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38 results for “mitochondrial damage”
Dataset related to: Sirtuin 3 Deficiency Aggravates Kidney Disease in Response to High-Fat Diet through Lipotoxicity-Induced Mitochondrial Damage
<p>The files contain all the dataset included in the manuscript divided by figures.</p> <p> </p> <p>Abstract: Sirtuin 3 (SIRT3) is the primary mitochondrial deacetylase that controls the antioxidant<br>pathway and energy metabolism. We previously found that renal Sirt3 expression and activity were<br>reduced in mice with type 2 diabetic nephropathy associated with oxidative stress and mitochondrial<br>abnormalities and that a specific SIRT3 activator improved renal damage. SIRT3 is modulated by<br>diet, and to assess whether Sirt3 deficiency aggravates mitochondrial damage and accelerates kidney<br>disease in response to nutrient overloads, wild-type (WT) and Sirt3-/- mice were fed a high-fat-diet<br>(HFD) or standard diet for 8 months. Sirt3-/- mice on HFD exhibited earlier and more severe<br>albuminuria compared to WT mice, accompanied by podocyte dysfunction and glomerular capillary<br>rarefaction. Mesangial matrix expansion, tubular vacuolization and inflammation, associated with<br>enhanced lipid accumulation, were more evident in Sirt3-/- mice. After HFD, kidneys from Sirt3-/-<br>mice showed more oxidative stress than WT mice, mitochondria ultrastructural damage in tubular<br>cells, and a reduction in mitochondrial mass and energy production. Our data demonstrate that Sirt3<br>deficiency renders mice more prone to developing oxidative stress and mitochondrial abnormalities<br>in response to HFD, resulting in more severe kidney diseases, and this suggests that mitochondria<br>protection may be a method to prevent HFD-induced renal injury.</p>
Data from: ApoA-I protects pancreatic β-cells from cholesterol-induced mitochondrial damage and restores their ability to secrete insulin
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GSDMD-mediated mitochondrial dysfunction in marginal cells: A potential driver of inflammation and stria vascularis damage in CIHL
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The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage
<p>The provided Dataset contains the liquid-chromatography mass spectrometry (LC-MS) raw files (3 zipped files containing the Thermo .raw files) and one zipped file containing three tables extracted containing the peak information (Compound ID, expected RT (min), Filename, Injection Volume (uL), peak height, peak area, actual RT (min), RT Delta, formula, adduct, m/z (Expected), m/z (Apex), m/z (Delta in ppm) and S/N (signa-to-noise)) of the steady state and the 13C6 glucose-traced metabolite measurements for the above mentioned (see title) publication in Cell Reports.</p> <p>The data was measured using either anion-chromatography coupled to high resolution mass spectrometry (for anionic compounds, including intermediates from the TCA cycle, glycolysis, pentose phosphate pathway and nucleotides) or ultra high performance liquid chromatography coupled to high resolution mass spectrometry (amine-containing compounds, including amino acids and polyamines). The methods used for extracting and analyzing the samples are described in detail in the above mentioned publication. The data deposited here is shown in figure 7a and b and figure S7a, b and c.</p> <p> </p> <p> </p>
Mitochondrial dysfUnction: a Key Player in Doxorubicin-induced Skeletal and Cardiac muscLE Damage
ClinicalTrials.gov study NCT05731375. IPD Sharing: YES. Countries: 1. Publications: 0.
Relationship Between Fatigue and Mitochondrial Damage in Patients With HIV/AIDS
ClinicalTrials.gov study NCT00106795. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The effects of mitochondrial damages under stress or during aging on osteocytes networks homeostasis
GEO Series GSE235103. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial Protein Import Stress Causes Lysosomal Damage and Tissue Atrophy
GEO Series GSE282262. Saccharomyces cerevisiae; Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N(6)-Carboxymethyllysine
GEO Series GSE182719. Mus musculus. 44 samples. Type: Expression profiling by high throughput sequencing.
ROSALIND protects the mitochondrial translational machinery from oxidative damage
GEO Series GSE249588. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy
GEO Series GSE298056. Homo sapiens. 24 samples. Type: Other.
Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts
GEO Series GSE145693. Homo sapiens. 6 samples. Type: Expression profiling by array.
Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress [ChIP-seq]
GEO Series GSE221339. Homo sapiens; Mus musculus. 40 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Oocyte-specific deletion of Eif5 causes apoptosis of mouse oocytes within the early growing follicles by mitochondrial fission defect and DNA damage
GEO Series GSE263785. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae
GEO Series GSE52242. Saccharomyces cerevisiae. 6 samples. Type: Expression profiling by high throughput sequencing.
Tumor exosomes aggravate mitochondrial damage in myocardial ischemia/reperfusion injury
GEO Series GSE267761. Mus musculus. 6 samples. Type: Non-coding RNA profiling by array.
Hexokinase 2 Exacerbates Mitochondrial Damage, Neuroinflammation, and Lipid accumulation by promoting ACSL4 ISGylation in Sepsis-Associated Encephalopathy
GEO Series GSE280721. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
DNA damage-activated mitochondrial fatty acid oxidation drives senescence
GEO Series GSE272659. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype
ClinicalTrials.gov study NCT07006194. IPD Sharing: Not stated. Countries: 1. Publications: 0.
High-dose Ascorbic Acid Intravenous Injection Decreases Mitochondrial DNA Damage in Chronic Fatigue Patients: Randomized-controlled Study
ClinicalTrials.gov study NCT01926132. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.