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Dataset results
259 results for “neuronal development”
Neurothreads: development of supportive carriers for mature dopaminergic neuron differentiation and implantation
<p>Raw data for the publication:</p> <p><strong>Neurothreads: development of supportive carriers for mature dopaminergic neuron differentiation and implantation</strong></p>
The Human Developing Cerebral Cortex Is Characterized by an Elevated De Novo Expression of Long Noncoding RNAs in Excitatory Neurons
<p>This project contains the annotated transcriptomes in GTF format used in the manuscript "The Human Developing Cerebral Cortex Is Characterized by an Elevated De Novo Expression of Long Noncoding RNAs in Excitatory Neurons" DOI: <a href="https://doi.org/10.1093/molbev/msae123">https://doi.org/10.1093/molbev/msae123</a></p>
Data from: Developmental Dieldrin exposure alters DNA methylation at genes related to dopaminergic neuron development and Parkinson's disease in mouse midbrain
Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Despite previous work showing a link between developmental dieldrin exposure and increased neuronal susceptibility to MPTP toxicity in male C57BL/6 mice, the mechanism mediating this effect has not been identified. Here, we tested the hypothesis that developmental exposure to dieldrin increases neuronal susceptibility via genome-wide changes in DNA methylation. Starting at 8 weeks of age and prior to mating, female C57BL/6 mice were exposed to 0.3 mg/kg dieldrin by feeding (every 3 days) throughout breeding, gestation, and lactation. At 12 weeks of age, pups were sacrificed and ventral mesencephalon, containing primarily substantia nigra, were microdissected. DNA was isolated and dieldrin-related changes in DNA methylation were assessed via reduced representation bisulfite sequencing (RRBS). We identified significant, sex-specific differentially methylated CpGs (DMCs) and regions (DMRs) by developmental dieldrin exposure (FDRNr4a2 and Lmx1b genes, which are involved in dopaminergic neuron development and maintenance. Developmental dieldrin exposure had distinct effects on the male and female epigenome. Together, our data suggest that developmental dieldrin exposure establishes sex-specific poised epigenetic states early in life. These poised epigenomes may mediate sensitivity to subsequent toxic stimuli and contribute to the development of late-life neurodegenerative disease, including PD.
Multielectrode array recordings of spontaneous activity in developing neuronal cultures
<p>These data are to accompany the following paper:</p> <p>Charlesworth P, Morton A, Eglen SJ, Komiyama NH, Grant SGN (2015) Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns. Neuropharmacology</p> <p>Available at: http://dx.doi.org/10.1016/j.neuropharm.2015.07.027.</p> <p> </p> <p>For further details about the data, please see h<span>ttp://damtp.cam.ac.uk/user/sje30/papers/charlesworth2015_data.pdf</span></p>
Notch directs telencephalic development and neuron fate determination by regulating miRNA levels
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Developmental dieldrin exposure alters DNA methylation at genes related to dopaminergic neuron development and Parkinson’s disease in mouse midbrain
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Data for Chromatin compaction precedes apoptosis in developing neurons by Rose et al.
<p>Data for Chromatin compaction precedes apoptosis in developing neurons by Rose et al.</p>
Dataset related to article "Neonicotinoid pesticides affect developing neurons in experi-mental mouse models and in human induced pluripotent stem cell (iPSC)-derived neural cultures and organoids"
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Neonicotinoid pesticides affect developing neurons in experi-mental mouse models and in human induced pluripotent stem cell (iPSC)-derived neural cultures and organoids
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Data from: Multivariate analysis of electrophysiological diversity of Xenopus visual neurons during development and plasticity
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Data from: Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains
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Data from: Development of resurgent and persistent sodium currents in mesencephalic trigeminal neurons
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A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development [RNA-seq]
GEO Series GSE221764. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Single Cell RNA-seq Study of Midbrain and Dopaminergic Neuron Development in Mouse, Human, and Stem Cells
GEO Series GSE76381. Homo sapiens; Mus musculus. 6179 samples. Type: Expression profiling by high throughput sequencing.
Spatiotemporal molecular and cellular dynamics of intratelencephalic neurons in mouse prefrontal cortex during postnatal development
GEO Series GSE298260. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons
GEO Series GSE85705. Mus musculus. 28 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain
GEO Series GSE268378. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Fragile X Syndrome Patient–Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes
GEO Series GSE202895. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Single-Nucleus RNA Sequencing of Developing and Mature Superior Colliculus Identifies Neuronal Diversity and Candidate Mediators of Circuit Assembly
GEO Series GSE224407. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Single-nucleus sequencing data from developing and adult mouse olivocochlear neurons
GEO Series GSE214027. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.