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4 results for “non-additive genetic effects”
Using inbreeding to test the contribution of non-additive genetic effects to additive genetic variance: A case study in Drosophila serrata
<p>Additive genetic variance, <em>V<sub>A</sub></em>, is the key parameter for predicting adaptive and neutral phenotypic evolution. Changes in demography (e.g., increased close-relative inbreeding) can alter <em>V<sub>A</sub></em>, but how depends on the, typically unknown, gene action and allele frequencies across many loci. For example, <em>V<sub>A</sub></em> increases proportionally with the inbreeding coefficient when allelic effects are additive, but larger (or smaller) increases can occur when allele frequencies are unequal at causal loci with dominance effects. Here, we describe an experimental approach to assess the potential for rare, recessive alleles to inflate <em>V<sub>A</sub></em> under inbreeding. Applying a powerful paired pedigree design in <em>Drosophila serrata</em>, we measured 11 wing traits on half-sibling families bred via either random or sibling mating, differing only in homozygosity (not allele frequency). Despite close inbreeding and substantial power to detect small <em>V<sub>A</sub></em>, we detected no deviation from the expected additive effect of inbreeding on genetic (co)variances. Our results suggest the average dominance coefficient is very small relative to the additive effect, or that allele frequencies are relatively equal at loci affecting wing traits. We outline the further opportunities for this paired pedigree approach to reveal the characteristics of <em>V<sub>A</sub></em>, providing insight into historical selection and future evolutionary potential.</p>
Non-additive genetic effects induce novel phenotypic distributions in male mating traits of F1 hybrids
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Using inbreeding to test the contribution of non-additive genetic effects to additive genetic variance: A case study in Drosophila serrata
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Genomic prediction with non-additive effects in beef cattle: Stability of variance component and genetic effect estimates against population size
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.