Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
70
datasets available to search
ShareScore release 0.9.0
Dataset results
70 results for “myelopathy”
Degenerative Cervical Myelopathy (DCM) induces sex-specific dysbiosis in the mouse gut bacterial microbiome, altering abundance and function
<p><strong>Background:</strong> Degenerative cervical myelopathy (DCM) represents the commonest cause of spinal cord impairment induced by non-traumatic events in the elderly population. It describes a spectrum of disorders that cause progressive spinal cord compression, neurological impairment, loss of bladder and bowel functions, as well as gastrointestinal dysfunction. The gut microbiota has been increasingly recognized as an environmental factor that can modulate both the central nervous system and immune response through the microbiota-gut-brain axis. Changes in gut microbiota composition or in the microbiota producing factors have been linked in the progression and development of several different pathologies such as traumatic spinal cord injury (SCI). Little is known about the molecular mechanisms that trigger DCM manifestation, and the potential role of the gut microbiota.</p> <p><strong>Results: </strong>Herein DCM was induced in female and male C57BL/6 mice by implanting an aromatic polyether material underneath the C5-6 laminae. The extent of DCM-induced changes in microbiota composition, also known as dysbiosis, was assessed by 16S rRNA sequencing from fecal samples at 3 different time points (6, 9 and 12 weeks after DCM induction). Several bacterial members were identified based on BLAST against the largest collection of metagenome-derived genomes from the mouse gut up to date. In both, female and males DCM caused gut dysbiosis compared with the sham group. However, dysbiosis was more pronounced in males than females, where several bacterial members of the families <em>Lachnospiraceae</em> and <em>Muribaculaceae</em> were significantly altered in the DCM group. These changes were also associated with altered immune cell composition in gut-associated lymphoid tissue, blood, and microbe-derived metabolic changes in propionate, butyrate, and lactate-producing bacterial members.</p> <p><strong>Conclusions: </strong>Our results demonstrate for the first time that DCM causes dynamic changes over time in the gut microbiota. Furthermore, we identify specie-specific abundance changes during DCM progression. DCM strongly reduces the abundance of butyrate-producing bacteria, and lactate-producing bacteria in much less extent. Sequence-based pangenomics cores were not resolved between the latter bacteria, but the gap-filling reactions and metabolic modelling successfully identified pyruvate-to-butanoate and pyruvate-to-propionate genes such as Buk and ACH1, respectively. These results aid to better understand markers and the molecular mechanisms that over time trigger DCM manifestation in females and males.</p>
Cervical Spondylotic Myelopathy Surgical Trial
ClinicalTrials.gov study NCT02076113. IPD Sharing: YES. Countries: 2. Publications: 6.
Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP)
ClinicalTrials.gov study NCT00773292. IPD Sharing: NO. Countries: 1. Publications: 1.
Hand Dexterity Training in Degenerative Cervical Myelopathy (DCM)
ClinicalTrials.gov study NCT06754072. IPD Sharing: NO. Countries: 1. Publications: 1.
The reliability and validity of an Arabic version of the modified Japanese Orthopedic Association score for cervical myelopathy
<p><b>Purpose: </b>The modified Japanese Orthopedic Association score (mJOA) is considered as one of the most comprehensive scores in assessment of patients with cervical myelopathy. Hence, comes the need for providing a validated, translated and cross-culturally adapted versions in different languages in order to standardize patient's evaluation. This study aims to translate and validate an Arabic version of the mJOA.</p> <p><b>Methods: </b>65 patients of variable age and etiologies for compressive cervical myelopathy were recruited. Forward and backward translations were performed, followed by measurement of intra-observer and inter-observer reliability using intra-class correlation coefficient and Cronbach's alpha coefficient.</p> <p><b>Results: </b>The patients had a mean age of 58.08, predominantly males (69.2%). The intra-observer reliability and inter-observer reliability showed almost perfect agreement for the different sections and the total score, with 96.8 and 97.4, respectively.</p> <p><b>Conclusion: </b>This study provides a reliable, cross-culturally adapted Arabic version of mJOA for cervical myelopathy patients. Although the study was conducted on Egyptian patients, we believe it could be implemented with majority of Arabic speaking population.</p>
Surgical Treatment of Cervical Spondylotic Myelopathy
ClinicalTrials.gov study NCT00565734. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Reorganization of Brain Functions in Patients With Cervical Myelopathy Using fMRI and MRS
ClinicalTrials.gov study NCT00447343. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Cervical Laminectomy With or Without Lateral Mass Fixation in Cervical Spondylotic Myelopathy
ClinicalTrials.gov study NCT06045663. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Quantiative MRI and Myelin-PET for the Assessment of Degenerative Cervical Myelopathy
ClinicalTrials.gov study NCT05242666. IPD Sharing: NO. Countries: 1. Publications: 1.
Rituximab for HTLV-1-associated Myelopathy
ClinicalTrials.gov study NCT04004819. IPD Sharing: Not stated. Countries: 1. Publications: 1.
DTI of the Brain and Cervical Spine: Evaluation in Normal Subjects and Patients With Cervical Spondylotic Myelopathy
ClinicalTrials.gov study NCT01868958. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Gait in Adult Patients With Cervical Spondylotic Myelopathy
ClinicalTrials.gov study NCT03513679. IPD Sharing: NO. Countries: 1. Publications: 28.
Regeneration in Cervical Degenerative Myelopathy
ClinicalTrials.gov study NCT04631471. IPD Sharing: NO. Countries: 1. Publications: 80.
Safety Study of Preservon-Treated Bone Implants for Cervical Fusion in the Treatment of Cervical Radiculopathy or Myelopathy
ClinicalTrials.gov study NCT00344890. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cervical Spondylotic Myelopathy - Cost Observational Surgical Trial
ClinicalTrials.gov study NCT05994404. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM)
ClinicalTrials.gov study NCT03191526. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy of Riluzole in Surgical Treatment for Cervical Spondylotic Myelopathy (CSM-Protect)
ClinicalTrials.gov study NCT01257828. IPD Sharing: Not stated. Countries: 2. Publications: 5.
Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)
ClinicalTrials.gov study NCT00001785. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Fusion or no Fusion After Decompression of the Spinal Cord in Patients With Degenerative Cervical Myelopathy
ClinicalTrials.gov study NCT04936074. IPD Sharing: NO. Countries: 1. Publications: 31.
Predictors of Outcome and Natural History in Patients With Cervical Spondylotic Myelopathy
ClinicalTrials.gov study NCT02936245. IPD Sharing: YES. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.