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83 results for “orthostatic hypotension”
Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults, supplement methods & tables, STROND checklist
<p>Objective To test the hypothesis that orthostatic hypotension (OH) might cause cerebral hypoperfusion and injury, we examined the longitudinal relationship between orthostatic hypotension (OH) or orthostatic symptoms and incident neurologic outcomes in a community population of older adults. Methods Cardiovascular Health Study (CHS) participants (≥65yrs) without dementia or stroke had blood pressure (BP) measured after lying 20-minutes and after standing 3-minutes. Participants reported dizziness immediately upon standing and any dizziness in the past 2wks. OH was defined as a drop in standing systolic/diastolic BP ≥20/≥10mmHg. We determined the association between OH or dizziness with (1) MRI brain findings (ventricular size, white matter hyperintensities, brain infarcts) using linear or logistic regression, (2) cognitive function (baseline and over time) using generalized estimating equations, and (3) prospective adjudicated events (dementia, stroke, death) using Cox models. Models were adjusted for demographic characteristics and OH risk factors. We used multiple imputation to account for missing OH or dizziness (N=534). Results Prior to imputation, there were 5,007 participants (mean age 72.7±5.5yrs, 57.6% women, 10.9% black, 16% with OH). OH was modestly associated with death (HR=1.11; 95%CI:1.02,1.20), but not MRI findings, cognition, dementia, or stroke. In contrast, dizziness upon standing was associated with lower baseline cognition (β=-1.20;-1.94,-0.47), incident dementia (HR=1.32;1.04,1.62), incident stroke (HR=1.22;1.06,1.41), and death (HR=1.13; 1.06,1.21). Similarly, dizziness over the past two weeks was associated with higher white matter grade (β=0.16;0.03,0.30), brain infarcts (OR=1.31;1.06,1.63), lower baseline cognition (β=-1.18;-2.01,-0.34), and death (HR=1.13;1.04,1.22). Conclusions Dizziness was more consistently associated with neurologic outcomes than OH 3-minutes after standing. Delayed OH assessments may miss pathologic information related to cerebral injury.</p>
Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension
ClinicalTrials.gov study NCT01518946. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intravenous Norepinephrine for Orthostatic Hypotension
ClinicalTrials.gov study NCT01285908. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa
ClinicalTrials.gov study NCT00782340. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Lundbeck TOMs Orthostatic Hypotension
ClinicalTrials.gov study NCT04510922. IPD Sharing: NO. Countries: 1. Publications: 21.
Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study
ClinicalTrials.gov study NCT02308124. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)
ClinicalTrials.gov study NCT00633880. IPD Sharing: Not stated. Countries: 4. Publications: 3.
Abdominal Binder to Treat Orthostatic Hypotension (OH) in Parkinson's Disease (PD)
ClinicalTrials.gov study NCT01971008. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension
ClinicalTrials.gov study NCT02586623. IPD Sharing: Not stated. Countries: 1. Publications: 1.
TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)
ClinicalTrials.gov study NCT02705755. IPD Sharing: NO. Countries: 1. Publications: 2.
Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults, supplement methods & tables, STROND checklist
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Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension
ClinicalTrials.gov study NCT02963181. IPD Sharing: NO. Countries: 1. Publications: 29.
Hypercapnia in Orthostatic Hypotension
ClinicalTrials.gov study NCT05295810. IPD Sharing: NO. Countries: 1. Publications: 6.
Spinal Cord Stimulation for Orthostatic Hypotension
ClinicalTrials.gov study NCT05230147. IPD Sharing: NO. Countries: 1. Publications: 3.
Treatment of Orthostatic Hypotension in Autonomic Failure
ClinicalTrials.gov study NCT00223691. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Breathing Device for Orthostatic Hypotension (OH)
ClinicalTrials.gov study NCT00962884. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Sinusoidal Galvanic Vestibular Stimulation for Neurogenic Orthostatic Hypotension / Syncope
ClinicalTrials.gov study NCT04976101. IPD Sharing: NO. Countries: 1. Publications: 43.
Abdominal Binders to Treat Orthostatic Hypotension in Parkinsonian Syndromes
ClinicalTrials.gov study NCT04920552. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Norepinephrine Transporter Blockade as a Pathological Biomarker in Neurogenic Orthostatic Hypotension
ClinicalTrials.gov study NCT01316666. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Head-up Tilt Sleeping to Alleviate Orthostatic Hypotension, Supine Hypertension and Nocturia in Parkinson's Disease
ClinicalTrials.gov study NCT05551377. IPD Sharing: YES. Countries: 1. Publications: 1.
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