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8 results for “origin and migration”
Juvenile life history, migration, and habitat use of natural- versus hatchery-origin Chinook salmon
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Data from: Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells
<p class="CxSpFirst"><span>High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological malignancy. New evidence supports a hypothesis that HGSOC can originate from fallopian tube epithelium (FTE). It is unclear how genetic alterations and pathophysiological processes drive the progression of FTE tumor precursors into widespread HGSOCs. In this study, we uncovered that brain-derived neurotrophic factor (BDNF) in the follicular fluid stimulates the tropomyosin receptor kinase B (TrkB)-expressing FTE cells to promote their survival, migration, and attachment. Using <i>in vitro</i> and <i>in vivo</i> models, we further identified that the acquisition of common TP53 gain-of-function (GOF) mutations in FTE cells led to enhanced BDNF/TrkB signaling comparing to that of FTE cells with <i>TP53</i> loss-of-function (LOF) mutations. Different mutant p53 proteins can either increase TrkB transcription or enhance TrkB endocytic recycling. Our findings have demonstrated possible interplays between genetic alterations in FTE tumor precursors (i.e., p53 gain-of-function mutations) and pathophysiological processes (i.e., the release of follicular fluid upon ovulation) during the initiation of HGSOC from the fallopian tube. Our data revealed molecular events underlying the link between HGSOC tumorigenesis and ovulation, a physiological process that has been associated with risk factors of HGSOC. </span></p>
Data from: Variation in migration pattern, broodstock origin, and family productivity of coho salmon hatchery populations in British Columbia, Canada derived from parentage-based tagging.
In salmonid parentage-based tagging (PBT) applications, entire hatchery broodstocks are genotyped, and subsequently progeny can be non-lethally sampled and assigned back to their parents using parentage analysis, thus identifying their hatchery of origin and brood year (i.e. age). Inter- and intra-population variability in migration patterns, life history traits, and fishery contributions can be determined from PBT analysis of samples derived from both fisheries and escapements (portion of a salmon population that does not get caught in fisheries and returns to its natal river to spawn). In the current study of southern British Columbia coho salmon (Oncorhynchus kisutch) populations, PBT analysis provided novel information on intra-population heterogeneity among males in the total number of progeny identified in fisheries and escapements, the proportion of progeny sampled from fisheries versus escapement, the proportion of two-year old progeny (jacks) produced, and the within-season return time of progeny. Fishery recoveries of coho salmon revealed heterogeneity in migration patterns among and within populations, with recoveries from north and central coast fisheries distinguishing 'northern migrating' from 'resident' populations. In northern-migrating populations, the mean distance between fishery captures of sibs (brothers and sisters) was significantly less than the mean distance between non-sibs, indicating the possible presence of intra-population genetic heterogeneity for migration pattern. Variation among populations in productivity and within populations in fish catchability indicated that population selection and broodstock management can be implemented to optimize harvest benefits from hatcheries. Application of PBT provided valuable information for assessment and management of hatchery-origin coho salmon in British Columbia.
FIGURE1. Breeding, migrating and wintering distributions of Palearctic Anthus [rubescens] japonicus and Nearctic Anthus rubescens rubescens/alticola subspecies groups (from BirdLife International 2022; illustration @Andrew Birch). Circles indicate origins of sequenced individuals and triangles indicate origins of analysed recordings of calls. Localities outside of the usual range of the species complex (e.g., Ireland, Oman and Israel) are not figured here. in --Molecular--and--acoustic--evidence--support--the--species--status--of--Anthus rubescens rubescens and--Anthus [rubescens] japonicus--(Passeriformes:--Motacillidae)
FIGURE1. Breeding, migrating and wintering distributions of Palearctic Anthus [rubescens] japonicus and Nearctic Anthus rubescens rubescens/alticola subspecies groups (from BirdLife International 2022; illustration @Andrew Birch). Circles indicate origins of sequenced individuals and triangles indicate origins of analysed recordings of calls. Localities outside of the usual range of the species complex (e.g., Ireland, Oman and Israel) are not figured here.
Data from: Variation in migration pattern, broodstock origin, and family productivity of coho salmon hatchery populations in British Columbia, Canada derived from parentage-based tagging.
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Data from: Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells
Open the record for dataset details and reuse information.
Data from: Whole-genome sequencing of 128 camels across Asia reveals origin and migration of domestic Bactrian camels
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Genomic analyses reveal the influence of geographic origin, migration and hybridization on modern dog breed development
GEO Series GSE96736. Canis lupus familiaris. 158 samples. Type: Genome variation profiling by SNP array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.