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306 results for “mitral valve”
Multi-modal phantom experiments, mimicking flow through the mitral heart valve
<p>In this repository all experimental data obtained from a phantom study on the left heart, including a deformable mitral valve, is reported. Using invasive catheter pressure measurements, magnetic resonance imaging and ultrasound imaging, several parameters relevant to diagnosing heart valve disease were measured on the phantom. The data is reported in MS excel files (xlsx format) and the geometry of the phantom is reported in STL and STEP file format, together with an exploded view, indicating how the parts are put together.</p>
Defining the role of the miR-145 – KLF4 – αSMA axis in mitral valvular interstitial cell activation in myxomatous mitral valve prolapse using the canine model
<p>Mitral valve prolapse (MVP) is a common valvular disease, affecting 2-3% of the adult human population and is a degenerative condition. 5-10% of the afflicted will develop severe mitral regurgitation, cardiac dysfunction, congestive heart failure, and sudden cardiac death. Naturally occurring myxomatous MVP in dogs closely resembles MVP in humans structurally, and functional consequences are similar. In both species, valvular interstitial cells (VICs) in affected valves exhibit phenotype consistent with activated myofibroblasts with increased αSMA expression. Using VICs collected from normal and MVP-affected valves of dogs, we analyzed the miRNA expression profile of the cells and their associated small extracellular vesicles (sEV) using RNA sequencing to understand the role of non-coding RNAs and sEV in MVP pathogenesis. miR-145 was shown to be upregulated in both the affected VICs and sEV, and overexpression of miR-145 by mimic transfection in quiescent VIC recapitulates the activated myofibroblastic phenotype. Concurrently, KLF4 expression was suppressed by miR-145, and KLF4 overexpression resulted in a decrease in αSMA expression, and its suppression resulted in an increase in αSMA expression, thus confirming the miR-145 – KLF4 – αSMA axis. Targeting this axis may serve as potential therapy in controlling pathologic abnormalities found in MVP valves.</p>
Data from: The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease
<p>The behavior of the comprehensive circulating renin‐angiotensin system (RAS) in dogs with myxomatous mitral valve disease (MMVD) before the onset of congestive heart failure remains largely unexplored.</p> <p>Hypothesis/Objectives: The classical and alternative RAS activity and aldosterone concentrations will be significantly higher in dogs with American College of Veterinary Internal Medicine (ACVIM) stage B2 MMVD compared to normal dogs and dogs with ACVIM stage B1 MMVD.</p> <p>Animals: One hundred seventeen client‐owned dogs (normal = 60; B1 = 31; B2 = 26).</p> <p>Methods: Prospective observational study. Angiotensin peptides (AP) and aldosterone concentrations were measured using liquid chromatography and mass spectrometry. Angiotensin converting enzymes 1 and 2 (ACE, ACE2) and renin activity surrogates were calculated from AP concentrations. Equilibrium dialysis (ED) and immediate protease inhibition (PI) methods of AP quantification were compared in 14 healthy dogs.</p> <p>Results: Core RAS activity and aldosterone concentrations did not differ among the 3 groups. However, the balance between the alternative and classical RAS differed, with dogs with stage B2 MMVD having significantly higher ACE2 activity surrogate (ACE2surr) when compared to normal dogs (adjusted P = .02; ratio of medians for ACE2surr [B2:normal], 1.89; 95% confidence interval [CI]: 1.4‐2.6). The ED and PI methods of AP quantification were highly correlated (AngI, r = .9, P < .0001; AngII, r = .8, P = .001).</p> <p>Conclusions and Clinical Importance: Circulating alternative RAS activity, specifically the surrogate measure of ACE2 activity, was increased in dogs with stage B2 MMVD as compared to normal dogs. Equilibrium dialysis results are analogous to immediate protease inhibition in dogs.</p>
Study on Safety and Performance of Medtentia Mitral Valve Repair System in Surgical Repair of Mitral Regurgitation
ClinicalTrials.gov study NCT01678144. IPD Sharing: NO. Countries: 1. Publications: 2.
Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System
ClinicalTrials.gov study NCT02276547. IPD Sharing: NO. Countries: 3. Publications: 3.
PARTNER 3 Trial - Mitral Valve in Valve
ClinicalTrials.gov study NCT03193801. IPD Sharing: NO. Countries: 3. Publications: 1.
The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study
ClinicalTrials.gov study NCT03155373. IPD Sharing: NO. Countries: 1. Publications: 0.
Transcatheter Mitral Valve Replacement System (TMVR) Pilot Study and The Early Feasibility Study of the TMVR Transseptal System
ClinicalTrials.gov study NCT02322840. IPD Sharing: NO. Countries: 7. Publications: 3.
Expanded Clinical Study of the Tendyne Mitral Valve System
ClinicalTrials.gov study NCT02321514. IPD Sharing: Not stated. Countries: 10. Publications: 2.
The CLASP Study Edwards PASCAL TrAnScatheter Mitral Valve RePair System Study
ClinicalTrials.gov study NCT03170349. IPD Sharing: UNDECIDED. Countries: 7. Publications: 2.
NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation
ClinicalTrials.gov study NCT03015194. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Pleth Variability Index (PVI) as a Measure of Volume Status During Transcatheter Mitral Valve Repair
ClinicalTrials.gov study NCT03993938. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation
ClinicalTrials.gov study NCT00806988. IPD Sharing: Not stated. Countries: 3. Publications: 4.
Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation
ClinicalTrials.gov study NCT00807040. IPD Sharing: Not stated. Countries: 2. Publications: 7.
Evaluating the Benefit of Concurrent Tricuspid Valve Repair During Mitral Surgery
ClinicalTrials.gov study NCT02675244. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Pivotal Study of a Percutaneous Mitral Valve Repair System
ClinicalTrials.gov study NCT00209274. IPD Sharing: Not stated. Countries: 1. Publications: 39.
Mitral Implantation of TRAnscatheter vaLves
ClinicalTrials.gov study NCT02370511. IPD Sharing: NO. Countries: 1. Publications: 12.
Feasibility Study of a Percutaneous Mitral Valve Repair System.
ClinicalTrials.gov study NCT00209339. IPD Sharing: Not stated. Countries: 1. Publications: 23.
Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery
ClinicalTrials.gov study NCT00903370. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Data from: The classical and alternative circulating renin-angiotensin system in normal dogs and dogs with stage B1 and B2 myxomatous mitral valve disease
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