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106 results for “nephrotoxicity”
Data set associated with a research on nephrotoxicity of gasoline fumes in male albino rat: A mechanism-based approach study
<p>Few studies have reported nephrotoxicity of gasoline fumes in animals, but none of the findings has been fully ascertained and the mechanism underlying the observed toxicity still remains unknown. In this study, we present insights into the potential mechanism underlying the nephrotoxicity of gasoline fumes in 72 adult male albino rats. This study showed for the first time that accumulation of gasoline residues and metabolites in the kidney of exposed animal could potentially result in the generation of ROS capable of inducing renal dysfunction. The dataset uploaded are associated with this study. </p>
Evaluate the Nephrotoxicity by 6% Hydroxyethyl Starch 130/0.4 in Old Patients During Orthopaedic Surgery
ClinicalTrials.gov study NCT02361736. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy
ClinicalTrials.gov study NCT01848457. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Data from:Investigation of urinary miRNA profile changes in amphotericin B-induced nephrotoxicity in C57BL/6 mouse, Sprague-Dawley rats and beagle dogs
Open the record for dataset details and reuse information.
Screening the Sigma LOPAC®1280 library of compounds for protective effects against cisplatin-induced oto- and nephrotoxicity
<p>Dose-limiting toxicities for cisplatin administration, including ototoxicity and nephrotoxicity, impact the clinical utility of this effective chemotherapy agent and lead to lifelong complications, particularly in pediatric cancer survivors. Using a two-pronged drug screen employing the zebrafish lateral line as an <i>in vivo</i> readout for ototoxicity and kidney cell-based nephrotoxicity assay, we screened 1280 compounds and identified 22 that were both oto- and nephroprotective. Of these, dopamine and L-mimosine, a plant-based amino acid active in the dopamine pathway, were further investigated. Dopamine and L-mimosine protected the hair cells in the zebrafish otic vesicle from cisplatin-induced damage and preserved zebrafish larval glomerular filtration. Importantly, these compounds did not abrogate the cytotoxic effects of cisplatin on human cancer cells. This study provides insights into the mechanisms underlying cisplatin-induced oto- and nephrotoxicity and compelling preclinical evidence for the potential utility of dopamine and L-mimosine in the safer administration of cisplatin.</p>
Contrast-inDuced nephRotoxicity as Assessed by the KIdney Load-to-DAmage RElationship
ClinicalTrials.gov study NCT01908309. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Ascorbic Acid for Prevention of Colistin-Associated Nephrotoxicity
ClinicalTrials.gov study NCT01501968. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Immune Checkpoint Inhibitors Nephrotoxicity
ClinicalTrials.gov study NCT04902846. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety of N-Acetylcysteine Versus Alpha-Lipoic Acid in Colistin-Induced Nephrotoxicity
ClinicalTrials.gov study NCT06650384. IPD Sharing: NO. Countries: 1. Publications: 69.
Is Self-transfusion Safe After Total Knee Arthroplasty in Terms of Nephrotoxicity of Gentamicin From Bone Cement?
ClinicalTrials.gov study NCT04505748. IPD Sharing: NO. Countries: 1. Publications: 4.
Description of the Cystatin C as an Early Nephrotoxic Bio-marker in Pediatric Oncology
ClinicalTrials.gov study NCT02822404. IPD Sharing: NO. Countries: 1. Publications: 1.
Genetic Predisposition-Chronic Nephrotoxicity From CI-Liver Transplant Recipients-Potential Correlation-Urinary Biomarkers
ClinicalTrials.gov study NCT00857844. IPD Sharing: Not stated. Countries: 1. Publications: 35.
Prevention Of Nephrotoxicity Following Bone Marrow Transplantation Using Urodilatin and Mannitol
ClinicalTrials.gov study NCT00390624. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Drug Nephrotoxicity Amelioration by N-acetylcysteine
ClinicalTrials.gov study NCT06122311. IPD Sharing: Not stated. Countries: 1. Publications: 4.
The Effects of Spironolactone on Calcineurin Inhibitor Induced Nephrotoxicity
ClinicalTrials.gov study NCT01602861. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs (NeoAKI STOP)
ClinicalTrials.gov study NCT05851222. IPD Sharing: NO. Countries: 1. Publications: 43.
Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment
ClinicalTrials.gov study NCT04991376. IPD Sharing: NO. Countries: 1. Publications: 4.
Prevention of Cisplatin-induced Nephrotoxicity
ClinicalTrials.gov study NCT06196853. IPD Sharing: NO. Countries: 1. Publications: 4.
Real-time Early Detection of Nephrotoxicity by Urinary Biomarker Analysis With SeroFlow Technology
ClinicalTrials.gov study NCT06124885. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of the Effect of Rosuvastatin on Cisplatin-induced Nephrotoxicity and Ototoxicity
ClinicalTrials.gov study NCT04817904. IPD Sharing: NO. Countries: 1. Publications: 4.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.