Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
54
datasets available to search
ShareScore release 0.9.0
Dataset results
54 results for “mitochondrial derivatives”
Polygenic risk scores validated in patient-derived cells stratify for mitochondrial subtypes of Parkinson's disease
<p><strong>Background</strong> Parkinson’s disease (PD) is the fastest growing neurodegenerative disorder, with affected individuals expected to double during the next 20 years. This raises the urgent need to better understand the genetic architecture and downstream cellular alterations underlying PD pathogenesis, in order to identify more focused therapeutic targets. While only ∼10% of PD cases can be clearly attributed to monogenic causes, there is mounting evidence that additional genetic factors could play a role in idiopathic PD (iPD). In particular, common variants with low to moderate effect size in multiple genes regulating key neuroprotective activities may act as risk factors for PD. In light of the well-established involvement of mitochondrial dysfunction in PD, we hypothesized that a fraction of iPD cases may harbour a pathogenic combination of common variants in nuclear-encoded mitochondrial genes, ultimately resulting in neurodegeneration.</p> <p><strong>Methods</strong> to capture this mitochondria-related “missing heritability”, we leveraged on existing data from previous genome-wide association studies (GWAS) – i.e., the large PD GWAS from Nalls and colleagues. We then used computational approaches based on mitochondria-specific polygenic risk scores (mitoPRSs) for imputing the genotype data obtained from different iPD case-control datasets worldwide, including the Luxembourg Parkinson’s Study (412 iPD patients and 576 healthy controls) and the COURAGE-PD cohorts (7270 iPD cases and 6819 healthy controls).</p> <p><strong>Results</strong> applying this approach to gene sets controlling mitochondrial pathways potentially relevant for neurodegeneration in PD, we demonstrated that common variants in genes regulating <em>Oxidative Phosphorylation (OXPHOS</em>-PRS<em>)</em> were significantly associated with a higher PD risk both in the Luxembourg Parkinson’s Study (odds ratio, OR=1.31[1.14-1.50], <em>p</em>=5.4e-04) and in COURAGE-PD (OR=1.23[1.18-1.27], <em>p</em>=1.5e-29). Functional analyses in primary skin fibroblasts and in the corresponding induced pluripotent stem cells-derived neuronal progenitor cells from Luxembourg Parkinson’s Study iPD patients stratified according to the <em>OXPHOS</em>-PRS, revealed significant differences in mitochondrial respiration between high and low risk groups (<em>p</em> < 0.05). Finally, we also demonstrated that iPD patients with high <em>OXPHOS</em>-PRS have a significantly earlier age at disease onset compared to low-risk patients.</p> <p><strong>Conclusions</strong> our findings suggest that OXPHOS-PRS may represent a promising strategy to stratify iPD patients into pathogenic subgroups – in which the underlying neurodegeneration is due to a genetically defined mitochondrial burden – potentially eligible for future, more tailored mitochondrially targeted treatments.</p>
Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia
Open the record for dataset details and reuse information.
FIGURE 1. Maximum-likehood phylogenetic analyses derived from partial mitochondrial 16S in Worldwide revision of the genus Fraseroscyphus Boero and Bouillon, 1993 (Cnidaria: Hydrozoa): an integrative approach to establish new generic diagnoses
FIGURE 1. Maximum-likehood phylogenetic analyses derived from partial mitochondrial 16S rRNA gene sequences (479 bp). Numbers near the nodes indicate bootstrap or Bayesian posterior probability values. Values lower than 50 or 0.5 were omitted, or labelled with "<". The scale bar represents 0.05 substitutions per site. * To avoid potential problemtic sequences, the sequences of F. hozawai (KT190714) and S. tricuspidatus (KT190735) represent the most abundant haplotypes (clones) shared by different samples of each species (Table 3), without apparent insertions or deletions disrupting the secondary structure of the Region I–III of hydrozoan 16S rRNA.
Human-derived fecal microbiota transplantation alleviates mitochondrial dysfunction and social deficits in the BTBR mouse model for autism
<p><span><span>Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by social communication deficiencies and stereotypic behaviors influenced by hereditary and/or environmental risk factors. There are currently no approved medications for treating the core symptoms of ASD. Human fecal microbiota transplantation (FMT) has emerged as a potential intervention to improve autistic symptoms, but the underlying mechanisms are not fully understood. </span></span><span><span><span><span>In this study, we evaluated the effects of human-derived FMT on behavioral and multi-omics profiles of the BTBR mice, an established model for ASD. FMT effectively alleviated the social deficits in the BTBR mice and normalized their distinct plasma metabolic profile, notably reducing the elevated long-chain acylcarnitines. Integrative analysis linked these phenotypic changes to specific <em>Bacteroides</em> species and vitamin B<sub>6</sub> metabolism. Indeed, vitamin B<sub>6</sub> supplementation improved the social behaviors in BTBR mice. Collectively, these findings shed new light on the interplay between FMT and vitamin B<sub>6</sub> metabolism and revealed a potential mechanism underlying the therapeutic role of FMT in ASD.</span></span></span></span></p>
Distribution. Sulawesi and adjacent Is (Buton, Kabaena, Muna, Peleng, Lembeh, and on some of the Togian Is); thought to be extinct on Selayar I. Pigs have been widely domesticated through the Indonesian archipelago and beyond. This primarily involved the Eurasian Wild Pig (S. scrofa), but also S. celebensis, the only other species of pig successfully domesticated. Mitochondrial DNA studies of the dispersion of these domesticated forms agree on three major dispersal events, two involving S. scrofa and one S. celebensis. Evidence supports an early human-mediated translocation of S. celebensis to Flores and Timor and two later, separate human-mediated dispersals of domestic pig through islands of SE Asia into Oceania. In addition to Flores and Timor, S. celebensis is also thought to occur in its domesticated form on Halmahera, Lendu, Roti, and Savur Is, and even on Simeulue and Nias Is to the W of Sumatra and far from its island of origin, Sulawesi. In the Moluccas, and possibly elsewhere in this region, introduced S. celebensis are thought to have hybridized with other introduced pigs of S. scrofa derivation, and apparent hybrids between these species are now reported to survive on a number of islands, including Salawatti, Great Kei, Dobu, Seram, Ambon, Bacan, Ternate, Morotai, and New Guinea. It is also reported that in the 19" century the sows of domestic pigs in Sulawesi frequently mated with wild animals, after which they returned to their villages. in Suidae
Distribution. Sulawesi and adjacent Is (Buton, Kabaena, Muna, Peleng, Lembeh, and on some of the Togian Is); thought to be extinct on Selayar I. Pigs have been widely domesticated through the Indonesian archipelago and beyond. This primarily involved the Eurasian Wild Pig (S. scrofa), but also S. celebensis, the only other species of pig successfully domesticated. Mitochondrial DNA studies of the dispersion of these domesticated forms agree on three major dispersal events, two involving S. scrofa and one S. celebensis. Evidence supports an early human-mediated translocation of S. celebensis to Flores and Timor and two later, separate human-mediated dispersals of domestic pig through islands of SE Asia into Oceania. In addition to Flores and Timor, S. celebensis is also thought to occur in its domesticated form on Halmahera, Lendu, Roti, and Savur Is, and even on Simeulue and Nias Is to the W of Sumatra and far from its island of origin, Sulawesi. In the Moluccas, and possibly elsewhere in this region, introduced S. celebensis are thought to have hybridized with other introduced pigs of S. scrofa derivation, and apparent hybrids between these species are now reported to survive on a number of islands, including Salawatti, Great Kei, Dobu, Seram, Ambon, Bacan, Ternate, Morotai, and New Guinea. It is also reported that in the 19" century the sows of domestic pigs in Sulawesi frequently mated with wild animals, after which they returned to their villages.
FIGURE 1. Neighbor-joining tree derived from mitochondrial cytochrome oxidase 1 in Identification of early life-history stages of Caribbean Apogon (Perciformes: Apogonidae) through DNA Barcoding
FIGURE 1. Neighbor-joining tree derived from mitochondrial cytochrome oxidase 1 sequences showing genetic lineages of Apogon species from Bahamas (BAH), Belize (BLZ), Curaçao (CUR), Florida (FCC, FWRI, SMS), and Saba Bank (SAB). L = larva, J = juvenile, A = adult.
Serum starvation affects mitochondrial metabolism of Adipose-derived Stem/stromal Cells
<p>Dataset of the scientific publication 'Serum starvation affects mitochondrial metabolism of Adipose-derived Stem/stromal Cells '</p>
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells
ClinicalTrials.gov study NCT06967831. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
ClinicalTrials.gov study NCT05872139. IPD Sharing: NO. Countries: 1. Publications: 0.
The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
ClinicalTrials.gov study NCT04334135. IPD Sharing: YES. Countries: 1. Publications: 1.
Study to Assess Safety and Efficacy of the Second Mitochondrial-derived Activator of Caspases (SMAC) Mimetic Debio 1143
ClinicalTrials.gov study NCT04122625. IPD Sharing: NO. Countries: 3. Publications: 0.
Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity
GEO Series GSE295742. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial-derived Oxidative Stress Alters Gene Expression and DNA Methylation in the Heart [methylation]
GEO Series GSE54895. Mus musculus. 16 samples. Type: Methylation profiling by genome tiling array.
Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration
GEO Series GSE68240. Homo sapiens. 6 samples. Type: Expression profiling by array.
Enabling phenotypic drug discovery for neurological mitochondrial DNA disorders with patient-derived neural progenitor cells
GEO Series GSE70071. Homo sapiens. 40 samples. Type: Expression profiling by array.
Mitochondrial-derived Oxidative Stress Alters Gene Expression and DNA Methylation in the Heart
GEO Series GSE54896. Mus musculus. 31 samples. Type: Expression profiling by array; Methylation profiling by genome tiling array.
Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity [scRNA-seq]
GEO Series GSE313764. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Adipose-derived mesenchymal stem cells inhibit JNK-mediated mitochondrial retrograde pathway to alleviate acetaminophen-induced acute liver injury
GEO Series GSE218879. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
HIF1α deletion promotes mitochondrial repurposing in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages
GEO Series GSE279117. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
iPSC-derived 2D and 3D models of mitochondrial disease reveal early defects in neuronal morphogenesis and identify intervention strategies
GEO Series GSE152915. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.