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Dataset results
85 results for “mineralocorticoid”
The expression of glucocorticoid and mineralocorticoid receptors in corticotroph pituitary tumors
<p>Data include the basic clinical parameters of patients with corticotroph pituitary tumors and the results of the measurements of relative expression level of NR3C1 and NR3C2 genes as well as the results of the evaluation of the expression of glucocorticoid and mineralocorticoid receptor. Gene expression was measured with qRT-PCR, protein expression was assessed with immunohistochemistry.</p>
Mineralocorticoid Receptor and Obesity Induced Cardiovascular Complications
ClinicalTrials.gov study NCT01406015. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Evaluation of Vamorolone Mineralocorticoid Receptor Antagonism in Healthy Subjects
ClinicalTrials.gov study NCT06649409. IPD Sharing: NO. Countries: 1. Publications: 1.
The Role of Mineralocorticoid Receptors in Vascular Function
ClinicalTrials.gov study NCT00759525. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Role of Mineralocorticoid Receptor in Diabetic Cardiovascular Disease
ClinicalTrials.gov study NCT00865124. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Mineralocorticoid Antagonism and Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
ClinicalTrials.gov study NCT01853553. IPD Sharing: NO. Countries: 1. Publications: 1.
Hypoglycemia and the Mineralocorticoid Receptor
ClinicalTrials.gov study NCT01394627. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Trial
ClinicalTrials.gov study NCT02169089. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Mineralocorticoid Receptor (MR) Antagonist (Eplerenone) vs Amlodipine and STRIATIN
ClinicalTrials.gov study NCT03683069. IPD Sharing: NO. Countries: 1. Publications: 17.
Data for "The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor"
<p>This deposit contains all the single-molecule trajectories reported in "The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor".</p> <p>To access the tracks, open the mat file in MATLAB. This contains a MATLAB table with the following fields:</p> <p><strong>summary_table.cell_protein{i}</strong> identifies the i<sup>th</sup> dataset i.e. cell line + protein + treatment.</p> <p><strong>summary_table.X{i}{j}</strong> is an Nx2 array of x and y coordinates (in microns) for track j in condition i. N is the number of localizations in that track.</p> <p>Time interval between localizations is 200 ms.</p> <p>Details on data acquisition and tracking parameters can be found in the associated manuscript.</p>
Aldosterone and dexamethasone activate African lungfish mineralocorticoid receptor: Increased activation after removal of the amino-terminal domain
<p><span><span><span><span><span><span><span><span><span><span><span>Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of terrestrial vertebrates. Aldosterone activation of the MR regulates internal homeostasis of water, sodium and potassium, which was critical in the conquest of land by vertebrates. We studied transcriptional activation of the slender African lungfish MR by aldosterone, other corticosteroids and progesterone and find that aldosterone, 11-deoxycorticosterone, 11-deoxycortisol and progesterone have half-maximal responses (EC50s) below 1 nM and are potential physiological mineralocorticoids. In contrast, EC50s for corticosterone and cortisol were 23 nM and 66 nM, respectively. Unexpectedly, truncated lungfish MR, consisting of the DNA-binding, hinge and steroid-binding domains, had a stronger response to corticosteroids and progesterone than full-length lungfish MR, indicating that the N-terminal domain represses steroid activation of lungfish MR, unlike human MR in which the N-terminal domain contains an activation function. BLAST searches of GenBank did not retrieve a GR ortholog, leading us to test dexamethasone and triamcinolone for activation of lungfish MR. At 10 nM, both synthetic glucocorticoids are about 4-fold stronger than 10 nM aldosterone in activating full-length lungfish MR, leading us to propose that lungfish MR also functions as a GR.</span></span></span></span></span></span></span></span></span></span></span></p>
Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical Treatment
ClinicalTrials.gov study NCT05797558. IPD Sharing: YES. Countries: 1. Publications: 11.
The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
ClinicalTrials.gov study NCT03174288. IPD Sharing: NO. Countries: 1. Publications: 58.
Natural History of Apparent Mineralocorticoid Excess Syndrome
ClinicalTrials.gov study NCT00474942. IPD Sharing: Not stated. Countries: 3. Publications: 3.
Mineralocorticoid Receptor Antagonist and Pulmonary Fibrosis in COVID-19.
ClinicalTrials.gov study NCT04912011. IPD Sharing: NO. Countries: 1. Publications: 2.
Pragmatic Trial Of Alerts for Use of Mineralocorticoid Receptor Antagonists
ClinicalTrials.gov study NCT04903717. IPD Sharing: YES. Countries: 1. Publications: 1.
Antihypertensive Pharmacological Therapy With Mineralocorticoid Receptor Antagonists in Obese Hypertensive Patients
ClinicalTrials.gov study NCT03476616. IPD Sharing: NO. Countries: 1. Publications: 18.
Bioprofiling Response to Mineralocorticoid Receptor Antagonists for the Prevention of Heart Failure
ClinicalTrials.gov study NCT02556450. IPD Sharing: Not stated. Countries: 6. Publications: 7.
Mineralocorticoid Receptor, NMDA Receptor and Cognitive Function in Depression
ClinicalTrials.gov study NCT03062150. IPD Sharing: NO. Countries: 1. Publications: 4.
Ascorbic Acid Treatment in Congenital Glucocorticoids and Mineralocorticoids Deficiency Due to NNT Mutation
ClinicalTrials.gov study NCT02838472. IPD Sharing: NO. Countries: 1. Publications: 3.
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