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341 results for “muscle stem cell”
Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signatures
<p>The muscle stem cell (MuSC) population is recognized as functionally heterogeneous. Cranial muscle stem cells, which originate from head mesoderm, can have greater proliferative capacity in culture and higher regenerative potential in transplantation assays when compared to those in the limb. The existence of such functional differences in phenotypic outputs remain unresolved as a comprehensive understanding of the underlying mechanisms is lacking. We addressed this issue using a combination of clonal analysis, live imaging, and scRNA-seq, identifying critical biological features that distinguish extraocular (EOM) and limb (Tibialis anterior, TA) MuSC populations. Time-lapse studies using a MyogenintdTomato reporter showed that the increased proliferation capacity of EOM MuSCs is accompanied by a differentiation delay in vitro. Unexpectedly, in vitro activated EOM MuSCs expressed a large array of distinct extracellular matrix (ECM) components, growth factors, and signaling molecules that are typically associated with mesenchymal non-muscle cells. These unique features are regulated by a specific set of transcription factors that constitute a coregulating module. This transcription factor network, which includes Foxc1 as one of the major players, appears to be hardwired to EOM identity as it is present in quiescent adult MuSCs, in the activated counterparts during growth and retained upon passages in vitro. These findings provide insights into how high-performing MuSCs regulate myogenic commitment by active remodeling of their local environment.</p>
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle
ClinicalTrials.gov study NCT03878992. IPD Sharing: NO. Countries: 1. Publications: 12.
Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signatures
Open the record for dataset details and reuse information.
Transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states
Open the record for dataset details and reuse information.
Dysfunctions of Human Muscle Stem Cells in Sepsis
ClinicalTrials.gov study NCT02789995. IPD Sharing: NO. Countries: 1. Publications: 2.
Clinical Study on Mesenchymal Stem Cells Used in the Reconstruction Surgery of the Supraspinatus Muscle Lesions
ClinicalTrials.gov study NCT03068988. IPD Sharing: NO. Countries: 1. Publications: 5.
Effects of Aerobic Training and Inspiratory Muscle Training in Patients During Hematopoietic Stem Cell Transplantation
ClinicalTrials.gov study NCT03373526. IPD Sharing: NO. Countries: 1. Publications: 8.
Stem Cell Recruitment in Exercised Skeletal Muscles of Older Women by Phytosteroid Rg1
ClinicalTrials.gov study NCT07093190. IPD Sharing: YES. Countries: 1. Publications: 1.
Muscle Stimulation for Physical Function During Stem Cell Transplant
ClinicalTrials.gov study NCT04364256. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Feasibility of Electrical Muscle Stimulation During Stem Cell Transplantation or Intensive Chemotherapy
ClinicalTrials.gov study NCT03467087. IPD Sharing: NO. Countries: 0. Publications: 8.
Inspiratory Muscle Training in Allogeneic Hematopoietic Stem Cell Transplantation Recipients
ClinicalTrials.gov study NCT02270346. IPD Sharing: Not stated. Countries: 0. Publications: 5.
Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist [RNA-seq]
GEO Series GSE132189. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The E3 Ubiquitin Ligase Nedd4L Acts as a Checkpoint Against Activation in Quiescent Muscle Stem Cells
GEO Series GSE230622. Mus musculus. 19 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy
GEO Series GSE307443. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Enhancer rewiring orchestrates inflammation and loss of cell identity during muscle stem cell aging [RNA-seq]
GEO Series GSE293130. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo
GEO Series GSE178981. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Lack of dystrophin disrupts fetal muscle stem cell polarity and commitment during secondary myogenesis
GEO Series GSE274925. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Pax7 remodels the chromatin landscape in skeletal muscle stem cells
GEO Series GSE89977. Mus musculus. 42 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence
GEO Series GSE103603. Mus musculus. 5 samples. Type: Other.
ATAC-Seq of WT and Nedd4L-cKO Muscle stem cells
GEO Series GSE230620. Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.