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233 results for “old age”
Age-related proteostatic imbalance exacerbates heart failure with preserved ejection fraction pathogenesis in old mice
<p>Heart failure with preserved ejection fraction (HFpEF) is a leading cause of hospitalization and death in the elderly. While aging strongly increases the incidence of HFpEF, the specific influences of aging on HFpEF at molecular and pathophysiological levels remain unclear. Here, we show that aged mice, when subjected to chronic metabolic and hypertensive stress (2-hit stress), develop an aggravated cardiometabolic HFpEF phenotype compared to younger counterparts. Aged HFpEF mice also display unique pathological characteristics reminiscent of those found in HFpEF patients. We demonstrate that age-related dysfunction in protein quality control (PQC) exacerbates proteostatic stress in HFpEF. Specifically, we demonstrate that increased protein synthesis induced by 2-hit stress combines with age-related impairment in protein degradation in aged HFpEF hearts, culminating in the accumulation of protein aggregates. These findings underscore the importance of incorporating aging into preclinical HFpEF models and support the therapeutic potentials of targeting PQC mechanisms to ameliorate disease outcomes.</p> <p>The deposited data are lc-ms data acquired on the Thermo QEx-Plus system. For any questions, please contact mike kinter mike-kinter at omrf.org</p> <p>This upload contains the bulk of the LC-MS data. But, due to file sizes, and addition group of files can be found at doi 10.5281/zenodo.11094720</p>
Mothers of twins had higher old-age survival than mothers of singletons in Estonian 19th-century birth cohorts
<p><strong><span>Study question:</span></strong><span> Do the mothers of twins and singletons differ regarding post-partum and old-age mortality?</span></p> <p><span> </span><strong><span>Summary answer:</span></strong><span> M</span><span>others of twins had twice as high post-partum mortality as mothers of singletons; survival of twinners was higher than survival of the mothers of singletons after the 67<sup>th </sup>lifespan percentile.</span></p> <p><strong><span>What is known already:</span></strong><span> Twinning is typically associated with higher post-partum maternal mortality. The evidence about whether twinning incurs long-term survival costs of reproduction or is a trait pertinent to long-lived women is scarce and contradictory.</span></p> <p><strong><span>Study design, size, duration:</span></strong><span> The study is based on the data of the Estonian Family Register (operating from 1926-43) and involves 5 565 mothers of twins and 119 613 mothers of singletons born between 1850-99. The subset for comparing maternal lifespans included 1 703 – 1 884 mothers of twins and </span><span>19 747 </span><span>– 36 690 mothers of singletons.</span></p> <p><strong><span>Participants/materials, setting, methods:</span></strong><span> Post-partum maternal mortality was analysed in the whole sample (including mothers of a single child) by logistic regression. Most of the analyses were performed in samples where each mother of twins was matched against mothers of singletons based on parity, urban versus rural origin, whether their lifespan was known, date of birth and age at first birth. Quantile regression was used to analyse age-dependent variations in maternal mortality rates. Lifespans were compared in linear mixed models. All models were adjusted for relevant biodemographic covariates.</span></p> <p><strong><span>Main results and the role of chance:</span></strong><span> The twinning rate in the whole sample was 4.4%. During the year after giving birth, maternal mortality for multiple gestations was 0.75% (17/2 273) and 0.37% (</span><span>449</span><span>/</span><span>122 750)</span><span> for single gestations (OR = 2.05, 95% CI = 1.21 – 3.23). The association between twinning and post-natal maternal mortality remained significant in a model controlling for parity and age of first and last birth. The life spans of the mothers of twins and singletons did not differ in matched samples. Past the 67<sup>th</sup> lifespan percentile, the odds of survival were significantly higher for mothers of twins than mothers of singletons, as indicated by non-overlapping 95% confidence intervals.</span></p> <p><strong><span>Limitations, reasons for caution: </span></strong><span>Relatively low number of individuals (22 802) with known age at death due to discontinuation of the register after 1943.</span></p>
Рис. 4. Поперечные срезы фаΛанг паΛьцев особей Bufo sachalinensis максимаΛьного возраста: A — шестиΛетний самец (L = 69.0 мм); B — семиΛетняя самка (L = 90.6 мм) Fig. 4. Cross-section image of phalanges of Bufo sachalinensis individuals of maximum age: A — six year old male (SVL = 69.0 mm); B — seven year old female (SVL = 90.6 mm) in Age structure and sexual dimorphism of the Far Eastern toad, Bufo sachalinensis Nikolsky, 1905 in the Ussurisky Nature Reserve
Рис. 4. Поперечные срезы фаΛанг паΛьцев особей Bufo sachalinensis максимаΛьного возраста: A — шестиΛетний самец (L = 69.0 мм); B — семиΛетняя самка (L = 90.6 мм) Fig. 4. Cross-section image of phalanges of Bufo sachalinensis individuals of maximum age: A — six year old male (SVL = 69.0 mm); B — seven year old female (SVL = 90.6 mm)
BRAIN Journal-Electrophysiological Neuroimaging using sLORETA Comparing 100 Schizophrenia Patients to 48 Patients with Major Depression -Figure 4. Histogram age distributions of the 100 Schizophrenia patients illustrating clusters of patients at 20, 30, 40, and 50 years old.
<p>The figure below is a histogram distribution of the ages of one hundred Schizophrenia<br> patients in this study. There appears to be a cyclical peak every ten-years cycles at 20, 30, 40, and<br> 50-year-old patients. This may suggest a recent finding that CD8 T cells, which play a pivotal role<br> in mediating long-term immunity to Toxoplasma, are down-regulated in schizophrenia patients<br> (Bhadra et al., 2013). Based on the aforementioned statements, a vaccine for Toxoplasmosis may be<br> difficult to achieve, but the treatment and screening possibilities in patients with psychosis are<br> available today.</p>
Old stone sculpture, midle ages.
Stone sculpture found near the St. Olav's Church in Avaldsnes, Rogaland - Norway in 1922. Decorative part of a stone building, either the church or the adjacent royal hall. The sculpture depicts a mans head with locks of hair. Made of soap stone but has become heavily worn during the course of time. Museums ID: S11724 Source: Objaverse 1.0 / Sketchfab
Beneficial cumulative effects of old parental age on offspring fitness
<p>Old parental age is commonly associated with negative effects on offspring life-history traits. Such parental senescence effects are predicted to have a cumulative detrimental effect over successive generations. However, old parents may benefit from producing higher quality offspring when these compete for seasonal resources. Thus, old parents may choose to increase investment in their offspring, thereby producing fewer but larger and more competitive progeny. We show that Caenorhabditis elegans hermaphrodites increase parental investment with advancing age, resulting in fitter offspring who reach their reproductive peak earlier. Remarkably, these effects increased over six successive generations of breeding from old parents and were subsequently reversed following a single generation of breeding from a young parent. Our findings support the hypothesis that offspring of old parents receive more resources and convert them into increasingly faster life-histories. These results contradict the theory that old parents transfer a cumulative detrimental "ageing factor" to their offspring.</p>
Data from: Validation of Quality-of-Life assessment tool for Ethiopian old age people
<p><strong>Background</strong>: Reliable quality of life assessment is critical for identifying health issues, evaluating health interventions, and establishing the best health policies and care packages. The World Health Organization Quality of Life-Old Module is a tool for assessing the subjective quality of life in old age people. It's validated and available in more than 20 languages, except Amharic. Hence, this study was intended to translate it into Amharic language and validate it among old age people in Ethiopia.</p> <p><strong>Methods</strong>: A cross-sectional study was conducted among 180 community-dwelling old age people in Ethiopia, from January 16 to March 13, 2021. Psychometric validation was achieved through Cronbach's alpha of the internal consistency reliability test, and construct validity from confirmatory factor analysis.</p> <p><strong>Results</strong>: The study participants aged from 60 to 90 years old with a mean age of 69.44. Females made up 61.7% of the population, and 40% of them could not read and write. The results showed a relatively low level of quality of life, with the total transformed score of 58.58 ± 23.15. The Amharic version of the World Health Organization Quality of Life-Old Module showed a Cronbach's Alpha value of 0.96 and corrected item-total correlations of more than 0.74. Confirmatory factor analysis confirmed the six-factor model with a chi-square (X2) of 341.98 with a p-value less than 0.001. The comparative fit index (CFI) was 0.98, Tucker-Lewis's index (TCL) was 0.97, and the root mean square error of approximation (RMSEA) was 0.046.</p> <p><strong>Conclusion</strong>: The Amharic version of the World Health Organization Quality of Life-Old Module indicated good internal consistency reliability and construct validity. The tool can be utilized to provide care to Ethiopian community-dwelling old age people.</p>
Three dimensional reconstruction of an existing age-old wooden shingle roof
<p>This dataset provides a complete and thorough three-dimensional reconstruction of an age-old shingled roof located in Rossinière, Switzerland (<a href="https://www.google.com/maps/dir//46.468247,7.059739/@46.4670828,7.012801,12z/data=!4m2!4m1!3e0">46.46837286488975, 7.059749511857417</a>), which provides reliable documentation to archive this valuable type of architecture.</p> <p>This dataset was obtained using a 3D Farco Focus scanner and the point clouds were processed using FaroScene software.</p> <p>This research was funded by the National Centres of Competence in Research (<a href="https://www.snf.ch/en/FJBJ8XGQ1tjG8J8w/funding/programmes/national-centres-of-competence-in-research-nccr">NCCRs</a>) and EPFL.</p>
Efficacy and Safety of Bumetanide Oral Liquid Formulation in Children Aged From 2 to Less Than 7 Years Old With Autism Spectrum Disorder.
ClinicalTrials.gov study NCT03715153. IPD Sharing: YES. Countries: 12. Publications: 2.
Postmarketing Surveillance Study for Quadrivalent Influenza Vaccine (VaxigripTetra Inj.) in Subjects Aged 3 Years Old and Above
ClinicalTrials.gov study NCT05406180. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Test if the Vaccine is Working Well in Chronic Obstructive Pulmonary Disease (COPD) Patients Aged 40 to 80 Years Old to Reduce Episodes of Worsening Symptoms and to Gather Further Informati
ClinicalTrials.gov study NCT03281876. IPD Sharing: YES. Countries: 8. Publications: 2.
Immunogenicity and Safety of PrepandrixTM in Korean Subjects Aged 18 to 60 Years Old
ClinicalTrials.gov study NCT01730378. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Safety and Efficacy Study of Beclomethasone Dipropionate Delivered Via Breath-Actuated Inhaler (BAI) or Metered-Dose Inhaler (MDI) in Participants Ages 4-11 Years Old With Persistent Asthma
ClinicalTrials.gov study NCT02040766. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Safety and Immunogenicity of Three Influenza Vaccines in Children Aged 4 Years Old to Less Than 18 Years Old
ClinicalTrials.gov study NCT01992107. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men
ClinicalTrials.gov study NCT06613542. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Meningococcal B Recombinant Vaccine When Administered Concomitantly With Routine Vaccines to Healthy Infants of 2 Months of Age and Olde
ClinicalTrials.gov study NCT02173704. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Test if a Third Dose of the Vaccine is Safe in Current and Former Smokers Aged 40 to 80 Years Old and to Gather Information on the Immune Response Following the Third Dose of the Vaccine
ClinicalTrials.gov study NCT03443427. IPD Sharing: YES. Countries: 3. Publications: 1.
Study to Evaluate Safety and Efficacy of Dapagliflozin and Saxagliptin in Patients With Type 2 Diabetes Mellitus (T2DM) Aged 10 to Below 18 Years Old
ClinicalTrials.gov study NCT03199053. IPD Sharing: YES. Countries: 23. Publications: 1.
Evaluation of Safety,Pharmacokinetics and Efficacy of CAZ-AVI With Metronidazole in Children Aged 3 Months to 18 Years Old With Complicated Intra-abdominal Infections (cIAIs).
ClinicalTrials.gov study NCT02475733. IPD Sharing: Not stated. Countries: 10. Publications: 2.
A Study to Investigate the Safety and Efficacy of Lacosamide Added to the Patients Current Therapy in Patients Aged 1 Month to Less Than 18 Years Old With Epilepsy Syndromes Associated With Generalize
ClinicalTrials.gov study NCT01969851. IPD Sharing: Not stated. Countries: 5. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.