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8 results for “mixed dementia”
Dataset for research: "MTA and Koedam Score Contributes to Cognitive Impairment in Probable Alzheimer, Vascular and Mixed Dementia: A Memory Clinic Study in Indonesia"
<p>This is a dataset for research : "MTA and Koedam Score Contributes to Cognitive Impairment in Probable Alzheimer, Vascular and Mixed Dementia: A Memory Clinic Study in Indonesia"</p> <h1><strong><span>Abstract</span></strong></h1> <p><strong><span>Background</span></strong><span>. Medial Temporal Atrophy (MTA) and Parietal Atrophy (Koedam score) have been used in clinical practice to help the diagnosis of Alzheimer’s disease. However, the role of this brain imaging marker in early detection of other type of dementia remains elusive. The study aims to investigate the association between MTA and Koedam scores with the cognitive function in dementia patients (Alzheimer, vascular and mixed dementia).</span></p> <p><strong><span>Method</span></strong><span> <span>This was a</span> cross-sectional study using<span> data from a</span> Memory Clinic in Dr. Sardjito General Hospital Yogyakarta, Indonesia. The data was collected from January 2020 until December 2022. We collected the data regarding demographic and clinical characteristics, including head MRI data and Montreal Cognitive Assessment (MoCA) score. The cut-off points of MTA score and Koedam score were determined by using Receiver Operating Curve (ROC) and Youden Index. Multivariate analysis was performed to investigate variables which were associated with the cognitive function. </span></p> <p><strong><span>Result </span></strong><span>From 61 dementia patients, 22.95% was probable Alzheimer’s disease, 59.01% was vascular dementia, and 18.03% was mixed dementia. Correlation test showed that MTA and Koedam score were negatively associated with Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) score. A bivariate analysis supports the findings that patients with combination of MTA score ≥3 and Koedam score ≥2 was more likely to have poor cognitive function (OR= 11.33; p<0.05). Multivariate analysis showed higher MTA (≥3) and Koedam (≥2) scores were associated with poor cognitive function in dementia patients (OR= 13.54, 95% CI= 1.77-103.43, <em>p</em>=0.01 and OR= 5.52, 95% CI= 1.08-28.19, <em>p</em>=0.04)</span></p> <p><strong><span>Conclusion </span></strong><span>Higher MTA and Koedam score contribute to worse cognitive function in any type of dementia patients. </span></p> <p><strong><span>Keywords.</span></strong><span> Imaging Marker, Medial Temporal Atrophy (MTA), Koedam Score, Cognitive Function, Dementia</span></p>
The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life
ClinicalTrials.gov study NCT00814658. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Study of the Safety and Effectiveness of Galantamine Versus Placebo in the Treatment of Patients With Vascular Dementia or Mixed Dementia
ClinicalTrials.gov study NCT00261573. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Vaspect Study - An Open-Label Trial Of Donepezil in Vascular and Mixed Dementia
ClinicalTrials.gov study NCT00174382. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer's Disease, Vascular Dementia, and Mixed Vascular and Alzheimer's Dementia
ClinicalTrials.gov study NCT00229333. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Trial of Donepezil Between the Patients With Alzheimer's Disease and Mixed Dementia
ClinicalTrials.gov study NCT01023867. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Predictive Factors of Good Clinical Response to Cholinesterase Inhibitors in Alzheimer Disease and Mixed Dementia
ClinicalTrials.gov study NCT02187276. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Vascular lesions and brain atrophy in Alzheimer's, vascular and mixed dementia: an optimized 3T MRI protocol reveals distinctive radiological profiles
<p><strong>Background</strong></p> <p>Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the</p> <p>BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in</p> <p>terms of cerebrospinal fluid (CSF) tau and brain atrophy.</p> <p><strong>Methods</strong></p> <p>Seventy-six subjects received a diagnosis of Alzheimer’s (AD=32), vascular (VD=26) or mixed (MD=18) dementia according to Hachinski scale and NINCDS-ADRDA criteria. Three independent raters assessed the brain images acquired according to a high resolution 3T MRI protocol (including 3D FLAIR, T1, SWI and 2D coronal T2 sequences) with semiquantitative scales for vascular lesions (periventricular and deep white matter lesions, PVL and DWML, deep grey matter lesions, DGML, enlarged perivascular spaces, PVS, and microbleeds, MB) and brain atrophy (medial temporal atrophy, MTA, posterior atrophy, PA, global cortical atrophy-frontal, GCA-F, and Evans’ index). The inter-rater agreement was assessed with the intraclass correlation coefficient (ICC).</p> <p><strong>Results</strong></p> <p>Raters reached a good-to-excellent agreement for all scales (ICC ranging 0.78-0.96). A greater number of PVL (p<0.001), DWML (p<0.001), DGML (p=0.010) and PVS (p=0.001) was observed in VD compared to AD, while MD showed a significant greater number of PVL (p=0.001), DWML (p=0.002), DGML (p=0.018) and deep and juxtacortical MB (p=0.006 and p<0.001, respectively). No significant difference was observed in scores of cortical atrophy scales and Evans’ index among the three groups.</p> <p><strong>Conclusion</strong></p> <p>The use of a high-resolution 3T MRI protocol, including SWI, allowed a reliable and time-saving assessment of vascular lesions and atrophy using dedicated visual scales. Our findings confirm that white and grey matter lesions are the predominant abnormalities in both vascular and mixed dementia, whereas juxtacortical microbleeds predominate in mixed dementia, suggesting that cerebral amyloid angiopathy could be the main underlying pathology.</p>
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.