Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
18
datasets available to search
ShareScore release 0.7.1
Dataset results
18 results for “microgels”
Mechanically Resistant Poly(N-vinylcaprolactam) Microgels with Sacrificial Supramolecular Catechin Hydrogen Bonds
<p>Original data corresponding to the plots of Figures 2, 4, 5 of the manuscript and S1-S16 of the Supporting Information in *.csv format and raw data for NMR measurements.</p>
Measuring the counterion cloud of soft microgels using SANS with contrast variation
<p>The behavior of microgels and other soft and compressible colloidal particles depends on particle concentration in ways that are absent in their hard-particulate counterparts. For instance, poly-N-isopropylacrylamide (pNIPAM) microgels can spontanously deswell and reduce suspension polydispersity at high concentrations. Despite the pNIPAM network in these microgels is uncharged, the key to understand this distinct behavior relies on the existence of peripheric charged groups, which provide stability when deswollen, and the associated counterion cloud. When in close proximity, clouds of different particles overlap, effectively freeing the associated counterions, which are then able to exert an osmotic pressure that can potentially cause the microgels to change size. Up to to now, however, no direct measurement of such an ionic cloud exists, perhaps even for hard colloids, where it is referred to as electric double layer. Here, we use small-angle neutron scattering with contrast variation with different ions to isolate the change in the form factor directly related to the counterion cloud and obtain its radius and width. Our results highlight that modeling of microgel suspensions must unavoidably and explicitly consider the presence of this cloud, which is present for nearly all microgel particles synthesized today.</p>
Photoinduced Mechanical Cloaking of Diarylethene-Crosslinked Microgels
<p>Original data of the manuscript and supporting information sorted after Figures and respective panels.</p>
Survival-associated cellular response maintained in pancreatic ductal adenocarcinoma (PDAC) switched between soft and stiff 3D microgel culture
<div> <div> <div> <div> <p>Pancreatic ductal adenocarcinoma (PDAC) accounts for about 90% of all pancreatic cancer cases. Five-year survival rates have remained below 12% since the 1970s, in part due to the difficulty in detection before metastasis (migration and invasion into neighboring organs and glands). Mechanical memory is a concept that has emerged over the past decade that may provide a path towards understanding how invading PDAC cells "remember" the mechanical properties of their diseased ("stiff," elastic modulus, E ≈ 10 kPa) microenvironment even whilst invading a healthy ("soft," E ≈ 1 kPa) microenvironment. Here, we investigated the role of mechanical priming by culturing a dilute suspension of PDAC (FG) cells within a 3D, rheologically tunable microgel platform from hydrogels with tunable mechanical properties. We conducted a suite of acute (short-term) priming studies where we cultured PDAC cells in either a soft (E ≈ 1 kPa) or stiff (E ≈ 10 kPa) environment for 6 h, then removed and placed them into a new soft or stiff 3D environment for another 18 h. Following these steps, we conducted RNA-seq analyses to quantify gene expression. Initial priming in 3D culture showed persistent gene expression for the duration of the study, regardless of the subsequent environments (stiff or soft). Stiff 3D culture was associated with the down-regulation of tumor suppressors (LATS1, BCAR3, CDKN2C ), as well as the up-regulation of cancer-associated genes (RAC3). Immunofluorescence staining (BCAR3, RAC3) further supported the persistence of this cellular response, with BCAR3 upregulated in soft culture, and RAC3 upregulated in stiff-primed culture. Stiff-primed genes were stratified against patient data found in The Cancer Genome Atlas (TCGA). Upregulated genes in stiff-primed 3D culture were associated with decreased survival in patient data, suggesting a link between patient survival and mechanical priming.</p> </div> </div> </div> </div>
Probing temperature-responsivity of microgels and its interplay with a solid surface by superresolution microscopy and numerical simulations
<p>This dataset supports the publication ' Probing temperature-responsivity of microgels and its interplay with a solid surface by super resolution microscopy and numerical simulations' published on ACS Nano. DOI: https://doi.org/10.1021/acsnano.2c07569</p>
Survival-associated cellular response maintained in pancreatic ductal adenocarcinoma (PDAC) switched between soft and stiff 3D microgel culture
Open the record for dataset details and reuse information.
Research data supporting "Tunable microgel-templated porogel (MTP) bioink for 3D bioprinting applications"
<p>Raw research data supporting Ouyang L. et al., 2022, Advanced Healthcare Materials</p> <p><a href="https://doi.org/10.1002/adhm.202200027">https://doi.org/10.1002/adhm.202200027</a></p>
Revisiting the Density Profile of the Fuzzy Sphere Model for Microgel Colloids v2
<p>This Zenodo repository contains data supporting the paper “Revisiting the density profile of the fuzzy sphere model for microgel colloids”, Frank Scheffold, Soft Matter 2024, DOI: 10.1039/d4sm01045k </p>
Water slowing down drives the occurrence of the low temperature dynamical transition in microgels
<p>Data presented in the article entitled <strong>Water slowing down drives the occurrence of the low temperature dynamical transition in microgels</strong>.</p>
FasL microgels induce immune acceptance of islet allografts in nonhuman primates
<p>Islet transplantation to treat insulin-dependent diabetes is greatly limited by the need for maintenance immunosuppression. We report a strategy through which cotransplantation of allogeneic islets and streptavidin (SA)–FasL–presenting microgels to the omentum under transient rapamycin monotherapy resulted in robust glycemic control, sustained C-peptide levels, and graft survival in diabetic nonhuman primates for >6 months. Surgical extraction of the graft resulted in prompt hyperglycemia. In contrast, animals receiving microgels without SA-FasL under the same rapamycin regimen rejected islet grafts acutely. Graft survival was associated with increased number of FoxP3 + cells in the graft site with no significant changes in T cell systemic frequencies or responses to donor and third-party antigens, indicating localized tolerance. Recipients of SA-FasL microgels exhibited normal liver and kidney metabolic function, demonstrating safety. This localized immunomodulatory strategy succeeded with unmodified islets and does not require long-term immunosuppression, showing translational potential in β cell replacement for treating type 1 diabetes.</p>
Glycemic and Appetite Effects of a Pre-meal Whey-Protein Microgel
ClinicalTrials.gov study NCT06593769. IPD Sharing: NO. Countries: 1. Publications: 1.
FasL microgels induce immune acceptance of islet allografts in nonhuman primates
Open the record for dataset details and reuse information.
Manual Droplet Test, PEG Microgels
Open the record for dataset details and reuse information.
Manual shear test, PEG Microgels
Open the record for dataset details and reuse information.
High throughput gene expression profiling of yeast colonies with microgel-culture Drop-seq
GEO Series GSE121271. Saccharomyces cerevisiae; Candida albicans. 2 samples. Type: Expression profiling by high throughput sequencing.
A Study to Evaluate the Effects of Pre-Meal Whey Protein Microgels Administration on Post-Prandial Glycemic Response.
ClinicalTrials.gov study NCT04639726. IPD Sharing: NO. Countries: 1. Publications: 0.
Ionisation Equilibria and Swelling Behaviour of Weak Polyampholyte Core-shell Microgels - A Monte Carlo Study - data
<p>This repository contains research data on the published work "Ionisation and swelling behaviour of weak polyampholyte core–shell networks – a Monte Carlo study".</p>
SANS, SAXS and Rheology Data PNIPAM-PEG microgels
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.