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6 results for “non-genetic inheritance”
Non-genetic inheritance restraint of cell-to-cell variation
<p>Data files.</p>
Data from: (In)exhaustible suppliers for evolution? Epistatic selection tunes the adaptive potential of non-genetic inheritance
Non-genetic inheritance media, from methyl-accepting cytosines to culture, tend to 'mutate' more frequently than DNA sequences. Whether or not this makes them inexhaustible suppliers for adaptive evolution will depend on the effect of non-genetic mutations (hereafter epimutations) on fitness-related traits. Here we investigate how the magnitude of these effects might themselves evolve, specifically whether natural selection may set boundaries to the adaptive potential of non-genetic inheritance media due to their higher mutability. In our model, the genetic and epigenetic contributions to a non-neutral phenotype are controlled by an epistatic modifier locus, which evolves under the combined effects of drift and selection. We show that a pure genetic control evolves when the environment is stable, provided that the population is large, such that the phenotype becomes robust to frequent epimutations. When the environment fluctuates, however, selection on the modifier locus also fluctuates and can overall produce a large non-genetic contribution to the phenotype, especially when the epimutation rate matches the rate of environmental variation. We further show that selection on the modifier locus is generally insensitive to recombination, meaning it is mostly direct, i.e. not relying on subsequent effects in future generations. These results suggest that unstable inheritance media might significantly contribute to fitness variation of traits subject to highly variable selective pressures, but little to traits responding to scarcely variable aspects of the environment. More generally, our study demonstrates that the rate of mutation and the adaptive potential of any inheritance media should not be seen as independent properties.
Data from: (In)exhaustible suppliers for evolution? Epistatic selection tunes the adaptive potential of non-genetic inheritance
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Data from: How differing modes of non-genetic inheritance affect population viability in fluctuating environments
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The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally
GEO Series GSE240797. Mus musculus. 208 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans
GEO Series GSE293020. Caenorhabditis elegans. 245 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.