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281 results for “network integrity”
Dataset from: Spatially heterogeneous shifts in vegetation phenology induced by climate change threaten the integrity of the avian migration network
<p>Original data and code for the study:</p> <p>Wei, J., Xu, F., Cole, E. F., Sheldon, B. C., de Boer, W. F., Wielstra, B., Fu, H., Gong, P., & Si, Y. (2024, Accepted). Spatially heterogeneous shifts in vegetation phenology induced by climate change threaten the integrity of the avian migration network. Global Change Biology.</p> <p>The dataset mainly contains data showing the climate change-induced heterogeneous shifts in vegetation phenology and the migration integrity change from 2000 to 2020 for 16 Asian herbivorous waterfowl species. These data were derived from the following resources available in the public domain.</p> <p>The Global Lakes and Wetlands Database is available from “https://www.worldwildlife.org/pages/global-lakes-and-wetlands-database”. The global land cover datasets are available from European Space Agency (ESA) Climate Change Initiative (CCI) products, “https://maps.elie.ucl.ac.be/CCI/viewer/download.php”. The Global Multi-resolution Terrain Elevation Data are available from “https://www.usgs.gov/centers/eros/science/terrain-monitoring-and-modeling”. The Moderate Resolution Imaging Spectroradiometer (MODIS) Terra surface reflectance product is available from “https://modis.gsfc.nasa.gov/data/dataprod/mod09.php”. The bird distribution maps are available from Birdlife International, “https://www.birdlife.org/”. The bird foraging attribute data are available from EltonTraits 1.0, “https://figshare.com”. The bird occurrence data are available from eBird Basic Dataset (EBD), “https://science.ebird.org/en/use-ebird-data/download-ebird-data-products”. The Hackett backbone phylogenetic trees are available from “https://birdtree.org/”.</p> <p>The code contains the R scripts and MATLAB scripts that we used for this study.</p> <p>For details please see the file “Readme.txt”, and the research paper.</p>
An integrated approach including docking, MD simulations, and network analysis highlights the action mechanism of the cardiac hERG activator RPR260243
<p>500 ns MD trajectories of the hERG bound states (protein and ligand) used for the analyses discussed in the paper. There are three replica for each system. The trajectories can be visualized using molecular visualization programs such as Pymol or VMD uploading the PDB and the DCD file.</p> <p>The PDB and the topology files of the hERG bound state (protein, membrane, ions and ligand) are also included.</p> <p>An example of input file used for the production step of the dynamics has been provided (production_1.conf). </p>
Determining non-significant bits on a C++ implementation of the LeNet-5 convolutional neural network to be used for storing error correcting codes to protect weights and biases. Robustness assessment of the network after integrating the proposed codes.
<p>The architecture of the LeNet-5 convolutional neural network (CNN) was defined by LeCun in its paper "Gradient-based learning applied to document recognition" (<a href="https://ieeexplore.ieee.org/document/726791">https://ieeexplore.ieee.org/document/726791</a>) to classify images of hand written digits (MNIST dataset).</p><p>This architecture has been customized to use Rectified Linear Unit (ReLU) as activation functions instead of Sigmoid.</p><p>It consists of the following layers:</p><ul><li><strong>conv1</strong>: Convolution 2D, 1 input channel (28x28), 3 output channels (28x28), kernel size 5, stride 1, padding 2.</li><li><strong>relu1</strong>: Rectified Linear Unit (3@28x28).</li><li><strong>max1</strong>: Subsampling buy max pooling (3@14x14).</li><li><strong>conv2</strong>: Convolution 2D, 3 input channels (14x14), 6 output channels (14x14), kernel size 5, stride 1, padding 2.</li><li><strong>relu2</strong>: Rectified Linear Unit (6@14x14).</li><li><strong>max2</strong>: Subsampling buy max pooling (6@7x7).</li><li><strong>fc1</strong>: Fully connected (294, 147)</li><li><strong>fc2</strong>: Fully connected (147, 10)</li></ul><p>The fault hypotheses for this work include the occurrence of:</p><ul><li><strong>S0</strong>/<strong>S1</strong>: multiple adjacent stuck-at-0 and stuck-at-1 faults to determine the least significant bits of weights and biases that could be used to store the proposed error correcting codes.</li><li><strong>BF</strong>: single, double, and triple bit-flip faults to assess the robustness of the considered CNN</li></ul><p>In the memory cells containing all the parameters of the CNN: </p><ul><li><strong>w</strong>: weights (float32)</li><li><strong>b</strong>: biases (float32)</li></ul><p>All the images (10000) from the MNIST dataset have been used as workload.</p><p>The weights and biases of the LeNet-5 architecture have been protected using six different error correcting codes that have been deployed in the least significant bits of these elements.</p><p>The parity check matrices (H = P I) that define these ECCs are:</p><ul><li><strong>SEC(32, 26)</strong> (Hamming) under a <i>classic policy </i>(see methodology below):</li></ul><p><i> 11010010001000011101101000 100000</i></p><p><i> 10101001000100011011010100 010000</i></p><p><i> 01100100100010010110110010 001000</i></p><p><i> 00011100010001001110001101 000100</i></p><p><i> 00000011110000100001111011 000010</i></p><p><i> 00000000001111100000000111 000001</i></p><ul><li><strong>SEC(23, 18)</strong> (Hamming) under a <i>conservative policy</i> (see methodology below):</li></ul><p><i> 111100001111000000 10000</i></p><p><i> 110011101000111000 01000</i></p><p><i> 101011010100100110 00100</i></p><p><i> 010110110010010101 00010</i></p><p><i> 001101110001001011 00001</i></p><ul><li><strong>SEC(13, 9)</strong> (Hamming) under an <i>aggressive policy </i>(see methodology below):</li></ul><p><i> 110111000 1000</i></p><p><i> 101100110 0100</i></p><p><i> 011010101 0010</i></p><p><i> 111001011 0001</i></p><ul><li><strong>DEC(32, 21)</strong> (low redundancy and reduced overhead DEC) under a <i>classic policy </i>(see methodology below):</li></ul><p><i> 111000011001010010000 10000000000</i></p><p><i> 110110000011101000000 01000000000</i></p><p><i> 101011000110000010001 00100000000</i></p><p><i> 100101101000110001000 00010000000</i></p><p><i> 011010101100100000100 00001000000</i></p><p><i> 010101010100001001010 00000100000</i></p><p><i> 001100110010010100100 00000010000</i></p><p><i> 000011110001000110010 00000001000</i></p><p><i> 000000001111001101001 00000000100</i></p><p><i> 000000000000111100111 00000000010</i></p><p><i> 000000000000000011111 00000000001</i></p><ul><li><strong>DEC(28, 18)</strong> (low redundancy and reduced overhead DEC) under a <i>conservative policy </i>(see methodology below):</li></ul><p><i> 111111000000000000 1000000000</i></p><p><i> 110100111100000000 0100000000</i></p><p><i> 110000100011110000 0010000000</i></p><p><i> 001110010011001100 0001000000</i></p><p><i> 101100001010101010 0000100000</i></p><p><i> 010001001101010110 0000010000</i></p><p><i> 001011000101101001 0000001000</i></p><p><i> 101000011000110101 0000000100</i></p><p><i> 010001110000011011 0000000010</i></p><p><i> 000010100110000111 0000000001</i></p><ul><li><strong>DEC(17, 9)</strong> (low redundancy and reduced overhead DEC) under an <i>aggressive policy </i>(see methodology below):</li></ul><p><i> 111110000 10000000</i></p><p><i> 111001100 01000000</i></p><p><i> 110101010 00100000</i></p><p><i> 101010110 00010000</i></p><p><i> 101101001 00001000</i></p><p><i> 100110101 00000100</i></p><p><i> 100011011 00000010</i></p><p><i> 110000111 00000001</i></p><p>This dataset contains the raw data obtained from:</p><ul><li>running exhaustive fault injection campaigns for increasingly multiple stuck-at faults in the least significant bits of all weights and biases (simultaneously) and for all the images in the workload.</li><li>running statistical fault injection campaigns for single, double, and triple bit-flip faults, randomly targeting the considered locations and images in the workload.</li></ul><h3>Files information</h3><ul><li><i>no_ecc </i>folder: Results obtained for the original (not protected) version of the CNN.<ul><li><i>golden_run.csv</i>: Prediction obtained for all the images considered in the workload in the absence of faults (Golden Run). This is intended to act as oracle to determine the impact of injected faults.</li><li><i>sampling_SBF_10000.csv</i>: Prediction obtained for running 10000 statistical fault injection experiments for single bit-flip faults.</li><li><i>sampling_DBF_10000.csv</i>: Prediction obtained for running 10000 statistical fault injection experiments for double bit-flip faults.</li><li><i>sampling_TBF_10000.csv</i>: Prediction obtained for running 10000 statistical fault injection experiments for triple bit-flip faults.</li><li><i>locating_sensitive_bits </i>folder: Prediction obtained for all the images considered in the workload in presence of stuck-at-0/stuck-at-1 faults that simultaneously target the N least significant bits of all weights and biases. There is one file for each parameter of type of fault and range of targeted bits. Files for bits in the range [11, 0] are not included as they obtain eactly the same results as the Golden Run (faults do not alter the behaviour of the network).</li></ul></li><li><i>sec/classic</i>, <i>sec/conservative</i>, and <i>sec/aggressive</i> folders: They contain the results obtained for the CNN protected by SEC(32, 26), SEC(23, 18), and SEC(13, 9), respectively.<ul><li><i>golden_run.csv</i>: Prediction obtained for all the images considered in the workload in the absence of faults (Golden Run). This is intended to act as oracle to determine the impact of injected faults. It must be noted that this file could be different that the golden_run.csv file for the original version of the CNN, as deploying the ECC in the weights and biases may have affected the behaviour of the network.</li><li><i>sampling_SBF_10000.csv</i>: Prediction obtained for running 10000 statistical fault injection experiments for single bit-flip faults. They should all be tolerated by the definition of the ECC.</li><li><i>sampling_DBF_10000.csv</i>: Prediction obtained for running 10000 statistical fault injection experiments for double bit-flip faults. They could be more harmful than for the unprotected version of the CNN, as the ECC may erroneously flip correct bits.</li></ul></li><li><i>dec/classic</i>, <i>dec/conservative</i>, and <i>dec/aggressive </i>folders: They contain the results obtained for the CNN protected by DEC(32, 21), DEC(28, 18), and DEC(17, 9), respectively.<ul><li><i>golden_run.csv</i>: Prediction obtained for all the images considered in the workload in the absence of faults (Golden Run). This is intended to act as oracle to determine the impact of injected faults. It must be noted that this file could be different that the golden_run.csv file for the original version of the CNN, as deploying the ECC in the weights and biases may have affected the behaviour of the network.</li><li><i>sampling_DBF_10000.csv</i>: Prediction obtained for running 10000 statistical fault injection experiments for double bit-flip faults. They should all be tolerated by the definition of the ECC.</li><li><i>sampling_TBF_10000.csv</i>: Prediction obtained for running 10000 statistical fault injection experiments for triple bit-flip faults. They could be more harmful than for the unprotected version of the CNN, as the ECC may erroneously flip correct bits.</li></ul></li></ul><h3>Methodology information</h3><p>First, the CNN was used to classify all the images of the workload in the absence of faults to get a reference to determine the impact of faults. This is <i>golden_run.csv</i> file.</p><p>To locate non-significant bits in weights and biases, fault injection experiments were executed targeting all elements of all parameters of the CNN using the following procedure:</p><ul><li>The initial mask targeted only the least significant bit</li><li>Until the mask targets all bits of the elements (32 bits as they are single-precision floating point values):<ul><li>Affect the bits (setting them to 0 or 1 in case of stuck-at-0 or stuck-at-1 faults) identified by the mask for all elements of all parameters.</li><li>Classify all the images of the workload in the presence of this fault. The obtained output was stored in a given .csv file.</li><li>Remove the fault from the CNN by restoring the affected bits to its previous value.</li><li>Add the next adjacent bit to the mask, so it targets an additional least significant bit.</li></ul></li></ul><p>The analysis of the obtained results may help in determining which bits can be used to store an ECC:</p><ul><li>which bits never affect the behaviour of the CNN, as the predicted classification is exactly the same than in the absence of faults.</li><li>which bits midly affect the behaviour of the CNN, as although the predicted classifications differ from those in the absence of faults, the accuracy of the network is barely affected.</li><li>which bits greatly affect the behaviour of the CNN, as the accuracy of the network is significantly affected.</li></ul><p>Accordingly, three different policies have been identified for deploying an ECC using these bits:</p><ul><li><strong>Classic policy</strong>: The ECC protects as much bits as possible.</li><li><strong>Conservative policy</strong>: The ECC protects all those bits that may affect the prediction of the network.</li><li><strong>Aggressive policy</strong>: The ECC protects only those bits that significantly affect the accuracy of the network.</li></ul><p>After designing and deploying a single ECC and a double ECC for each of the identified policies, fault injection experiments were executed to verify their behaviour in the presence of faults.</p><p>Single and double ECCs were tested against single and double bit-flip, respectively (all faults should be tolerated,) and double and triple bit-flips, respectively (a correct bit could be erroneously flipped.)</p><p>Due to the heavy computational load of the decoders, statistical injection was used to run the required fault injection campaigns with a sample size (number of experiments) of 10000.</p><p>Each experiment consisted in:</p><ul><li>Randomly selecting the image to process, and the parameter, element, and bits (mask) to be targeted by the fault.</li><li>Affecting the bits (inverting them) identified by the mask.</li><li>Classifying the selected image of the workload in the presence of this fault. The obtained output was stored in a given .csv file.</li><li>Removing the fault from the CNN by restoring the affected bits to its previous value.</li></ul><h3>List of variables (Name : Description (Possible values))</h3><ul><li><strong>IMGID</strong>: Integer number identifying the considered image (1-9999).</li><li><strong>TENSORID</strong>: Integer number identiying the parameter affected by the fault (0 - No fault, 1 - conv1.w, 2 - conv1.b, 3 - conv2.w, 4 - conv2.b, 5 - fc1.w, 6 - fc1.b, 7 - fc2.w, 8 - fc2.b).</li><li><strong>ELEMID</strong>: Integer number identiying the element of the parameter affected by the fault (-1 - No fault, [0-2] - conv1.b, [0-74] - conv1.w, [0-5] - conv2.b, [0-149] - conv2.w, [0-146] - fc1.b, [0-43217] - fc1.w, [0-9] - fc2.b, [0-1469] - fc2.w).</li><li><strong>MASK</strong>: 8-digit hexadecimal number identifying those bits affected by the fault ([00000000 - No fault, FFFFFFFF - all 32 bits faulty]).</li><li><strong>FAULT</strong>: String identiying the type of fault (NF - No fault, BF - bit-flip, S0 - Stuck-at-0, S1 - Stuck-at-1).</li><li><strong>SOFTMAX</strong>: 10 decimal numbers obtained after applying the softmax function to the provided output. They represent the probability of the image of belonging to the corresponding category for classification.</li><li><strong>PRED</strong>: Integer number representing the category predicted for the processed image.</li><li><strong>LABEL</strong>: integer number representing the actual category for the processed image.</li></ul>
Neural Network predictions and ERA5 reference of integrated water vapour, and temperature and specific humidity profiles based on simulated microwave radiometer observations
<p>This data set contains predictions of the Neural Network retrievals described in <strong>[1]</strong>, where simulated microwave radiometer observations (brightness temperatures, TBs) from the evaluation data subset of <strong>[2]</strong> (years 2001, 2006, 2011, 2015) were used as input to the Neural Network. As described in Section 3.2 of <strong>[1]</strong>, we trained an ensemble of 20 Neural Networks for each retrieved atmospheric quantity and applied them to the ERA5 evaluation data set to estimate the robustness of the retrievals with respect to random perturbations. The following atmospheric quantities were retrieved: </p> <ul> <li>temperature profile (variable name 'temp_p', filename suffix 'temp_test_417'),</li> <li>boundary layer temperature profile (variable name 'temp_p', filename suffix 'temp_test_424'),</li> <li>specific humidity profile (variable name 'q_p', filename suffix 'q_test_472'),</li> <li>integrated water vapour (variable name 'iwv_p', filename suffix 'iwv_test_126')</li> </ul> <p>The cryptic 3-digit filename suffixes represent different settings of the Neural Network retrieval. More information can be found in <strong>[3]</strong>. Variables that do not have the "_p" suffix are ERA5 data and used as reference to estimate errors of the retrievals by comparing them with the predictions. The dimension 'n_s' represents the ERA5 data sample number while the dimension 'n_rand' designates the ensemble of Neural Networks.</p> <p>These files can be created when running run_NN_retrieval (contained in NN_retrieval.py, see <strong>[3]</strong>) with exec_type='20_runs' and eval_mode=True and test_id either "126", "417", "424" or "472". However, as this might take some hours, we provide them here.</p> <p> </p> <p><strong>[1]:</strong> Walbröl, A., Griesche, H. J., Mech, M., Crewell, S., and Ebell, K.: Combining low- and high-frequency microwave radiometer measurements from the MOSAiC expedition for enhanced water vapour products, Atmospheric Measurement Techniques, 17, 6223-6245, https://doi.org/10.5194/amt-17-6223-2024, 2024.</p> <p><strong>[2]:</strong> Walbröl, A., and Mech, M.: ERA5 based training, validation and evaluation data for retrievals combining 22-58 GHz with 175-340 GHz microwave radiometer measurements during MOSAiC (1.0.0). Zenodo. https://doi.org/10.5281/zenodo.10997365, 2024.</p> <p><strong>[3]: </strong>Walbröl, A.: Codes for: Combining low and high frequency microwave radiometer measurements from the MOSAiC expedition for enhanced water vapour products (1.0.1). Zenodo. <a href="https://doi.org/10.5281/zenodo.11123136" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.11123136</a>, 2024.</p>
Integrating differential expression and weighted correlation network analysis for identifying genes controlling shoot development in Sorghum bicolor
<p>Supplementery materials of journal article "Integrating differential expression and weighted correlation network analysis for identifying genes controlling shoot development in <em>Sorghum bicolor</em>"</p>
SUBATOMIC analysis of Homo sapiens integrated multi-edge networks
<p>We applied SUBATOMIC (https://github.com/CBIGR/SUBATOMIC/) to analyze a composite <em>H. sapiens</em> network containing transcription factor-target gene, miRNA-target gene, protein-protein, homologous and co-functional interactions from three different databases. We derived and annotated 5586 modules with diverse topological, regulatory and functional properties.</p>
Figure 1. Schema for a data-integration solution-A Proposed Data Driven Architecture for Cardiology Network Application
<p>Data integration has favored loosening the coupling between data. This may involve<br> providing a uniform query interface over a mediated schema (see figure 1), thus transforming<br> a query into specialized queries over the original databases. One can also term this process<br> "view-based query-answering" because each of the data sources functions as a view over the<br> (nonexistent) mediated schema.</p>
Figure 3. Data Integration Sample-A Proposed Data Driven Architecture for Cardiology Network Application
<p>Pentaho Data Integration has implemented a metadata-driven approach where you<br> only specify the data you want integrated, but you do not specify the way you want it done.<br> One of the most important advantages of Pentaho is that one can create complex<br> transformations and jobs in a graphical, drag-and-drop environment without having to create<br> proprietary custom code that will work only with some proprietary application.</p>
netDx: Interpretable patient classification using integrated patient similarity networks
<p>Docker image containing installed netDx software in Ubuntu to reproduce examples from the published manuscript. The R implementation of netDx is hosted at: https://github.com/BaderLab/netDx</p> <p>---<br> Publication abstract: Patient classification has widespread biomedical and clinical applications, including diagnosis, prognosis and treatment response prediction. A clinically useful prediction algorithm should be accurate, generalizable, be able to integrate diverse data types, and handle sparse data. A clinical predictor based on genomic data needs to be easily interpretable to drive hypothesis-driven research into new treatments. We describe netDx, a novel supervised patient classification framework based on patient similarity networks. netDx meets the above criteria and particularly excels at data integration and model interpretability. We compared classification performance of this method against other machine-learning algorithms, using a cancer survival benchmark with four cancer types, each requiring integration of up to six genomic and clinical data types. In these tests, netDx has significantly higher average performance than most other machine-learning approaches across most cancer types. In comparison to traditional machine learning-based patient classifiers, netDx results are more interpretable, visualizing the decision boundary in the context of patient similarity space. When patient similarity is defined by pathway-level gene expression, netDx identifies biological pathways important for outcome prediction, as demonstrated in diverse data sets of breast cancer and asthma. Thus, netDx can serve both as a patient classifier and as a tool for discovery of biological features characteristic of disease. We provide a freely available software implementation of netDx along with sample files and automation workflows in R.</p>
Integrated analysis of miRNA landscape and cellular networking pathways in stage-specific prostate cancer
<p><strong>Figure S1.</strong> Heat map of miRNA-microarray. Expression of miRNAs differentially expressed and assessed in microarray analysis of RNA isolated from four different cell lines of prostate cancer (LNCaP, PC3, DU145, 22Rv1) compared with control cell line of prostate cancer (PrEc). The red color depicts high and green color showed a lower level of expression at p value <0.01.</p> <p><strong>Figure S2A.</strong> Drug resistance by drug efflux. The internetworking relationship with miRNAs and plasma membrane protein P-glycoprotein (Pgp-plasma membrane protein). The miRNA-130a and miR-181a are downregulated in this pathway (green color) and linked with Pg and BCRP (breast cancer resistant protein). miR-133a and miR379 are involved in regulating the expression of MRP2. While miR-298, miR27a, miR331-5p and miR-130a are involved in regulating the expression of poly-glycoprotein (P-gp).</p> <p><strong>Figure S2B.</strong> Epithelial mesenchymal transition pathway. The miR-200b was downregulated during early-stage prostate cancer and was involved in inhibiting Jagged-2 (JAG2), one of the NOTCH ligands.</p> <p><strong>Figure S2C.</strong> Adipogenesis pathway. The expression of miR-326 was upregulated during the metastatic stage of prostate cancer, (red color) and involved in regulating the expression of CCAT/enhancer binding protein β (C/EBPβ), directly linked with the nuclear hormone receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ).</p> <p><strong>Figure S2D.</strong> Bone metamorphosis signaling pathway. The expression of miR-140, miR-145, and miR-155 was upregulated, along with miR-140 and miR-145 were associated with modulation of gene SOX9, and miR-155 was involved in regulating the gene FOXO3A.</p> <p><strong>Figure S2E.</strong> Th1 pathway. In this pathway, the expression of miR-146a showed a higher level of expression (red color) and modulated the expression of NF-κB signaling.</p> <p><strong>Figure S2F.</strong> Th1 and Th2 pathway. In this pathway, the expression of miR-146a showed a lower level of expression (green color) and may modulate the expression of NF-κB signaling.</p> <p><strong>Table S1.</strong> List of differentially expressed miRNAs derived from LNCaP cells lines statistically significant as P < 0.001.</p> <p><strong>Table S2.</strong> List of differentially expressed miRNAs derived from PC3 cells lines statistically significant as P < 0.001.</p> <p><strong>Table S3.</strong> List of differentially expressed miRNAs derived from DU145 cells lines statistically significant as P < 0.001.</p> <p><strong>Table S4.</strong> List of differentially expressed miRNAs derived from 22Rv1 cells lines statistically significant as P < 0.001.</p>
Data from: Integrating pheromonal and spatial information in the amygdalo-hippocampal network. Villafranca-Faus et al. 2021
<p>The local field potential (LFP) of the dorsal hippocampus (CA1) and cortical amygdala (PMCo) of mice, under head-fix recording and inmersed on a virtual environtmernt.</p> <p><strong>Paper Abstract</strong>: <br> Vomeronasal information is critical in mice for territorial behavior. Consequently, learning the territorial spatial structure should incorporate the vomeronasal signals indicating individual identity into the hippocampal cognitive map. In this work we show in mice that navigating a virtual environment induces synchronic activity, with causality in both directionalities, between the vomeronasal amygdala and the dorsal CA1 of the hippocampus in the theta frequency range. The detection of urine stimuli induces synaptic plasticity in the vomeronasal pathway and the dorsal hippocampus, even in animals with experimentally induced anosmia. In the dorsal hippocampus, this plasticity is associated with the overexpression of pAKT and pGSK3β. An amygdalo-entorhino-hippocampal circuit likely underlies this effect of pheromonal information on hippocampal learning. This circuit likely constitutes the neural substrate of territorial behavior in mice, and it allows the integration of social and spatial information.</p>
Data for: Induction of C4 genes during de-etiolation of Gynandropsis gynandra evolved through changes in cis allowing integration into ancestral C3 gene regulatory networks
<p>C4 photosynthesis has evolved repeatedly and in doing so repurposed existing enzymes to drive a carbon pump that limits the oxygenation reaction of RuBisCO. C4 proteins accumulate to levels matching those of the photosynthetic apparatus, and to allow this gene expression must be modified over evolutionary time. To better understand this rewiring of gene expression we undertook RNA-SEQ and <span>DNaseI</span>-SEQ on de-etiolating seedlings of C4 <em>Gynandropsis gynandra</em> which is evolutionarily proximate to C3 <em>A. thaliana</em>. Changes in chloroplast ultrastructure and C4 gene expression in <em>G. gynandra</em> were coordinated and rapid. C3 and C4 photosynthesis genes showed similar induction patterns, but C4 genes from <em>G. gynandra</em> were more strongly induced than orthologs from <em>A. thaliana</em>. The cistrome of <em>G. gynandra</em> was enriched in TGA, TCP and homeodomain binding sites. Furthermore,<em> in vivo</em> binding data in <em>G. gynandra</em> highlighted TGA and homeodomain as well as light responsive elements such as G- and I-box motifs as being associated with the rapid increase in transcripts derived from C4 genes. Although promoters of <em>PPDK</em> and <em>ASP1</em> from <em>G. gynandra</em> contained distinct light responsive elements, promoters from both <em>A. thaliana</em> and <em>G. gynandra</em> allowed high expression. Deletion analysis of the <em>Ppa6</em> gene from <em>G. gynandra</em> showed that regions containing G- and I-boxes were necessary for high expression. The data support a model in which accumulation of transcripts derived from C4 genes in leaves of <em>G. gynandra</em> is enhanced compared with homologs in <em>A. thaliana</em> because a variety of modifications in <em>cis</em> allowed integration into ancestral transcriptional networks.</p>
Unsupervised neural network for single cell Multi-omics INTegration (UMINT): An application to health and disease
<p>This dataset repository corresponds to the project Unsupervised neural network for single cell Multi-omics INTegration (UMINT): An application to health and disease.</p>
Supplementary data of article Integrating Data-Driven and Hydraulic Modelling with Acoustic Sensor Information for Improved Leak Location in Water Distribution Networks
<p>This dataset was generated within the research thesis of Axel Hutomo, under the supervision of Leonardo Alfonso and Ioana Popescu at IHE Delft, and it is published as supplementary data for the article <em>Integrating Data-Driven and Hydraulic Modelling with Acoustic Sensor Information for Improved Leak Location in Water Distribution Networks, </em>currently under review. </p> <p>The Excel sheet provides information about the datasets produced to integrate acoustic sensor data and hydraulic model output data, to be used by the Machine Learning model. The acoustic sensor data were obtained by extracting several features in time and frequency domains from each audio file coming from acoustic sensors, whereas hydraulic model data was obtained by modelling these leaks using a pressure-independent analysis.</p> <p>The Python code shows the building of the ANN for leakage modelling prediction, integrating the two datasets above, for different leak rates.</p>
Data for: Induction of C4 genes during de-etiolation of Gynandropsis gynandra evolved through changes in cis allowing integration into ancestral C3 gene regulatory networks
Open the record for dataset details and reuse information.
COVID-CDR: An integrative resource for network-based investigation of COVID-19 combinatorial drug repositioning and mechanism of action
<p>Repurposing of the existing medications has become the mainstream focus of anti-COVID-19 drug discovery as it offers rapid and cost-effective solutions for therapeutic development. However, a great effort is still required to enhance the efficacy of repurposing therapeutic options through combination therapy, in which promising drugs with varying mechanisms of action are administered together. Nonetheless, our ability to identify and validate effective combinations is limited due to the vast number of possible drug pairs. Yet, there is no <span>available resource that</span> <span>can systematically guide to identify or choose the effective individual drugs or best possible synergistic drug combinations for the treatment of SARS-CoV</span>-<span>2 infection.</span> To address this resource gap<span>, we </span>developed <span>a web-based platform that displays the network-based mechanism of action of drug combinations, thus simultaneously </span>providing <span>a visual of the cellular interactome involved in modes of action of the chosen drugs. The platform allows the freedom to </span>select <span>two or more drug combinations and provides the options to investigate the network-based efficacy of drug combinations and understand the similarity score, primary indications, and pairwise synergistic scores on different cell-lines. In a nutshell, the platform (accessible via </span><a href="http://vafaeelab.com/COVID19_repositioning.html"><span>http://vafaeelab.com/COVID19_repositioning.html</span></a><span>) is the first of its type, which provides a systematic approach for pre-clinical investigation of combination therapy for treating COVID-19 at the fingertips of the clinicians or researchers.</span></p>
Dataset of alternative process plan networks for dynamic integrated process planning and scheduling
<p>This dataset includes 3D models of representative manufacturing parts (jobs) as well as their features. For each of the manufacturing part, alternative process plan networks are given containing alternative machine tools, cutting tools, Tool Access Directions (TADs) and manufacturing times. The dataset also includes a detailed technical specification for all parts and calculated manufacturing times for all operations based on given alternative manufacturing resources.</p>
Supplementary materials for "Integration of public DNA methylation and expression networks via eQTMs improves prediction of functional gene–gene associations"
<p>This repository contained supplementary materials in the study named: "<strong>Integration of public DNA methylation and expression networks via eQTMs improves prediction of functional gene–gene associations.</strong>"</p> <p>For extracting all files from the downloaded tar.gz file, the following commanda could be used:</p> <pre><code>tar -xf supplementary_materials.tar.gz </code></pre> <p>The supplementary_materials/data diretcory contains the following sections:</p> <p></p> <ol> <li>eqtm_predictions: This contains the training and testing datasets for the eQTM prediction procedures</li> <li>public_methylation_data_and_pca: This contains the harmonized public DNA methylation dataset and its first 100 PCA components</li> <li>cca_data: This contains the CCA components for the public DNA methylation and gene expression datasets for the negative eQTMs, and the input datasets for the functional gene pair prediction analylsis.</li> <li>gene_enrichment_results_for_cca: This contains the gene enrichment results for the CCA components for negative and positive eQTMs</li> </ol> <p>The supplementary_materials/model directory contains the following sections:</p> <ol> <li>disease_tissue_predictions: This contains the models trained for tissue prediction and disease prediction based on the PCA components from the public DNA methylation data</li> <li>eqtm_predictions: This contains models trained for eQTM prediction</li> <li>cca_transformations: This contains CCA transformation models and models for STRING gene pair predictions </li> </ol>
Data from: Applicability of artificial neural networks to integrate socio-technical drivers of buildings recovery following extreme wind events
<p>The data provided and the associated MATLAB code were used to build an Artificial Neural Network Model to capture the reconstruction (recovery) of various buildings subjected to tornado events in the State of Missouri. The ANN model utilizes relevant tornado, societal demographic, and structural data to determine a building's resulting damage state from an extreme wind event and the subsequent recovery time. Abstract for the publication is as follows:</p> <p>In a companion article, previously published in Royal Society Open Science, the authors used Graph Theory to evaluate artificial neural network models for potential social and building variables interactions contributing to building wind damage. The results promisingly highlighted the importance of social variables in modeling damage as opposed to the traditional approach of solely considering physical characteristics of a building. Within this update article, the same methods are used to evaluate two different artificial neural networks for modelling building repair and/or rebuild (recovery) time. In contrast to the damage models, the recovery models consider (A) primarily social variables and then (B) introduce structural variables. These two models are then evaluated using centrality and shortest path concepts of Graph Theory as well as validated against data from the 2011 Joplin Tornado. The results of this analysis do not show the same distinctions as were found in the analysis of the damage models from the companion article. The overarching lack of discernible and consistent differences in the recovery models suggests that social variables that drive damage are not necessarily contributions to recovery. The differences also serve to reinforce that machine learning methods are best used when the contributing variables are already well understood.</p>
Integrating nocturnal and diurnal interactions in a Neotropical pollination network
<p><span>Plants establish pollination interactions with different groups of animals, including nocturnal ones that establish interactions with economically valuable and culturally important crops, as well as wild plants of conservation concern. Despite the considerable number of studies addressing the structure and dynamic of pollination networks, nocturnal interactions have been relatively overlooked. Using a multilayer network approach and considering diurnal and nocturnal interactions, we aimed to understand how interactions at different periods of the day are integrated and contribute to the network structural pattern. We also aimed to highlight how multilayer networks may give a more nuanced assessment of species importance across layers.</span></p> <p><span>We assembled a pollination network of an intensively studied Neotropical area by standardizing interaction data from 16 previous studies into a presence/absence (binary) network. Then we used a multilayer network approach to evaluate the network modularity and plant </span><span>species'</span><span> roles in these different temporal layers. Plants were classified as nocturnal or diurnal according to the onset of floral opening and pollinators were classified according to their foraging period. </span></p> <p><span>The network consisted of 178 pollinator species and 158 plant species, with 870 links. Among plant species, 135 species have diurnal floral opening while 23 species are nocturnal. The multilayer network was significantly modular, and these modules differed in the composition of pollinator groups (e.g., hawk moths, bats, bees, hummingbirds), as well as of diurnal and nocturnal plants. We show that diurnal and nocturnal interactions are organized into interconnected modules in the multilayer network. Nocturnal plants had higher values of versatility and multidegree than diurnal plants, due to their role in connecting the two temporal layers.</span></p> <p><span><em>Synthesis</em></span><span>. Our study highlights the importance of integrating different pollination systems to understand the importance of distinct components that structure pollination networks. We also illustrate the value of tapping into existing information, </span><span>particularly species interaction data, </span><span>from well studied biodiversity hotspot areas, to gain a better understanding of how communities are structured. Finally, despite the relative scarcity of nocturnal pollination network studies, we showed nocturnal plants, which often make complementary use of diurnal pollinators, to be important in connecting the temporal layers.</span></p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.