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50 results for “mycobacterium abscessus”
Data from: Bacteriophage infection and killing of intracellular Mycobacterium abscessus
<p><em>Mycobacterium</em> <em>abscessus</em> is a nontuberculous mycobacterium (NTM) that contributes to the decline and death of patients with lung diseases such as cystic fibrosis and other muco-obstructive airway diseases. <em>M. abscessus</em> is challenging to treat due to its extensive antibiotic resistance and ability to survive inside mammalian cells. An alternative to antibiotics is the therapeutic use of bacteriophages (phages). There are recent cases of phage therapy being used to treat <em>M. abscessus</em> infections in people under compassionate-use conditions. However, little is known about the ability of phages to kill bacteria, such as <em>M. abscessus</em>, that reside in an intracellular environment. Here, we used <em>M. abscessus</em> strains and phages from recent phage therapy cases to determine if phages can enter mammalian cells and if they can infect and kill intracellular <em>M. abscessus</em>. Using fluorescence microscopy, we demonstrate phage uptake by macrophages and lung epithelial cells, and we further demonstrate phage infection of intracellular <em>M. abscessus</em> with fluorescent reporter phages. Transmission electron microscopy was additionally used to image phage infection of intracellular <em>M. abscessus</em>. Together, these findings provide the first visualizations of phage-<em>M. abscessus</em> interactions in an intracellular environment. Finally, we show that phage treatment can significantly reduce the intracellular burden of <em>M. abscessus</em> in a manner that depends on both the specific phage and mammalian cell type involved. These results demonstrate the potential to use phage therapy to treat intracellular bacteria, specifically <em>M. abscessus</em>, while also highlighting the importance of prescreening phage therapy candidates for activity in an intracellular environment.</p>
Oral Omadacycline vs. Placebo in Adults With NTM Pulmonary Disease Caused by Mycobacterium Abscessus Complex (MABc)
ClinicalTrials.gov study NCT04922554. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Bacteriophage infection and killing of intracellular Mycobacterium abscessus
Open the record for dataset details and reuse information.
Finding the Optimal Regimen for Mycobacterium Abscessus Treatment
ClinicalTrials.gov study NCT04310930. IPD Sharing: YES. Countries: 7. Publications: 1.
Epetraborole in Patients With Mycobacterium Abscessus Lung Disease
ClinicalTrials.gov study NCT07301320. IPD Sharing: NO. Countries: 1. Publications: 9.
Liposomal Amikacin for Inhalation (LAI) in the Treatment of Mycobacterium Abscessus Lung Disease
ClinicalTrials.gov study NCT03038178. IPD Sharing: NO. Countries: 1. Publications: 1.
Bacteriophage Therapy for Mycobacterium Abscessus Pulmonary Infection
ClinicalTrials.gov study NCT07228702. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
ALA_PDT promotes the ferroptosis-like death of Mycobacterium abscessus and antibiotic sterilization via oxidative stress
GEO Series GSE193092. Mycobacteroides abscessus. 9 samples. Type: Expression profiling by high throughput sequencing.
Bronchial Epithelial cells gene expression profiles in response to Mycobacterium abscessus
GEO Series GSE140437. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
An integrated approach combining RNA-seq, Ribo-seq and Proteomics identifies the coding potential of Mycobacterium abscessus
GEO Series GSE72996. Mycobacteroides abscessus ATCC 19977. 6 samples. Type: Expression profiling by high throughput sequencing.
Hierarchy and interconnected networks in the WhiB7 mediated transcriptional response of Mycobacterium abscessus to ribosome targeting antibiotics
GEO Series GSE233690. Mycobacteroides abscessus. 16 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Mycobacterium abscessus biofilms have a distinct transcription profile and harbor long-chain mycolic acids
GEO Series GSE165352. Mycobacteroides abscessus ATCC 19977. 20 samples. Type: Expression profiling by high throughput sequencing.
Overlap in antibiotic stress responses leads to cross-resistance between ribosomal acting drugs in Mycobacterium abscessus.
GEO Series GSE163621. Mycobacteroides abscessus. 50 samples. Type: Expression profiling by high throughput sequencing.
Spectinomycin Analogs for the Treatment of Mycobacterium abscessus Infections
GEO Series GSE222081. Mycobacteroides abscessus ATCC 19977. 18 samples. Type: Expression profiling by high throughput sequencing.
Mice lung gene expression profiles in response to Mycobacterium abscessus
GEO Series GSE140438. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
IFN-γ induced the formation of foamy macrophages by CD40 signaling control during Mycobacterium abscessus pulmonary infection
GEO Series GSE287681. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
Ouabain alleviates Mycobacterium abscessus-triggered inflammatory responses through dual regulation of NLRP3 inflammasome activity and M1 macrophage polarization
GEO Series GSE301915. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
New rapid scheme for distinguishing subspecies of the Mycobacterium abscessus group and identification of Mycobacterium massiliense with inducible clarithromycin resistance
GEO Series GSE43629. Mycobacteroides abscessus; Mycobacteroides abscessus subsp. bolletii. 5 samples. Type: Genome variation profiling by genome tiling array.
Transcriptome of Mycobacterium abscessus in response to transition metals
GEO Series GSE243031. Mycobacteroides abscessus. 12 samples. Type: Expression profiling by high throughput sequencing.
Human pluripotent stem cell-derived macrophages host Mycobacterium abscessus infection
GEO Series GSE207456. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.