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57 results for “moa”
Cross-reactive CD8+ T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs)
<p><strong><span>Background: </span></strong><span>We have recently shown extensive sequence and conformational homology between tumor-associated antigens (TAAs) and antigens derived from microorganisms (MoAs). The present study aimed to assess the breadth of T-cell recognition specific to MoAs and the corresponding TAAs in healthy subjects (HS) and patients with cancer (CP).</span></p> <p><strong><span>Method: </span></strong><span>A library of >100 peptide-MHC (pMHC) combinations was used to generate DNA-barcode labelled multimers. Homologous peptides were selected from the Cancer Antigenic Peptide Database, as well as Bacteroidetes/Firmicutes-derived peptides. They were incubated with CD8+ T cells from the peripheral blood of HLA-A*02:01 healthy individuals (n=10) and cancer patients (n=16). T cell recognition was identified using tetramer-staining analysis. Cytotoxicity assay was performed using as target cells TAP-deficient T2 cells loaded with MoA or the paired TuA.</span></p> <p><strong><span>Results: </span></strong><span>A total of 66 unique pMHC recognized by CD8+ T cells across all groups were identified. Of these, 21 epitopes from microbiota were identified as novel immunological targets. Reactivity against selected TAAs was observed for both HS and CP. pMHC tetramer staining confirmed CD8+ T cell populations cross-reacting with CTA SSX2 and paired microbiota epitopes. Moreover, PBMCs activated with the MoA where shown to release IFNγ as well as to exert cytotoxic activity against cells presenting the paired TuA.</span></p> <p><strong><span>Conclusions: </span></strong><span>Several predicted microbiota-derived MoAs are recognized by T cells in HS and CP. Reactivity against TAAs was observed also in HS, primed by the homologous bacterial antigens. CD8+ T cells cross-reacting with MAGE-A1 and paired microbiota epitopes were identified in three subjects. Therefore, the microbiota can elicit an extensive repertoire of natural memory T cells to TAAs, possibly able to control tumor growth (“natural anti-cancer vaccination”). In addition, non-self MoAs can be included in preventive/therapeutic off-the-shelf cancer vaccines with more potent anti-tumor efficacy than those based on TAAs.</span></p>
Demouchy_Moa_Island_unpolarized_normalized_FTIRSpectra
<p>This excel file contain de unpolarized FTIR spectra display in Figure 8 of Demouchy et al. submitted to Tectonophysics. The spectra are normalized to the thinckness and baseline corrected. Contact me if you have question.</p>
Figures 7–10 in Regional Comparisons of the Thickness of Moa Eggshell Fragments (Aves: Dinornithiformes)
Figures 7–10. Histograms of moa eggshell thicknesses for samples of (Fig. 7) 340 fragments from the Wairau Bar archaeological site, Marlborough; (Fig. 8) 595 fragments from the Oamaru archaeological site; (Fig. 9) 147 fragments from Chatto Creek, Central Otago; and (Fig. 10) 125 fragments from the Shag River archaeological site, Otago.
Figure 2 in Regional Comparisons of the Thickness of Moa Eggshell Fragments (Aves: Dinornithiformes)
Figure 2. Regressions of mean eggshell thickness on latitude for the eight geographic samples in this study (Table 3) and for the 20 whole moa eggs for which measurements of eggshell thickness are possible (Gill, 2007). For eggshell fragments (open circles), the four North Island data-points are at bottom left and the four South Island ones at middle right. The regression lines and correlation coefficients are: y = 0.028x + 0.027, r = 0.75 (fragments; lower line); y = 0.034x–0.17, r = 0.44 (whole eggs; upper line).
Figure 1 in Regional Comparisons of the Thickness of Moa Eggshell Fragments (Aves: Dinornithiformes)
Figure 1. Locality map of New Zealand showing eight sites (four from each of North and South Islands) for which samples of moa eggshell fragments were measured in this study. Archaeological sites are marked with an asterisk (*).
Figures 3–6 in Regional Comparisons of the Thickness of Moa Eggshell Fragments (Aves: Dinornithiformes)
Figures 3–6. Histograms of moa eggshell thicknesses for samples of (Fig. 3) 612 fragments from North Cape, Northland; (Fig. 4) 1042 fragments from Tokerau Beach, Northland; (Fig. 5) 273 fragments from Puketitiri, Hawke's Bay; and (Fig. 6) 431 fragments from Castle Point, Wairarapa.
Figure 2 in Moa's Ark: Miocene Fossils Reveal the Great Antiquity of Moa (Aves: Dinornithiformes) in Zealandia
Figure 2. SEM image of a broken cross-section of "thick" Miocene fossil eggshell from the St Bathans deposits (NMNZ S.40938.9) showing the structure. The upper surface is the external layer of the shell. EZ = external zone, SZ = squamatic "spongy" zone, MZ = mammillary zone. Features consistent with moa eggshell include (a) the mammillae consisting of tabular wedges; (b) the mammillae being higher than wide; (c) the vesiculation in the MZ being weak or absent; (d) the absence of a resistant zone between the SZ and EZ; (e) the EZ being blocky (see Appendix 2).
Figure 5 in Moa's Ark: Miocene Fossils Reveal the Great Antiquity of Moa (Aves: Dinornithiformes) in Zealandia
Figure 5. Caudolateral view of proximal right tibiotarsi. Left: Holocene fossil upland moa Megalapteryx didinus NMNZ S.447.1. Right: St Bathans Miocene fossil NMNZ S.44691.
Figure 4 in Moa's Ark: Miocene Fossils Reveal the Great Antiquity of Moa (Aves: Dinornithiformes) in Zealandia
Figure 4. Distribution of thickness in a sample of 154 eggshell fragments from the Miocene St Bathans deposits (based on data in Appendix 1).
Figure 3 in Moa's Ark: Miocene Fossils Reveal the Great Antiquity of Moa (Aves: Dinornithiformes) in Zealandia
Figure 3. SEM image of a broken cross-section of the thickest piece of Miocene eggshell from the St Bathans deposits (NMNZ S.40937.2) showing the structure. The lower surface is the internal layer of the shell. EZ = external zone, SZ = squamatic "spongy" zone, MZ = mammillary zone.
Moa Foot
Ten Moa foot bones articulated. Faro laser arm. Objects reconstructed in Blender. Source: Objaverse 1.0 / Sketchfab
A nuclear genome assembly of an extinct flightless bird, the little bush moa
<p>We present a draft genome of the little bush moa (<em>Anomalopteryx didiformis</em>) - one of approximately nine species of extinct flightless birds from Aotearoa, New Zealand - using ancient DNA recovered from a fossil bone from the South Island. We recover a complete mitochondrial genome at 249.9X depth of coverage and almost 900 Mb of a male moa nuclear genome at ~4-5X coverage, with sequence contiguity sufficient to identify more than 85% of avian universal single-copy orthologs. We describe a diverse landscape of transposable elements and satellite repeats; estimate a long-term effective population size of ~240,000; identify a diverse suite of olfactory receptor genes and an opsin repertoire with sensitivity in the UV range; show that the wingless moa phenotype is likely not attributable to gene loss or pseudogenization; and identify potential function-altering coding sequence variants in moa that could be synthesized for future functional assays. This genomic resource should support further studies of avian evolution and morphological divergence.</p>
Genetic evidence for post-glacial expansion from a southern refugium in the eastern moa (Emeus crassus)
Cycles of glacial expansion and contraction throughout the Pleistocene drove increases and decreases, respectively, in the geographical range and population size of many animal species. Genetic data have revealed that during glacial maxima the distribution of many Eurasian animals was restricted to small refugial areas, from which species expanded to reoccupy parts of their former range as the climate warmed. It has been suggested that the extinct eastern moa (Emeus crassus)—a large, flightless bird from New Zealand—behaved analogously during glacial maxima, possibly surviving only in a restricted area of lowland habitat in the southern South Island of New Zealand during the Last Glacial Maximum (LGM). However, previous studies have lacked the power and geographic sampling to explicitly test this hypothesis using genetic data. Here we analyse 46 ancient mitochondrial genomes from Late Pleistocene and Holocene bones of the eastern moa from across their post-LGM distribution. Our results are consistent with a post-LGM increase in the population size and genetic diversity of eastern moa. We also demonstrate that genetic diversity was higher in eastern moa from the southern extent of their range, supporting the hypothesis that they expanded from a single glacial refugium following the LGM.
Study Evaluating Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation (OIC) in Subjects With Chronic Non-Malignant Pain
ClinicalTrials.gov study NCT00529087. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study Evaluating Long-Term Safety of MOA-728 in Participants With Opioid-Induced Constipation
ClinicalTrials.gov study NCT00804141. IPD Sharing: Not stated. Countries: 6. Publications: 1.
A nuclear genome assembly of an extinct flightless bird, the little bush moa
Open the record for dataset details and reuse information.
Genetic evidence for post-glacial expansion from a southern refugium in the eastern moa (Emeus crassus)
Open the record for dataset details and reuse information.
Distribution. Papua New Guinea (recorded only at the lower Strickland River in Western Province and Port Moresby in National Capital District) and NE coast of Australia from Cape York Peninsula to Keppel Bay, also on Moa, Possession, and Albany Is in Torres Strait (possibly also on other islands in this area) and Magnetic I and other coastal islands of Queensland. It might have a larger distribution along S coast ofNew Guinea. in Emballonuridae
Distribution. Papua New Guinea (recorded only at the lower Strickland River in Western Province and Port Moresby in National Capital District) and NE coast of Australia from Cape York Peninsula to Keppel Bay, also on Moa, Possession, and Albany Is in Torres Strait (possibly also on other islands in this area) and Magnetic I and other coastal islands of Queensland. It might have a larger distribution along S coast ofNew Guinea.
Subspecies and Distribution. H. c. ceruinus Gould, 1854 -Sulawesi and adjacent Is, Talaud, Moluccas, Kai, and Aru Is, New Guinea (including Waigeo and Yapen Is), Admiralty Is (Manus), Bismarck and Louisiade archipelagos, NE Australia (Cape York Peninsula and Moa and Albany Is), Solomon Is, and Vanuatu. H. c. labuanensisTomes, 1859-Malay Peninsula, Sumatra (includingMentawai, Enggano, and Bangka Is), Borneo, Kangean Is, and Philippines (Palawan and Mindanao Is). in Hipposideridae
Subspecies and Distribution. H. c. ceruinus Gould, 1854 -Sulawesi and adjacent Is, Talaud, Moluccas, Kai, and Aru Is, New Guinea (including Waigeo and Yapen Is), Admiralty Is (Manus), Bismarck and Louisiade archipelagos, NE Australia (Cape York Peninsula and Moa and Albany Is), Solomon Is, and Vanuatu. H. c. labuanensisTomes, 1859-Malay Peninsula, Sumatra (includingMentawai, Enggano, and Bangka Is), Borneo, Kangean Is, and Philippines (Palawan and Mindanao Is).
FIGURE 5 in Beyond Moa's Ark and Wallace's Line: extralimital distribution of new species of Austronothrus (Acari, Oribatida, Crotoniidae) and the endemicity of the New Zealand oribatid mite fauna
FIGURE 5. Proportions of New Zealand oribatid genera in relation to their phylogenetic and biogeographical distributions.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.