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20 results for “mitochondrial inheritance”
Inter-Chemical Correlation results for the study: HHEARx2017-1740 (Mitochondrial DNA biomarkers of prenatal metal mixture exposure: intergenerational inheritance and infant growth)
Title: Mitochondrial DNA biomarkers of prenatal metal mixture exposure: intergenerational inheritance and infant growth <br>Species: Homo sapiens <br>Number of samples: 1423 <br>Number of named analytes: 20 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=19 <br>
Mitochondrial epigenetics brings new perspectives on doubly uniparental inheritance in bivalves
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A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease
ClinicalTrials.gov study NCT02473445. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Data from: Sexual reproduction in Aspergillus flavus sclerotia: acquisition of novel alleles from soil populations and uniparental mitochondrial inheritance
Aspergillus flavus colonizes agricultural commodities worldwide and contaminates them with carcinogenic aflatoxins. The high genetic diversity of A. flavus populations is largely due to sexual reproduction characterized by the formation of ascospore-bearing ascocarps embedded within sclerotia. A. flavus is heterothallic and laboratory crosses between strains of the opposite mating type produce progeny showing genetic recombination. Sclerotia formed in crops are dispersed onto the soil surface at harvest and are predominantly produced by single strains of one mating type. Less commonly, sclerotia may be fertilized during co-infection of crops with sexually compatible strains. In this study, laboratory and field experiments were performed to examine sexual reproduction in single-strain and fertilized sclerotia following exposure of sclerotia to natural fungal populations in soil. Female and male roles and mitochondrial inheritance in A. flavus were also examined through reciprocal crosses between sclerotia and conidia. Single-strain sclerotia produced ascospores on soil and progeny showed biparental inheritance that included novel alleles originating from fertilization by native soil strains. Sclerotia fertilized in the laboratory and applied to soil before ascocarp formation also produced ascospores with evidence of recombination in progeny, but only known parental alleles were detected. In reciprocal crosses, sclerotia and conidia from both strains functioned as female and male, respectively, indicating A. flavus is hermaphroditic, although the degree of fertility depended upon the parental sources of sclerotia and conidia. All progeny showed maternal inheritance of mitochondria from the sclerotia. Compared to A. flavus populations in crops, soil populations would provide a higher likelihood of exposure of sclerotia to sexually compatible strains and a more diverse source of genetic material for outcrossing.
Frequent paternal mitochondrial inheritance and rapid haplotype frequency shifts in copepod hybrids
<p>Mitochondria are assumed to be maternally inherited in most animal species, and this foundational concept has fostered advances in phylogenetics, conservation, and population genetics. Like other animals, mitochondria were thought to be solely maternally inherited in the marine copepod <i>Tigriopus californicus, </i>which has served as a useful model for studying mitonuclear interactions, hybrid breakdown, and environmental tolerance. However, we present PCR, Sanger sequencing, and Illumina Nextera sequencing evidence that extensive paternal mitochondrial DNA (mtDNA) transmission is occurring in inter-population hybrids of <i>T. californicus</i>. PCR on four types of crosses between three populations (total sample size of 376 F1 individuals) with 20% genome-wide mitochondrial divergence showed 2% to 59% of F1 hybrids with both paternal and maternal mtDNA, where low and high paternal leakage values were found in different cross directions of the same population pairs. Sequencing methods further verified nucleotide similarities between F1 mtDNA and paternal mtDNA sequences. Interestingly, the paternal mtDNA in F1s from some crosses inherited haplotypes that were uncommon in the paternal population. Compared to some previous research on paternal leakage, we employed more rigorous methods to rule out contamination and false detection of paternal mtDNA due to non-functional nuclear mitochondrial DNA fragments. Our results raise the potential that other animal systems thought to only inherit maternal mitochondria may also have paternal leakage, which would then affect the interpretation of past and future population genetics or phylogenetic studies that rely on mitochondria as uniparental markers.</p>
A Safety Study for Previously Treated Vatiquinone (PTC743) Participants With Inherited Mitochondrial Disease
ClinicalTrials.gov study NCT05218655. IPD Sharing: Not stated. Countries: 7. Publications: 0.
Data from: Selective sweeps of mitochondrial DNA can drive the evolution of uniparental inheritance
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Data from: Early replication dynamics of sex-linked mitochondrial DNAs in the doubly uniparental inheritance species Ruditapes philippinarum (Bivalvia Veneridae)
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Data from: Sexual reproduction in Aspergillus flavus sclerotia: acquisition of novel alleles from soil populations and uniparental mitochondrial inheritance
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Frequent paternal mitochondrial inheritance and rapid haplotype frequency shifts in copepod hybrids
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Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs
GEO Series GSE239815. Homo sapiens; Mus musculus. 307 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea
GEO Series GSE266324. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
A maternally inherited polymorphism in mitochondrial genome alters immune cell metabolism and protects mice from skin inflammation
GEO Series GSE126956. Mus musculus. 8 samples. Type: Expression profiling by array.
A PGC-1alpha-dependent decrease in mitochondrial oxidative metabolism in muscle of humans with inherited insulin resistance
GEO Series GSE36297. Homo sapiens. 16 samples. Type: Expression profiling by array.
Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders
GEO Series GSE294049. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Transgenerational inheritance of increased mtDNA triggers mitochondrial UPR and modulates aging [WT vs. TGQ]
GEO Series GSE157031. Caenorhabditis elegans. 6 samples. Type: Expression profiling by high throughput sequencing.
Human polar body transfer eliminates the transmission of inherited mitochondrial DNA variants [mRNA]
GEO Series GSE86570. Homo sapiens. 45 samples. Type: Expression profiling by array.
Human polar body transfer eliminates the transmission of inherited mitochondrial DNA variants [methylation]
GEO Series GSE86648. Homo sapiens. 39 samples. Type: Methylation profiling by genome tiling array.
Transgenerational inheritance of mitochondrial stress adaptation in C. elegans
GEO Series GSE85835. Caenorhabditis elegans. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Human polar body transfer eliminates the transmission of inherited mitochondrial DNA variants
GEO Series GSE86650. Homo sapiens. 84 samples. Type: Expression profiling by array; Methylation profiling by genome tiling array.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.