Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
73
datasets available to search
ShareScore release 0.9.0
Dataset results
73 results for “non-obese”
Data from: Investigating the human and non-obese diabetic mouse MHC class II immunopeptidome using protein language modelling.
<p><strong>Background</strong>: Identifying peptides associated with the major histocompability complex class II (MHCII) is a central task in the evaluation of the immunoregulatory function of therapeutics and drug prototypes. MHCII-peptide presentation prediction has multiple biopharmaceutical applications, including the safety assessment of biologics and engineered derivatives in silico, or the fast progression of antigen-specific immunomodulatory drug discovery programs in immune disease and cancer. This has resulted in the collection of large–scale data sets on adaptive immune receptor antigenic responses and MHC-associated peptide proteomics. In parallel, recent deep learning algorithmic advances in natural language processing (NLP) and protein language modelling (PLM) have shown potential in leveraging large collections of sequence data and improve MHC presentation prediction. <strong>Methodology</strong>: We trained a compact transformer model (AEGIS) on human and mouse MHCII immunopeptidome data, including a preclinical murine model, and evaluated its performance on the peptide presentation prediction task. <strong>Data</strong>: The data and models used in AEGIS are contained in the uploaded tar files. <strong>Results</strong>: The transformer performs on par with existing deep learning algorithms and that combining datasets from multiple organisms increases model performance (see preprint). We trained variants of the model with and without MHCII information. In both alternatives, the inclusion of peptides presented by the I-Ag7 MHC class II molecule expressed by the non-obese diabetic (NOD) mice enabled the in silico prediction of presented peptides in a preclinical type 1 diabetes model organism, which has promising therapeutic applications.</p>
Snack Food Reinforcement in Obese and Non-obese Women
ClinicalTrials.gov study NCT00837694. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Gut microbiota in non-obese adolescent girls with polycystic ovary syndrome: effects of randomized treatments
<p class="Paragraph"><span><span><span><span><span><span><span><span><span><span><span><b>Context:</b> Women and obese adolescent girls with polycystic ovary syndrome (PCOS) have altered gut microbiota. </span></span></span></span></span></span></span></span></span></span></span></p> <p class="Paragraph"><span><span><span><span><span><span><span><span><span><span><span><b>Objective:</b> To study the gut microbiota composition of non-obese adolescent girls with PCOS and the effects of randomized pharmacological treatments.</span></span></span></span></span></span></span></span></span></span></span></p> <p class="Paragraph"><span><span><span><span><span><span><span><span><span><span><span><b>Design:</b> Randomized, open-label, single-center controlled trial. </span></span></span></span></span></span></span></span></span></span></span></p> <p class="Paragraph"><span><span><span><span><span><span><span><span><span><span><span><b>Settings:</b> Endocrinology Department, University Hospital. </span></span></span></span></span></span></span></span></span></span></span></p> <p class="Paragraph"><span><span><span><span><span><span><span><span><span><span><span><b>Participants: </b>30 girls with PCOS [age 15.8 years; body mass index (BMI) 25 kg/ m<sup>2</sup>] and 31 controls [age 15.9 years; BMI 22 kg/ m<sup>2</sup>]. </span></span></span></span></span></span></span></span></span></span></span></p> <p class="Paragraph"><span><span><span><span><span><span><span><span><span><span><span><b>Intervention:</b> PCOS girls were randomized to receive an oral contraceptive (OC, N= 15) or spironolactone-pioglitazone-metformin (SPIOMET, N= 15) for 1 year. </span></span></span></span></span></span></span></span></span></span></span></p> <p class="Paragraph"><span><span><span><span><span><span><span><span><span><span><span><b>Outcomes: </b>16S ribosomal subunit gene amplicon sequencing was used to describe and quantify microbial diversity and taxonomic profiles in stool samples from all subjects. Samples from 23 out of 30 girls with PCOS (OC, N= 11; SPIOMET, N= 12) were available for analysis post-treatment. Correlations between bacterial results and endocrine-metabolic variables were performed before and after randomized treatments. </span></span></span></span></span></span></span></span></span></span></span></p> <p class="Paragraph"><span><span><span><span><span><span><span><span><span><span><span><b>Results:</b> Girls with PCOS had decreased diversity alpha, altered microbiota pattern and taxonomic profile with more abundance of <i>Family XI</i> (<i>P</i>= 0.002), and less abundance of family <i>Prevotellaceae</i> (<i>P</i>= 0.0006) and the genus <i>Prevotella</i> (<i>P</i>= 0.0001) and <i>Senegalimassilia</i> (<i>P</i>< 0.0001), as compared to controls. <i>Family XI</i>abundance related positively to hepato-visceral fat (R= 0.453; <i>P</i>= 0.0003). SPIOMET treatment, but not OC, normalized the abundance of <i>Family XI</i>. <i>Prevotellaceae</i>, <i>Prevotella</i> and <i>Senegalimassilia</i> abundance remained unchanged after either treatment. </span></span></span></span></span></span></span></span></span></span></span></p> <p class="Paragraph"><span><span><span><span><span><span><span><span><span><span><span><b>Conclusion:</b> SPIOMET's spectrum of normalizing effects in non-obese girls with PCOS is herewith broadened as to include <i>Family XI</i> abundance in gut microbiota. </span></span></span></span></span></span></span></span></span></span></span></p>
Dataset of the study "Factor Structure, Validity, and Reliability of the STarT Back Screening Tool in Italian Obese and Non-obese Patients With Low Back Pain"
<p>Dataset of the study "Factor Structure, Validity, and Reliability of the STarT Back Screening Tool in Italian Obese and Non-obese Patients With Low Back Pain" published in Frontiers in Psychology 20 October 2021 12:740851, doi: 10.3389/fpsyg.2021.740851</p>
GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients
ClinicalTrials.gov study NCT05316935. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 1a/1b Study of CB4211 in Healthy Non-obese Subjects and Subjects With Nonalcoholic Fatty Liver Disease
ClinicalTrials.gov study NCT03998514. IPD Sharing: NO. Countries: 1. Publications: 1.
IR, Inflammatory and Cardiovascular Markers in PCOS Among Obese and Non-obese Women
ClinicalTrials.gov study NCT01989039. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Microarray Analysis of IFN-Induced Gene Expression in Obese and Non-Obese Patients With Chronic Hepatitis C
ClinicalTrials.gov study NCT00322179. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Postoperative SpO₂/FiO₂ in Obese and Non-Obese Patients: Role of STOP-BANG
ClinicalTrials.gov study NCT07188649. IPD Sharing: NO. Countries: 1. Publications: 1.
Contraception and Cervical and Breast Cancer Screening in Obese Versus Non-obese Women
ClinicalTrials.gov study NCT04357652. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Single Dose PK of IV Tedizolid Phosphate in Morbidly Obese and Non-Obese Adults
ClinicalTrials.gov study NCT02342418. IPD Sharing: NO. Countries: 0. Publications: 1.
Surgical Treatment of Non-obese Type 2 Diabetic Patients With Duodenal Exclusion
ClinicalTrials.gov study NCT00566358. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Comparison of Successful Spinal Needle Insertion Between Obese and Non-obese Pregnant Women
ClinicalTrials.gov study NCT03054233. IPD Sharing: UNDECIDED. Countries: 1. Publications: 16.
Monitoring During Different Intermittent Fasting Protocols in Non-Obese Adults
ClinicalTrials.gov study NCT04732130. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Repaglinide Versus Metformin Treatment in Non-Obese Patients With Type-2-Diabetes
ClinicalTrials.gov study NCT00118963. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Chiglitazar/Metformin in Non-obese Women With PCOS
ClinicalTrials.gov study NCT06125587. IPD Sharing: NO. Countries: 1. Publications: 1.
Brain Blood Flow and Lactate in Non-obese and Obese Subjects
ClinicalTrials.gov study NCT06791837. IPD Sharing: YES. Countries: 1. Publications: 3.
The Incidence of Difficult Intubation in Obese Versus Non-obese Patients
ClinicalTrials.gov study NCT03752593. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Gut microbiota in non-obese adolescent girls with polycystic ovary syndrome: effects of randomized treatments
Open the record for dataset details and reuse information.
Upper Airway Obstruction in Non-obese Patients With Snoring and Obstructive Sleep Apnea
ClinicalTrials.gov study NCT04324671. IPD Sharing: Not stated. Countries: 0. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.