric Oxygen Therapy on Microcirculation
ClinicalTrials.gov study NCT03980210. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients
ClinicalTrials.gov study NCT01271153. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Doppler Ultrasound Investigation of Microcirculations
ClinicalTrials.gov study NCT01045005. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers
ClinicalTrials.gov study NCT00152724. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Assessment of Microcirculation Alteration With Both Sublingual Microcirculation and Near-infrared Spectroscopy on ARDS
ClinicalTrials.gov study NCT05180409. IPD Sharing: NO. Countries: 1. Publications: 55.
Sublingual Microcirculation and Postoperative Ileus
ClinicalTrials.gov study NCT01828047. IPD Sharing: Not stated. Countries: 1. Publications: 17.
Evaluation of Nail Fold Microcirculation in CKD
ClinicalTrials.gov study NCT03682952. IPD Sharing: NO. Countries: 1. Publications: 7.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.