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4 results for “novel object test”
Data for Radial arm maze tests and Novel object recognition test
<p class="MsoNormal"><strong><span>Background</span></strong></p> <p class="MsoNormal"><span>Aging population is rapidly expanding worldwide, and age-related cognitive impairments proves detrimental for achieving a better productive and quality of life. Lack of effective therapies for age-related cognitive impairment focuses attention on developing preventive strategies, such as nutritional interventions, cell therapies and environmental manipulations. The objective of present study was to explore the comparative benefits of potential memory-enhancing strategies like supplementation of choline and docosahexaenoic acid (DHA) or administration of conditioned media derived from human embryonic kidney stem cells (HEK-CM) or exposure to environmental enrichment (EE), that attenuates cognitive impairments in aging mice. </span></p> <p class="MsoNormal"><strong><span>Results</span></strong></p> <p class="MsoNormal"><span>Spatial memory and cognition were decreased in normal aging mice. Aged mice exposed to dietary Ch-DHA or HEK-CM showed significant enhancement in spatial learning tasks, memory and cognition compared to the same in age-matched NAC mice. Ch-DHA and HEK-CM treated mice committed significantly lesser reference memory errors and attained a higher percentage of correct choices in spatial learning and memory tasks. Moreover, on testing for cognition in</span><span> NORT,</span><span> significantly higher number of visits to the novel object was observed in Ch-DHA supplemented and HEK-CM administered aging mice whereas HEK-CM and EE mice groups showed significantly greater number of visits to familiar object, when compared to same in age-matched NAC and HI-HEKCM groups respectively</span><span>.</span><span> </span></p> <p class="MsoNormal"><strong><span>Conclusion</span></strong></p> <p class="MsoNormal"><span>Supplementation of Ch-DHA and HEK CM treatment strategies have a higher potential [~ 20-30%] for enhancing spatial learning, memory and cognition in normal aged mice, whereas exposure to enriched environment seems to enhance only their short term memory.</span></p>
Data for Radial arm maze tests and Novel object recognition test
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RNA-Seq data from cortex and hippocampus (post novel object recognition test) of rats in a vagus nerve stimulation study
GEO Series GSE134309. Rattus norvegicus. 15 samples. Type: Expression profiling by high throughput sequencing.
A Novel Objective Diagnostic Test for Otitis Media With Effusion
ClinicalTrials.gov study NCT02179541. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.