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455 results for “neoplasia”
Deterministic evolution and stringent selection during pre-neoplasia
<p>The earliest events during human tumor initiation, while poorly characterized, may hold clues to malignancy detection and prevention. Here we model occult pre-neoplasia by bi-allelically inactivating <em>TP53</em>, a common early event in gastric cancer, in human gastric organoids. Causal relationships between this initiating genetic lesion and resulting phenotypes were established using experimental evolution in multiple clonally derived cultures over two years. <em>TP53</em> loss elicited progressive aneuploidy, including copy number alterations and structural variants prevalent in gastric cancers, with evident preferred orders. Longitudinal single cell sequencing of <em>TP53</em> deficient gastric organoids similarly indicates progression towards malignant transcriptional programs. Moreover, high-throughput lineage tracing with expressed cellular barcodes demonstrates reproducible dynamics whereby initially rare subclones with shared transcriptional programs repeatedly attain clonal dominance. This powerful platform for experimental evolution exposes stringent selection, clonal interference, and a striking degree of phenotypic convergence in pre-malignant epithelial organoids. These data imply predictability in the earliest stages of tumorigenesis and reveal evolutionary constraints and barriers to malignant transformation with implications for earlier detection and interception of aggressive, genome instable tumors.</p>
Cervical intraepithelial neoplasia acetic acid white images - pre-cancerous lesion three-class classification
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MORBIMORTALIDADE POR NEOPLASIA DE ESÔFAGO NO ESTADO DO PIAUÍ: ANÁLISE DOS ANOS DE 2018 – 2022
<p>INTRODUÇÃO: O câncer de esôfago é uma condição maligna do revestimento interno do esôfago e tem como principais fatores de risco: idade, tabagismo, etilismo, ingesta de vegetais em conserva e de bebidas aquecidas. Destaca-se também os dois principais tipos histológicos Carcinoma Escamoso (CEC) e o Adenocarcinoma. METODOLOGIA: Trata-se de um estudo epidemiológico retrospectivo, de caráter descritivo e natureza quantitativa. Para essa finalidade, foram utilizados os dados disponibilizados pelo Sistema de Informações sobre Morbidade Hospitalar do SUS (SIH/SUS) pertencentes aos casos de Mortalidade Hospitalar por neoplasia de esôfago no estado do Piauí entre os anos de 2018 e 2022. RESULTADOS: Entre os anos de 2018 a 2022, foram internados 939 pacientes, dos quais 464 (49,41%) foram internações eletivas e 475 (50,58%) como urgência. Em 2019, observa-se o maior número de internações. No entanto, em 2018 os valores de serviços hospitalares associados a essas internações foi o mais alto (271.672,21). A média de permanência dos pacientes nos hospitais variou ao longo dos anos. Os óbitos totalizaram 78 ocorrências. A taxa de mortalidade variou consideravelmente em 2018, foi de 4,94%, aumentando progressivamente para 18,33% em 2022.Quanto à faixa etária, a distribuição variou, com a maioria das internações ocorrendo em pacientes com idades entre 50 e 79 anos. DISCUSSÃO: Nesse estudo foi possível discutir as principais descobertas sobre neoplasia de esôfago no Piauí dos últimos cinco anos. Aborda variações em internações, custos hospitalares, mortalidade e características dos pacientes, destacando a necessidade de uma gestão hospitalar adaptável e eficaz. A crescente taxa de mortalidade ao longo dos anos ressalta a importância de avaliar e aprimorar os protocolos de atendimento. Esses resultados são cruciais para orientar políticas de saúde, alocação de recursos e melhorias na qualidade do atendimento, buscando uma prestação de serviços mais eficaz e equitativa. CONCLUSÃO: Este estudo oferece uma análise detalhada das internações hospitalares de 2018 a 2022, destacando variações significativas nos tipos de internações, custos hospitalares, média de permanência, óbitos e características demográficas dos pacientes.</p>
Dose-finding Study of Hexaminolevulinate (HAL) Photodynamic Therapy (PDT) to Treat Cervical Neoplasia
ClinicalTrials.gov study NCT01256424. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Vaccine To Prevent Cervical Intraepithelial Neoplasia or Cervical Cancer in Younger Healthy Participants
ClinicalTrials.gov study NCT00128661. IPD Sharing: Not stated. Countries: 1. Publications: 26.
Screening for Cervical Intraepithelial Neoplasia Using Self-collected Menstrual Blood
ClinicalTrials.gov study NCT03638427. IPD Sharing: NO. Countries: 1. Publications: 1.
Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia
ClinicalTrials.gov study NCT01164722. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Ranibizumab on Malignant Conjunctival Neoplasia
ClinicalTrials.gov study NCT00456495. IPD Sharing: NO. Countries: 1. Publications: 1.
Radiofrequency Ablation for Patients With Esophageal Squamous Cell Neoplasia
ClinicalTrials.gov study NCT02047305. IPD Sharing: NO. Countries: 1. Publications: 3.
Cryotherapy vs. LEEP to Treat Cervical Intraepithelial Neoplasia (CIN) 2/3 Among HIV-positive Women
ClinicalTrials.gov study NCT01298596. IPD Sharing: NO. Countries: 1. Publications: 3.
Study of Polyphenon E in Men With High-grade Prostatic Intraepithelial Neoplasia
ClinicalTrials.gov study NCT00596011. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia)
ClinicalTrials.gov study NCT00106691. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Green Tea Extract in Preventing Cervical Cancer in Patients With Human Papillomavirus and Low-Grade Cervical Intraepithelial Neoplasia
ClinicalTrials.gov study NCT00303823. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Safety and Tolerability of Circumferential Anal Canal Radiofrequency Ablation For Anal Intraepithelial Neoplasia
ClinicalTrials.gov study NCT02189161. IPD Sharing: Not stated. Countries: 1. Publications: 1.
5-fluorouracil Following Cervical Intraepithelial Neoplasia Treatment Among HIV-positive Women in East Africa
ClinicalTrials.gov study NCT05362955. IPD Sharing: NO. Countries: 1. Publications: 3.
Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia
ClinicalTrials.gov study NCT01535053. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Vaccine Therapy in Preventing Cervical Cancer in Patients With Cervical Intraepithelial Neoplasia
ClinicalTrials.gov study NCT00121173. IPD Sharing: Not stated. Countries: 1. Publications: 1.
CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia
ClinicalTrials.gov study NCT01032044. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Celecoxib in Treating Patients With Cervical Intraepithelial Neoplasia
ClinicalTrials.gov study NCT00081263. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A mathematical model for pancreatic cancer during intraepithelial neoplasia
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.