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108 results for “monocentric”
Deciphering the explanatory potential of blood pressure variables on post-operative length of stay through hierarchical clustering: A retrospective monocentric study
<p><em>Objective:</em> Mean arterial pressure is widely used as the variable to monitor during anesthesia. But there are many other variables proposed to define intraoperative arterial hypotension. The goal of the present study was to search arterial pressure variables linked with prolonged postoperative length of stay (pLOS).</p> <p><em>Design: </em>Retrospective cohort study of adult patients having received general for a scheduled non cardiac surgical procedure between 15<sup>th</sup> July 2017 and 31st December 2019.</p> <p><em>Methods:</em> pLOS was defined as a stay longer than the median (main outcome), adjusted for surgery type and duration. 330 arterial pressure variables were analyzed and organized through a clustering approach. An unsupervised hierarchical aggregation method for optimal cluster determination, employing Kendall's tau coefficients and a penalized Bayes information criterion was used. Variables were ranked using the absolute standardized mean distance (aSMD) to measure their effect on pLOS. Finally, after multivariate independence analysis, the number of variables was reduced to three.</p> <p><em>Results:</em> Our study examined 9,516 patients. When LOS is defined as strictly greater than the median, 34% of patients experienced pLOS. Key arterial pressure variables linked with this definition of pLOS included the difference between the highest and lowest pulse pressure values computed throughout the surgery (aSMD[95%CI] =0.39[0.31-0.40], p<0.001), the accumulated time pulse pressure above 61mmHg (aSMD = 0.21[0.17-0.25], p<0.001), and the lowest MAP during surgery (aSMD= 0.20[0.16-0.24], p<0.001).</p> <p><em>Conclusions: </em>By applying a clustering approach, three arterial pressure variables were associated with pLOS. This scalable method can be applied to various dichotomized outcomes.</p>
Monocentric retrospective cohort of 30,423 COVID-19 patients
<p><span>Population and design: </span><span>Monocentric cohort comparing COVID-19 patients exposed or not exposed to the treatment hydroxychloroquine (HCQ)+azithromycin (AZ) used as a standard of care in our center (Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France). The inclusion period was from 2 March 2020 to 31 December 2021, with a follow-up period of 6 weeks.</span></p> <p><span>Inclusion and exclusion criteria: </span><span>Data included were those of patients ≥ 18 years of age with PCR-proven COVID-19 disease regardless of symptoms (asymptomatic or symptomatic) and treated in our centre, i.e. having had a medical examination by one of the doctors in our centre (Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France) either as outpatients or as inpatients, i.e. hospitalized on the day of the visit in our outpatient unit following evaluation or directly transferred from another medical ward except intensive care unit. The reasons for exclusion were an erroneous patient identification (identity surveillance and duplicates), lack of available medical data, lack of COVID-19 after checking the medical record (including patients without COVID-19 consulting for a post-COVID-19 syndrome), expression of opposition to the use of their medical data for research purposes (in accordance with European General Data Protection Regulation), and data from patients hospitalized in our center after intensive care. Data from COVID-19 outpatients left without medical advice were excluded.</span></p>
Deciphering the explanatory potential of blood pressure variables on post-operative length of stay through hierarchical clustering: A retrospective monocentric study
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Data from: Functional monocentricity with holocentric characteristics and chromosome-specific centromeres in a stick insect
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Monocentric retrospective cohort of 30,423 COVID-19 patients
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Data from: Wisdom of the caregivers: pooling individual subjective reports to diagnose states of consciousness in brain injured patients, a monocentric prospective study
OBJECTIVES : The clinical distinction between vegetative state/unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) is a key step to elaborate a prognosis and formulate an appropriate medical plan for any patient suffering from disorders of consciousness (DoC). However, this assessment is often challenging and may require specialized expertise. In this study, we hypothesized that pooling subjective reports of the level of consciousness of a given patient across several nursing staff members can be used to clinically detect MCS. SETTING AND PARTICIPANTS : Patients referred for consciousness assessment were prospectively screened. MCS (target condition) was defined according to the best Coma Recovery Scale-Revised score (CRS-R) obtained from expert physicians (reference standard). "DoC-feeling" score was defined as the median of individual subjective reports pooled from multiple staff members during a week of hospitalisation (index test). Individual ratings were collected at the end of each shift using a 100mm visual analog scale, blinded from the reference standard. Diagnostic accuracy was evaluated using area under the receiver operating characteristic curve (AUC), sensitivity and specificity metrics. RESULTS : 692 ratings performed by 83 nursing staff members were collected from 47 patients. Twenty patients were in a UWS and 27 in a MCS. DoC-feeling scores obtained by pooling all individual ratings obtained for a given patient were significantly greater in MCS than in UWS patients (59.2 mm [IQR: 27.3-77.3] vs. 7.2 mm [IQR: 2.4-11.4]; p<0.001) yielding an AUC of 0.92 (95%CI: 0.84-0.99). CONCLUSIONS: DoC-feeling capitalizes on the expertise of nursing staff to evaluate patients' consciousness. Together with the CRS-R as well as with brain imaging, DoC-feeling might improve diagnostic and prognostic accuracy of DoC patients.
Data from: Ophthalmologic evaluation of severely obese patients undergoing bariatric surgery: a pilot, monocentric, prospective, open-label study
Purpose: The aim of this study was to investigate the pathogenic role of obesity on blinding eye diseases in a population of severely obese patients with no history of eye diseases, and to verify whether weight loss induced by bariatric surgery may have a protective effect. Methods: This was a pilot, monocentric, prospective, and open label study conducted at the University Hospital of Pisa. Fifty-seven severely obese patients with a mean body mass index value of 44.1 ± 6 kg/m2 were consecutively recruited and received a complete ophthalmological evaluation and optical coherence tomography. Twenty-nine patients who underwent gastric bypass were evaluated also 3 months, and 1 year after surgery. Results: At baseline, blood pressure value were directly and significantly related to intraocular pressure values (p<0.05, R = 0.35). Blood pressure values were also significantly and inversely related to retinal nerve fiber layer thickness, particularly in the temporal sector (RE p<0.05 r-0.30; LE p<0.01, R = -0.43). Moreover, minimum foveal thickness values were significantly and inversely associated with body mass index (RE p<0.02, R = -0.40; LE p<0.02, R = -0.30). A significant reduction of body mass index (p<0.05) and a significant (p<0.05) improvement of blood pressure was observed three months and one year after gastric bypass, which were significantly associated with an increase in retinal nerve fiber layer thickness and minimum foveal thickness values in both eyes (p<0.05). Conclusions: The results of this study suggest that obese patients may have a greater susceptibility to develop glaucomatous optic nerve head damage and age-related macular degeneration. Moreover, weight reduction and improvement of comorbidities obtained by bariatric surgery may be effective in preventing eye disease development by improving retinal nerve fiber layer and foveal thickness.
Development of chronic pain after posterolateral and axillary approaches for thoracic surgery: A prospective monocentric observational study
<p class="MDPI17abstract"><span>Mini-invasive thoracotomies may reduce chronic</span><span> pain and pain-related functional impairment. The aims of part 2 of the study were to assess their incidence after posterolateral and axillary thoracotomies and to identify potential factors of chronic pain. Patients undergoing a posterolateral (79 patients) or axillary (79 patients) thoracotomy between July 2014 and November 2015 were analyzed in this prospective monocentric cohort study. At the 4-month assessment, more patients had chronic pain in the posterolateral group (60.8% vs 40.5%; p=0.017). There was a significant difference between groups favoring the axillary group: less level of catastrophism (p=0.021) and less impact of pain on daily activities (globally, p=0.009; routine activities subscore, p=0.010, chosen activity subscore, p=0.030). According to a multinomial logistic model multivariable, three factors are associated with the presence of chronic pain: the presence of pain before surgery (OR=2.36, CI 95% [1.03-5.39]), a large posterolateral incision (OR=4.14 [1.25-13.72]) and the intensity of pain during mobilization of the ipsilateral shoulder at postoperative day 6 (OR=1.37 [1.10-1.70]). In conclusion, chronic pain is less frequent after an axillary approach than after a posterolateral one. Identified risk factors for chronic pain should lead to more aggressive management of preoperative and early postoperative pain and favor the mini-invasive approach.</span></p>
Early postoperative pain trajectories after posterolateral and axillary approaches for thoracic surgery: A prospective monocentric observational study
<p class="MDPI17abstract"><span>Less invasive thoracotomies may reduce early postoperative pain. The aims of this study were to identify pain trajectories from postoperative day 0 to 5 after posterolateral and axillary thoracotomies and identify potential factors related to the worst" trajectory. Patients undergoing a posterolateral (92 patients) or axillary (89 patients) thoracotomy between July 2014 and November 2015 were analyzed in this prospective monocentric cohort study. The best-fitting model resulted in four pain trajectory groups: trajectory 1, the "worst", with 29.8% of the patients with permanent significant pain; trajectory 2 with patients with low pain (32.6%), trajectory 3 with patients with a steep decrease in pain (22.7%), trajectory 4 with patients with a steep increase (14.9%). According to a multinomial logistic model multivariable analysis, some predictive factors allow differentiation between trajectory groups 1 and 2. Risk factors for permanent pain are the existence of preoperative pain (OR =6.94, CI 95% [1.54-31.27]) and scar length (OR=1.20 [1.05-1.38])). In contrast, ASA class III is a protective factor to be in group 1 (OR=0.02 [0.001-0.52]). In conclusion, early postoperative pain can be characterized by four trajectories and preoperative pain is the major factor for the worst trajectory of early postoperative pain.</span></p>
BANCO Study: Behavioral Addictions and Related NeuroCOgnitive Aspects: A Monocentric, Prospective, Controlled, Open-label Study of a Sample of Patients With Gambling Disorder
ClinicalTrials.gov study NCT03202290. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effect of Oxiris® Membrane on Microcirculation Following Cardiac Surgery Under Cardiopulmonary Bypass: a Pilot Prospective Monocentric Study (Oxicard Study).
ClinicalTrials.gov study NCT04201119. IPD Sharing: NO. Countries: 1. Publications: 2.
Monocentric STUDY, Randomised Double Blinded (Healthy Subjects, or Transversal (Patients With Gitelman Syndrome)
ClinicalTrials.gov study NCT02297048. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Drainage Fluid Biomarkers and Anastomotic Leakage in Colorectal Surgery. A Monocentric Prospective Observational Study
ClinicalTrials.gov study NCT04846283. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.
Risk Factors for Human Corneal Graft Failure : a Monocentric Retrospective Observational Cohort
ClinicalTrials.gov study NCT04791696. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Monocentric Prospectiv Observational Clinical Trial of Pelvic Floor Biometry During Pregnancy and Puerperium
ClinicalTrials.gov study NCT06867341. IPD Sharing: YES. Countries: 1. Publications: 2.
Monocentric Phase 1 Study With Escalation of Doses of Tocilizumab in Combination With Chemotherapy (Idarubicin and Cytarabine) in Patients With Acute Myeloblastic Leukemia (AML)
ClinicalTrials.gov study NCT04547062. IPD Sharing: NO. Countries: 1. Publications: 1.
Impact of Preoperative Single Corticosteroid Flash on Morbidity After Colorectal Resection: Monocentric Prospective Pilot Study
ClinicalTrials.gov study NCT03437746. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prospective, Monocentric, Interventional Study on Spontaneous Vaginal Clearance of Mycoplasma Genitalium
ClinicalTrials.gov study NCT04841408. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Monocentric Registry to Investigate the Role of Platelet Function, Platelet Genetics, Proteomics and Metabonomics in Heart Disease
ClinicalTrials.gov study NCT01417884. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Feasibility of Prostatic Arterial Embolization in Low-risk Patients With Unilateral Prostate Cancer Under Active Surveillance: Monocentric Pilot Study
ClinicalTrials.gov study NCT03407963. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.