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25 results for “mitral valve prolapse”
Defining the role of the miR-145 – KLF4 – αSMA axis in mitral valvular interstitial cell activation in myxomatous mitral valve prolapse using the canine model
<p>Mitral valve prolapse (MVP) is a common valvular disease, affecting 2-3% of the adult human population and is a degenerative condition. 5-10% of the afflicted will develop severe mitral regurgitation, cardiac dysfunction, congestive heart failure, and sudden cardiac death. Naturally occurring myxomatous MVP in dogs closely resembles MVP in humans structurally, and functional consequences are similar. In both species, valvular interstitial cells (VICs) in affected valves exhibit phenotype consistent with activated myofibroblasts with increased αSMA expression. Using VICs collected from normal and MVP-affected valves of dogs, we analyzed the miRNA expression profile of the cells and their associated small extracellular vesicles (sEV) using RNA sequencing to understand the role of non-coding RNAs and sEV in MVP pathogenesis. miR-145 was shown to be upregulated in both the affected VICs and sEV, and overexpression of miR-145 by mimic transfection in quiescent VIC recapitulates the activated myofibroblastic phenotype. Concurrently, KLF4 expression was suppressed by miR-145, and KLF4 overexpression resulted in a decrease in αSMA expression, and its suppression resulted in an increase in αSMA expression, thus confirming the miR-145 – KLF4 – αSMA axis. Targeting this axis may serve as potential therapy in controlling pathologic abnormalities found in MVP valves.</p>
Defining the role of the miR-145 – KLF4 – αSMA axis in mitral valvular interstitial cell activation in myxomatous mitral valve prolapse using the canine model
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Mitral Valve Prolapse, Arrhythmias and Mitral Valve Surgery
ClinicalTrials.gov study NCT05562804. IPD Sharing: NO. Countries: 1. Publications: 3.
Myocardial Characterization of Arrhythmogenic Mitral Valve Prolapse (STAMP: STretch and Myocardial Characterization in Arrhythmogenic Mitral Valve Prolapse)
ClinicalTrials.gov study NCT02879825. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Genetic and Phenotypic Characteristics of Mitral Valve Prolapse
ClinicalTrials.gov study NCT03884426. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Mitral Annular Disjunction in Mitral Valve Prolapse Patients and Arrhythmia Risk
ClinicalTrials.gov study NCT06741709. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Genome-wide analysis of RNA binding proteins co-expression with alternative splicing events in mitral valve prolapse
GEO Series GSE229778. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse
ClinicalTrials.gov study NCT06341166. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse
ClinicalTrials.gov study NCT06738537. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring
ClinicalTrials.gov study NCT06378996. IPD Sharing: NO. Countries: 1. Publications: 0.
Prognostic Impact of the Location of Mitral Valve Prolapse on the Long-term Results of Mitral Plasty
ClinicalTrials.gov study NCT03113552. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Preoperative Myocardial Fibrosis Related to Mitral Valve Prolapse on Postoperative Left Ventricular Remodeling
ClinicalTrials.gov study NCT05284058. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mitral Valve Prolapse (MVP) - France Study
ClinicalTrials.gov study NCT00799565. IPD Sharing: Not stated. Countries: 1. Publications: 0.
V-Chordal Adjustable System for Chordal Replacement in Mitral Valve Insufficiency Due to Leaflet Prolapse
ClinicalTrials.gov study NCT01415947. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exercise Capacity Evaluation in Patients With Non-rheumatic Mitral Valve Prolapse (MVP)
ClinicalTrials.gov study NCT02499419. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve Prolapse
ClinicalTrials.gov study NCT05631730. IPD Sharing: YES. Countries: 1. Publications: 0.
Triangular Exclusion Technique in Isolated Posterior Mitral Valve Leaflet Prolapse for Mitral Valve Repair
ClinicalTrials.gov study NCT06778369. IPD Sharing: NO. Countries: 1. Publications: 0.
STretch and Myocardial Characterization in Arrythmogenic Mitral Valve Prolapse-2
ClinicalTrials.gov study NCT04852731. IPD Sharing: NO. Countries: 1. Publications: 0.
Genetic Basis of Mitral Valve Prolapse
ClinicalTrials.gov study NCT01719211. IPD Sharing: Not stated. Countries: 1. Publications: 0.
AI-Based Shape and Function Analysis of Mitral Valve Prolapse Using 3D Ultrasound
ClinicalTrials.gov study NCT07384871. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.