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ShareScore release 0.9.0
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9 results for “myelin basic protein”
Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
The central nervous system (CNS) insults may cause massive demyelination and lead to the release of myelin-associated proteins including its major component myelin basic protein (MBP). MBP is reported to induce glial activation but its effect on neurons is still little known. Here we found that MBP specifically bound to the extracellular surface of the neuronal plasma membrane and induced neurotoxicity in vitro. This effect of MBP on neurons was basicity-dependent because the binding was blocked by acidic lipids and competed by other basic proteins. Further studies revealed that MBP induced damage to neuronal membrane integrity and function by depolarizing the resting membrane potential, increasing the permeability to cations and other molecules, and decreasing the membrane fluidity. At last, artificial liposome vesicle assay showed that MBP directly disturbed acidic lipid bilayer and resulted in increased membrane permeability. These results revealed that MBP induces neurotoxicity through its direct interaction with acidic components on the extracellular surface of neuronal membrane, which may suggest a possible contribution of MBP to the pathogenesis in the CNS disorders with myelin damage.
Data from: Myelin basic protein induces neuron-specific toxicity by directly damaging the neuronal plasma membrane
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Immunodominant myelin basic protein fragments induce mechanical hypersensitivity.
GEO Series GSE34868. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Myelin-Associated Oligodendrocytic Basic Protein-Dependent Myelin Repair Confers the Long-lasting Antidepressant Effect of Ketamine
GEO Series GSE214861. Mus musculus. 4 samples. Type: Other.
Efficacy and Mechanism of High-Dose Vitamin D Supplementation in Pediatric OAB-Dry: A Randomized Clinical Trial Integrating Urinary Myelin Basic Protein as a Theranostic Biomarker
ClinicalTrials.gov study NCT06489951. IPD Sharing: NO. Countries: 1. Publications: 0.
Gene Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)
GEO Series GSE39119. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
Oligodendroglial precursor cell line [Oli-neu] undergoing differentiation into myelin basic protein-producing cells
GEO Series GSE14406. Mus musculus. 54 samples. Type: Expression profiling by array.
Gene expression profiling of CD4+myelin basic protein specific T cells
GEO Series GSE38645. Rattus norvegicus. 22 samples. Type: Expression profiling by array.
Exon Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)
GEO Series GSE39120. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.