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9
datasets available to search
ShareScore release 0.9.0
Dataset results
9 results for “osteoblast lineage cells”
Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells
<p>While sclerostin-neutralizing antibodies (Scl-Ab) transiently stimulate bone formation by activating Wnt signaling in osteoblast lineage cells, they exert sustained inhibition of bone resorption, suggesting an alternate signaling pathway by which Scl-Ab control osteoclast activity. Since sclerostin can activate platelet-derived growth factor receptors (PDGFRs) in osteoblast lineage cells in vitro and PDGFR signaling in these cells induces bone resorption through M-CSF secretion, we hypothesized that the prolonged anti-catabolic effect of Scl-Ab could result from PDGFR inhibition. We show here that inhibition of PDGFR signaling in osteoblast lineage cells is sufficient and necessary to mediate prolonged Scl-Ab effect on M-CSF secretion and osteoclast activity in mice. Indeed, sclerostin co-activates PDGFRs independently of Wnt/β-catenin signaling inhibition, by forming a ternary complex with LRP6 and PDGFRs in pre-osteoblasts. In turn, Scl-Ab prevents sclerostin-mediated co-activation of PDGFR signaling and consequent M-CSF up-regulation in pre-osteoblast cultures, thereby inhibiting osteoclast activity in pre-osteoblast/osteoclast co-culture assays. These results provide a new potential mechanism explaining the dissociation between anabolic and anti-resorptive effects of long-term Scl-Ab.</p>
O-GlcNAcylation Mediates Wnt-stimulated Bone Formation via Rewiring Aerobic Glycolysis in Osteoblast-lineage Cells
GEO Series GSE251951. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 During Osteoblast-Lineage Cell Differentiation
GEO Series GSE51515. Mus musculus. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array.
Co-culture of human hematopoietic stem cells with osteoblasts affects mono/macrophage versus erythroid lineage choice.
GEO Series GSE38091. Homo sapiens. 4 samples. Type: Expression profiling by array.
Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 During Osteoblast-Lineage Cell Differentiation [ChIP-Seq]
GEO Series GSE51513. Mus musculus. 22 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expression data from osteoblastic lineage cells isolated from normal and leukemic mice
GEO Series GSE48438. Mus musculus. 10 samples. Type: Expression profiling by array.
Genome-wide maps of chromatin state in pre-osteoblastic and lineage-committed cells.
GEO Series GSE186665. Mus musculus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 During Osteoblast-Lineage Cell Differentiation [gene expression]
GEO Series GSE51514. Mus musculus. 6 samples. Type: Expression profiling by array.
Mediators in Crohn’s disease influence the gene expression profiles of mesenchymal progenitor cells differentiated into the osteoblastic lineage.
GEO Series GSE20941. Homo sapiens. 12 samples. Type: Expression profiling by array.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.