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231
datasets available to search
ShareScore release 0.9.0
Dataset results
231 results for “molecular features”
MelanoDB: Dataset files of clinical and molecular features of advanced melanoma patients treated with MAPK inhibitors
<p>MAPK inhibitors have significantly improved overall survival in patients with metastatic melanoma disease but their efficacy is still limited by primary or acquired resistance. Several studies have attempted to predict response to MAPK inhibitor therapy, however the lack of a consistent cohort prevents better definition of associations between treatment efficacy and clinical and/or molecular features. Here, we present MelanoDB, a collection of patients with metastatic melanoma treated with MAPK inhibitors. We formatted data from 8 different studies for a total of 417 cases to gather common clinical and molecular features. Whole or partial exome sequencing is available for 191 cases and gene expression for 132 cases. We provide a web application to explore the integrated data and its distribution among the collected studies, and we share this dataset to the scientific community according to FAIR principles</p> <p>These data are available under the licence CC-BY-SA.</p> <p>Here we provide a web application viewer of the database content: http://melanodb-ircm.montp.inserm.fr/</p> <p>You are requested to cite this repository in the case of using these data in a publication.</p>
Molecular features of luminal breast cancer defined through spatial and single-cell transcriptomics (codes and data files)
<p>This dataset includes all the relevant codes and data files associated with the paper ("Molecular features of luminal breast cancer defined through spatial and single-cell transcriptomics") in Clinical and Translational Medicine journal.</p>
Molecular and electrophysiological features of GABAergic neurons in the dentate gyrus reveal limited homology with cortical interneurons
<p>GABAergic interneurons tend to diversify into similar classes across telencephalic regions. However, it remains unclear whether the electrophysiological and molecular properties commonly used to define these classes are discriminant in the hilus of the dentate gyrus. Here, using patch-clamp combined with single cell RT-PCR, we compare the relevance of commonly used electrophysiological and molecular features for the clustering of GABAergic interneurons sampled from the mouse hilus and primary sensory cortex. While unsupervised clustering groups cortical interneurons into well-established classes, it fails to provide a convincing partition of hilar interneurons. Statistical analysis based on resampling indicates that hilar and cortical GABAergic interneurons share limited homology. While our results do not invalidate the use of classical molecular marker in the hilus, they indicate that classes of hilar interneurons defined by the expression of molecular markers do not exhibit strongly discriminating electrophysiological properties.</p>
Fig. 5 in First record of Heterorhabdus papilliger (Calanoida, Heterorhabdidae) from Korean waters based on morphological and molecular features
Fig. 5. Molecular phylogenetic analysis by the neighbor-joining method (Kimura 2-parameter model). Numbers in parentheses indicate GenBank accession number. Numbers at branch points indicate bootstrap values (1000 replicates).
Fig. 4. Heterorhabdus papilliger, Male. A in First record of Heterorhabdus papilliger (Calanoida, Heterorhabdidae) from Korean waters based on morphological and molecular features
Fig. 4. Heterorhabdus papilliger, Male. A. habitus, dorsal; B. habitus, right lateral; C. urosome, dorsal; D. urosome, ventral; E. antennule; F. leg 5 (anterior); G. exopod of left leg 5 (left one: anterior, right one: posterior).
Fig. 2. Heterorhabdus papilliger, Female. A in First record of Heterorhabdus papilliger (Calanoida, Heterorhabdidae) from Korean waters based on morphological and molecular features
Fig. 2. Heterorhabdus papilliger, Female. A. habitus, dorsal; B. habitus, right lateral; C. urosome, dorsal; D. urosome, left lateral; E. urosome, ventral; F. genital somite from different specimen, left lateral; G. genital somite from different specimen, dorsal; H. genital somite from different specimen, right lateral; I. genital somite from different specimen, dorsal; J. antennule.
Data File for Manuscript "Comprehensive Molecular Simulation on Triple Negative Breast Cancer Transcriptomics Features of mir-145 and 3' UTR of ARF6 mRNA"
<p>This is a data file for the manuscript "Comprehensive Molecular Simulation on Triple Negative Breast Cancer Transcriptomics Features of mir-145 and 3’ UTR of ARF6 mRNA". It comprises of molecular docking (AUTODOCK VINA 4) and dynamics data (NAMD and VMD).</p>
Fig. 120 in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Fig. 120. Distribution records of May gen. n. in Namibia and South Africa: M. bruno sp. n. (green squares; South Africa), M. ansie sp. n. (red circles; Namibia), M. rudy sp. n. (pink diamond; Namibia), M. norm sp. n. (blue triangles; Namibia).
Figs 87–93. May norm gen. n in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 87–93. May norm gen. n. sp. n. from Messum Crater, Namibia (87–89, 91–93) ♀ paratype [PJ 1852]; (90) holotype ♂ [PJ 1851]: (87) eye arrangement, dorsal; (88) cheliceral dentition, ventral; (89) metatarsal stopper, dorsal; (90) ♀ palpal claw, lateral; (91) Lawrence setae; (92) Claw tuft setae, showing indented tip; (93) leg I, prolateral.
Figs 100–110 in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 100–110. (100–104) Palystella sp. (100–102, 104 ♀ from Namibia, PJ 3533; 103 juvenile), (105–107) Pseudomicrommata sp. from Guinea and (108–110) Heteropoda sp. from Indonesia, Flores: (100, 105, 108) tarsus tip, dorsal; (101, 109) tarsus tip, lateral; (102, 106, 110) tarsus tip, ventral; (103) Lawrence setae; (104, 107) leg I, prolateral. Abbreviations: AP – plate of Lawrence setae; DP – dorsal plate of elongated setae; IP – plate of indented claw tuft setae; TS – transverse suture with slit sensilla.
Figs 64–69. May rudy gen. n in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 64–69. May rudy gen. n. sp. n., holotype ♂ from Copper Valley, Namibia: (64–67) left ♂ palp: (64) ventral, (65) retrolateral, (66) tegulum, ventral, (67) RTA, dorsal; (68) eye arrangement, dorsal; (69) metatarsal stopper, dorsal.Abbreviations: C – conductor; DE – dorsal extension of proximal embolus; S – "shoulder" of basal cymbium.
Figs 11–17. May bruno gen. n in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 11–17. May bruno gen. n. sp. n. from South Africa, ♀ paratypes from Witsand, South Africa (11–13) PJ 3524, (14–16) PJ 3525, (17) PJ 3526): (11, 14, 17) epigyne, ventral; (12, 15) vulva, dorsal; (13) vulva, posterior; (16) schematic course of internal duct system, dorsal. Abbreviations: FB – fusion bubbles; FD – fertilisation ducts; G – glands; GP – guiding pockets; SS – slit sensilla.
Figs 94–99. May norm gen. n in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 94–99. May norm gen. n. sp. n., paratypes from Messum Crater, Namibia (94–96) PJ 1852; (97–99) PJ 3543: habitus of preserved specimens (94, 97) dorsal; (95, 98) ventral; (96, 99) frontal.
Fig. 121 in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Fig. 121. Intrageneric and intergeneric distances and distance of May gen. n. to other genera for 850 bp of the nuclear 28SrDNA gene in 19 Sparassidae genera. All groups are significantly different.
Figs 78–86. May norm gen. n in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 78–86. May norm gen. n. sp. n. from Messum Crater, Namibia (78–80) holotype ♂ [PJ 1851]; (81–85) ♀ paratype [PJ 3534]; 86 ♀ paratype [PJ 1852]): (78, 81) epigyne, ventral (with mating plugs); (79, 82) vulva, dorsal; (84) vulva, anterior; (80, 83) schematic course of internal duct system, dorsal; (85) schematic course of internal duct system, anterior; (86) sternum, ventral. Abbreviations: FB – fusion bubbles; FD – fertilisation ducts; GE – glandular extensions; GP – guiding pockets; SS – slit sensilla.
Figs 34–45. May bruno gen. n in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 34–45. May bruno gen. n. sp. n. from Witsand, South Africa (34–36, 41–43) holotype ♂; (37–40, 44–45) ♀ paratype, PJ 3524. (34–39, 43) habitus of preserved spiders: (34, 37) dorsal; (35, 38) ventral; (36, 39, 43) frontal; (40) palp of ♀, lateral, showing rows of elongated setae; (41–42) palp of ♂: (41) ventral, (42) retrolateral; (44–45) tarsal tips, showing light-coloured indented claw tuft setae (white arrow), additional dark claw tufts with Lawrence setae (black arrow), and scopula hairs (grey arrow): (44) ventral, (45) lateral.
Figs 55–63. May ansie gen. n in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 55–63. May ansie gen. n. sp. n. from Kokerboom Forest, Namibia (55–57, 61–62) ♂ paratype; (58–60, 63) holotype ♂: (55–57, 60) habitus of preserved spider: (55) dorsal, (56) ventral, (57) frontal, (60) fronto-lateral [left chelicerae removed]; (58–59) ♂ palp: (58) ventral, (59) RTA, dorsal; (61–62) tarsal tips, showing additional claw tufts with Lawrence setae (black arrows) and dorsal setae (white arrow) penetrating the claw tuft: (61) lateral, (62) ventral; (63) gnathocoxae, frontal, showing absence of serrula.
Figs 1–10. May bruno gen. n in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 1–10. May bruno gen. n. sp. n. from Witsand, South Africa, holotype ♂: (1–4) left ♂ palp (1) ventral, (2) retrolateral, (3) distal tegulum, prolateral, (4) RTA, dorsal; (5–6) eye arrangement (5) frontal, (6) dorsal); (7) leg I, prolateral; (8) leg claw; (9) gnathocoxae and labium, ventral; (10) cheliceral dentition, ventral. Abbreviations: C – conductor; E – embolus; S – "shoulder" of basal cymbium.
Figs 111–119 in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 111–119. (111–115) Thelcticopis sp. from Hong Kong and (116–119) Olios sp. from Laos: (111, 116) tarsus tip, dorsal; (112, 117) tarsus tip, lateral; (113, 118) tarsus tip, ventral; (114) sternum, ventral, showing slit sense organs; (115, 119) leg I, prolateral. Abbreviations: IP – plate of indented claw tuft setae; TS – transverse suture with slit sensilla.
Figs 50–54. May ansie gen. n in May gen. n. (Araneae: Sparassidae): a unique lineage from southern Africa supported by morphological and molecular features
Figs 50–54. May ansie gen. n. sp. n., holotype ♂ from Kokerboom Forest, Namibia: (50–52) left ♂ palp: (50) ventral, (51) retrolateral, (52) detail of embolus, ventral; (53) chelicerae, ventral; (54) eye arrangement, dorsal. Abbreviations: C – conductor; DE – dorsal extension of proximal embolus; RE – round extension of distal embolus; S – "shoulder" of basal cymbium.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.