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142 results for “mitochondrial stress”

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zenodo44/100

Metabolomics data associated with "Glial swip-10 controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis"

Raw feature tables used for metabolomic analysis of the Caenorhabditis elegans mutant swip-10. The data were generated using liquid chromatography coupled high-resolution mass spectrometry. Two different columns were used: HILIC (+ ESI) and C18 (-ESI), coupled to a Thermo Q-Exactive Orbitrap mass spectrometer. The feature tables were generated using open-source peak peaking and alignment R packages: apLCMS and xMAanalyzer. See more details in the associated manuscript.

opencc-by-4.0Aug 2024View details →

zenodo40/100

mRNA expression data of genes related to mitochondrial quality control in hepatopancreas of the two marine bivalves, Mytilus edulis and Crassostrea gigas, during short-term hypoxia/reoxygenation stress

Coastal environments commonly experience strong oxygen fluctuations. Resulting hypoxia/reoxygenation stress can negatively affect mitochondrial functions, since oxygen deficiency impairs ATP generation, whereas a surge of oxygen causes mitochondrial damage by oxidative stress mechanisms. Marine intertidal bivalves are adapted to fluctuating oxygen conditions, yet the underlying molecular mechanisms that sustain mitochondrial integrity and function during oxygen fluctuations are not yet well understood. We used targeted mRNA expression analysis to determine the potential involvement of the mitochondrial quality control mechanisms in responses to short-term hypoxia (24 h at <0.01% O2) and subsequent reoxygenation (1.5 h at 21% O2) in two hypoxia-tolerant marine bivalves, the Pacific oysters Crassostrea gigas and the blue mussels Mytilus edulis. To test these hypotheses, We focused on the transcript levels of the following marker genes: for mitochondrial fission and fusion - mfn2 (encoding mitofusin 2),  opa1 (mitochondrial dynamin-like 120kDa protein), dnm1l (dynamin-1-like protein), mff  (mitochondrial fission factor), fis1 (mitochondrial fission protein 1); for protein and DNA quality control - tsfm (encoding mitochondrial translation elongation factor Ts), lonp1 (mitochondrial Lon protease),  spg7 (paraplegin), oma1 (mitochondrial metalloendopeptidase OMA1), clpB (mitochondrial caseinolytic matrix peptidase chaperone subunit B), atp23 (mitochondrial inner membrane protease ATP23), twnk (mitochondrial twinkle mtDNA helicase); and for mitophagy -  mieap (encoding mitochondrial eating protein), hyou1 (hypoxia upregulated protein 1), prkn (parkin), pink1 (PTEN- induced kinase 1), and pgam5 (mitochondrial serine/threonine protein phosphatase PGAM5). The revealed species-specific differences in the expression of the mitochondrial quality control pathways shed light on the potentially important mechanisms of mitochondrial protection against H/R-induced damage that might contribute to hypoxia tolerance in marine bivalves.

opencc-by-sa-4.0Nov 2020View details →

zenodo36/100

Raw data related to: Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD)

Abstract Fatty liver disease is a serious complication of childhood obesity. Calorie-restricted regimen (RCR) is one of the e ective therapy for this condition. Aim of the study was to evaluate the effect of lycopene-rich tomato sauce with oregano and basil extracts in obese children with fatty liver on RCR. 61 obese children with fatty liver were enrolled, 52 completed the study. A randomized cross over clinical trial was performed. Participants were assigned to RCR alone or with a supplement of lycopene-rich tomato juice for 60 days; subsequently, the groups were switched to the alternative regimen for the next 60 days. Reduction in BMI, HOMA-IR, cholesterol, triglycerides, liver size, and steatosis was more profound in tomato-supplemented group. Leptin decreased in both groups whereas adiponectin raised only after tomato supplementation. RCR is associated with the impaired engagement of T-cells glycolysis and proliferation, tomato-supplementation resulted in glycolytic metabolic activation of T-cells. Tomato juice ameliorates glucose and lipid metabolism in obese children, improve oxidative and inflammatory state and modulates the mitochondrial metabolism of T-cells contributing to a maintenance of a proper immune surveillance in children, impaired by RCR. The addition of tomato to RCR could be considered a protective and preventive support to obese child. Progetto giovani ricercatori [GR-2016-02363725] dal titolo: "Immune Tolerance, Metabolism and Multiple Sclerosis: Novel Molecular Tools to Monitor Disease Pathogenesis and Progression"

opencc-by-4.0Mar 2020View details →

zenodo36/100

Mitochondrial oxidant stress promotes alpha-synuclein aggregation and spreading in mice with mutated glucocerebrosidase

These are the data sets and plasmid sequences of the viral vectors used in the study "Mitochondrial oxidant stress promotes alpha-synuclein aggregation and spreading in mice with mutated glucocerebrosidase"

opencc-by-4.0Oct 2024View details →

zenodo36/100

OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy

Cardiomyopathy and heart failure are common manifestations in mitochondrial disease caused by deficiencies in the oxidative phosphorylation system of mitochondria (OXPHOS). Here, we demonstrate that the cardiac-specific loss of the assembly factor Cox10 of the cytochrome c oxidase causes mitochondrial cardiomyopathy in mice, which is associated with OXPHOS deficiency, lysosomal defects and an aberrant mitochondrial morphology. Activation of the mitochondrial peptidase Oma1 in Cox10-/- mice results in mitochondrial fragmentation and induction of the integrated stress response (ISR) along the Oma1-Dele1-Atf4 signalling axis. Ablation of Oma1 or Dele1 in Cox10-/- mice aggravates cardiomyopathy. ISR inhibition impairs the cardiac glutathione metabolism, limits the selenium-dependent accumulation of the glutathione peroxidase Gpx4 and increases lipid peroxidation in the heart, ultimately culminating in ferroptosis. Our results demonstrate a protective role of the Oma1-Dele1-mediated ISR in mitochondrial cardiomyopathy and link ferroptosis to OXPHOS deficiency and mitochondrial disease.

opencc-by-4.0Jul 2022View details →

dryad36/100

Data for: Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS

Spinal cord injury (SCI) often leads to physical limitations, chronic pain, significant life changes, and social isolation, increasing the risk of chronic psychological stress such as anxiety and depression. Despite the recognition of the negative effects of chronic stress on SCI recovery, the mechanisms linking stress and regeneration are not fully understood. In this study, we examined the impact of chronic stress on primary sensory axon regeneration in a mouse model of preconditioning lesions. Our findings showed that chronic stress caused mitochondrial damage and energy crisis within primary sensory neurons, hindering the regrowth of their central axons. The stress hormone corticosterone was identified as a critical factor in this process, impacting satellite glial cells instead of neurons by suppressing Kir4.1 expression and leading to increased neuronal hyperactivity and elevated ROS levels. These high levels of ROS altered the shape of the mitochondrial cristae and disrupted ATP production, which is essential for powering axonal regeneration. Our results highlight the importance of addressing psychological stress in SCI patients to promote sensory-motor rehabilitation.

opencc-zeroJun 2023View details →

dryad36/100

In fission yeast, 65 non-essential mitochondrial proteins related to respiration and stress become essential in low-glucose conditions

Mitochondria perform critical functions, including respiration, ATP production, small molecule metabolism, anti-oxidation, and they are involved in a number of human diseases. While the mitochondrial genome contains a small number of protein-coding genes, the vast majority of mitochondrial proteins are encoded by nuclear genes. In fission yeast, Schizosaccharomyces pombe, we screened 457 deletion (del) mutants deficient in nuclear-encoded mitochondrial proteins, searching for those that fail to form colonies in culture medium containing low glucose (0.03–0.1%; low-glucose sensitive, lgs), but that proliferate in regular 2–3% glucose medium. Sixty-five (14%) of the 457 deletion mutants displayed the lgs phenotype. Thirty-three of them are defective either in dehydrogenases, subunits of respiratory complexes, the TCA cycle, or in one of the 9 steps of the CoQ10 biosynthetic pathway. The remaining 32 lgs mutants do not seem to be directly related to respiration. Fifteen are implicated in translation, and 6 encode transporters. The remaining 11 function in anti-oxidation, amino acid synthesis, repair of DNA damage, microtubule cytoskeleton, intracellular mitochondrial distribution, or unknown functions. These 32 diverse lgs genes collectively maintain mitochondrial functions under low (1/20~1/60x normal) glucose concentrations. Interestingly, 30 of them have homologs associated with human diseases.

opencc-zeroSep 2023View details →

dryad36/100