Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
47
datasets available to search
ShareScore release 0.9.0
Dataset results
47 results for “oligodendrocyte precursor cell”
Xiao et al, Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling [Dataset]
<p>Raw data from the behavior and imaging experiments of Xiao et al., Nature Neuroscience 2022. For additional details about the acquisition of each part of the dataset, refer to the methods section of the paper. From this dataset, using the published code, all the figures relative to the imaging in the optic tectum can be generated and all the cumulative statistics for the behavioural assays run with Stytra recomputed.</p> <p> </p> <p><strong>Organisation of the dataset</strong></p> <p>This dataset is organised in the following subdirectories:<br> - <em>freely_swimming</em>: contains the data for the freely swimming experiments quantifying motor activity in the various ablated groups. It contains subfolders of groups, each of which contains the Stytra raw data directories for all fish of that group. Refer to `Stytra` and `bouter` documentation for further details about the files.<br> - <em>OMR</em>: contains the data for the quantification of OMR reflex across different spatial frequencies. It contains subfolders for the control and ablated group, each of which contains the Stytra raw data directories for all fish of that group.<br> - <em>receptive_field_imaging</em>: contains the imaging data for the receptive field estimation. Subfolders contains, for each individual fish (both ablated and controls are pooled in the same directory):<br> - stytra raw output from the experiment<br> - data_from_suite2p_unfiltered.h5: `flammkuchen`-loadable `.h5` file that contains the raw fluorescent trace<br> - anatomy.mask: `flammkuchen`-loadable mask file saved by the `pypra` tool that was used for segmenting the tectum, delimiting the region of the tectum<br> The folder contains an additional file, `manual_alignment_offsets.h5`, where the offsets of the manual morphing across fish were saved.</p>
Data from: Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination
Myelin abnormalities are increasingly being recognized as an important component of a number of neurologic developmental disorders. The integration of many signaling pathways and cell types are critical for correct myelinogenesis. The PI3-K and mechanistic target of rapamycin (mTOR) pathways have been found to play key roles. mTOR is found within two distinct complexes, mTORC1 and mTORC2. mTORC1 activity has been shown to play a major role during myelination, while the role of mTORC2 is not yet well understood. To determine the role of mTORC2 signaling in myelinogenesis, we generated a mouse lacking the critical mTORC2 component Rictor in oligodendrocyte precursors (OPCs). Targeted deletion of Rictor in these cells decreases and delays the expression of myelin related proteins and reduces the size of cerebral white matter tracts. This is developmentally manifest as a transient reduction in myelinated axon density and g-ratio. OPC cell number is reduced at birth without detectable change in proliferation with proportional reductions in mature oligodendrocyte number at P15. The total number of oligodendrocytes as well as extent of myelination, does improve over time. Adult conditional knock-out (CKO) animals do not demonstrate a behavioral phenotype likely due in part to preserved axonal conduction velocities. These data support and extend prior studies demonstrating an important but transient contribution of mTORC2 signaling to myelin development.
Data from: Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination
Open the record for dataset details and reuse information.
Single-cell Sequencing Reveals Brain/Spinal Cord Oligodendrocyte Precursor Heterogeneity and Requirement for mTOR in Cholesterol Biosynthesis and Myelin Maintenance
GEO Series GSE190859. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis for mRNA expression difference between male and female cultured oligodendrocyte precursor cells
GEO Series GSE135709. Rattus norvegicus. 8 samples. Type: Expression profiling by high throughput sequencing.
After demyelination in the adult CNS, oligodendrocyte precursor cells revert to an immature mRNA profile and express immune cues favoring their migration
GEO Series GSE48872. Mus musculus. 18 samples. Type: Expression profiling by array.
A Cellular Atlas of the Down Syndrome Brain Identifies Accelerated Oligodendrocyte Precursor Cell Senescence
GEO Series GSE225554. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Gene expression analysis after GPR17 silencing in oligodendrocyte precursor cells (OPCs)
GEO Series GSE208409. Rattus norvegicus. 4 samples. Type: Expression profiling by array.
Single cell approaches define two mammalian oligodendrocyte precursor cell populations and their evolution over developmental time [scRNA-seq]
GEO Series GSE255405. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Reactive human iPSC astrocytes suppress oligodendrocyte precursor cell differentiation
GEO Series GSE196575. Homo sapiens. 46 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis for mRNA expression change in alpha-synclein fibril-treated cultured oligodendrocyte precursor cells
GEO Series GSE107582. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of knockdown of Secisbp2l in primary oligodendrocyte precursor cells
GEO Series GSE228245. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Oligodendrocyte precursor cells facilitate neuronal lysosome release
GEO Series GSE285995. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Functionally distinct subgroups of Oligodendrocyte precursor cells integrate neural activity and execute myelin formation
GEO Series GSE132166. Danio rerio. 1 samples. Type: Expression profiling by high throughput sequencing.
Primary cilia control Oligodendrocyte Precursor Cell proliferation in white matter injury via Hedgehog-independent CREB signaling.
GEO Series GSE243997. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis for mRNA expression change in oxygen/glucose deprivation-treated cultured oligodendrocyte precursor cells
GEO Series GSE114609. Rattus norvegicus. 8 samples. Type: Expression profiling by high throughput sequencing.
TNFR2 signaling regulates the immunomodulatory function of oligodendrocyte precursor cells
GEO Series GSE180604. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome outcome of oligodendrocyte precursor cells following VCAM1 knockdown
GEO Series GSE86862. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Single cell approaches define two mammalian oligodendrocyte precursor cell populations and their evolution over developmental time [scMultiome-seq]
GEO Series GSE255406. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Single cell approaches define two mammalian oligodendrocyte precursor cell populations and their evolution over developmental time [Xenium In Situ Gene Expression]
GEO Series GSE255407. Mus musculus. 3 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.