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96 results for “osteocytes”
parallel-fibered bone; A5, osteocyte lacunae with well-preserved canaliculi; B3, osteocyte lacunae lacking canaliculi; B4, B5, growth pattern with preserved residuals of the thick annuli and zones (zo I–III) and thin annuli and zones (zo IV–VII); A6, growth pattern with preserved thin annuli and thick zones (zo I–IV), the dotted line marks the border between the perimedullary region and the cortex. Arrows in A5 and B3 indicate osteocyte lacunae; in B4, B5, and A6 indicate the annuli. Growth pattern in B4 figured on the lateral section side, in B5 and A5 on the ventral side; note the cortex thickness variation between B4 and B5. A1, A3, A4, A6, B1, B4, B5 in polarized light and A2, A5, B2, B3 in normal transmitted light. Abbreviations: an, annulus; ec, erosion cavity; pmr, perimedullary region; pos, primary osteon; sos, secondary osteon; zo, zone. in Palaeohistology helps reveal taxonomic variability in exceptionally large temnospondyl humeri from the Upper Triassic of Krasiejów, SW Poland
parallel-fibered bone; A5, osteocyte lacunae with well-preserved canaliculi; B3, osteocyte lacunae lacking canaliculi; B4, B5, growth pattern with preserved residuals of the thick annuli and zones (zo I–III) and thin annuli and zones (zo IV–VII); A6, growth pattern with preserved thin annuli and thick zones (zo I–IV), the dotted line marks the border between the perimedullary region and the cortex. Arrows in A5 and B3 indicate osteocyte lacunae; in B4, B5, and A6 indicate the annuli. Growth pattern in B4 figured on the lateral section side, in B5 and A5 on the ventral side; note the cortex thickness variation between B4 and B5. A1, A3, A4, A6, B1, B4, B5 in polarized light and A2, A5, B2, B3 in normal transmitted light. Abbreviations: an, annulus; ec, erosion cavity; pmr, perimedullary region; pos, primary osteon; sos, secondary osteon; zo, zone.
Dataset for Spatial Variations in the Osteocyte Lacuno-canalicular Network Density and Analysis of the Connectomic Parameters
<p>This dataset is a representative case of the loaded tibia of a C57BL/6 mouse at the mid-shaft. The image pixel size is 0.303 by 0.303 um, and the z-depth is 0.296 um. </p> <p>To generate, analyse, and quantify the osteocyte lacuno-canalicular network, it requires 'Tool for Image and Network Analysis (TINA)' which can be acqruied from https://gitlab.mpikg.mpg.de/rummler/TINA.git. A demonstration has been included on using TINA.</p>
Data for: Three-dimensional characterization of osteocyte volumes at multiple scales, and its relationship with bone biology and genome evolution in ray-finned fishes
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Data for arXiv:1702.04117: "The Small World of Osteocytes: Connectomics of the Lacuno-Canalicular Network in Bone"
<p>This dataset contains the raw confocal image stacks of the osteocyte lacuno-canalicular network in woven bone from mouse and fibrolamellar bone from sheep as described in "The Small World of Osteocytes: Connectomics of the Lacuno-Canalicular Network in Bone" (https://arxiv.org/abs/1702.04117). See the methods section of the manuscript for further detail. MATLAB code to reproduce the data plots in the figures can be downloaded from https://github.com/phi-max/OCY_connectomics.</p>
Data for: Osteocytes regulate senescence of bone and bone marrow
<p><span>The skeletal system contains a series of sophisticated cellular lineages arisen from the mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs), that determine the homeostasis of bone and bone marrow. Here we reasoned that osteocyte may exert a function in regulation of these lineage cell specifications and tissue homeostasis. Using a mouse model of conditional deletion of osteocytes by the expression of diphtheria toxin subunit </span><span>𝛼</span><span> (DTA) in dentin matrix protein 1 (DMP1) positive osteocytes, we demonstrated that partial ablation of DMP1 positive osteocytes caused severe sarcopenia, osteoporosis and degenerative kyphosis, leading to shorter lifespan in these animals. Osteocytes' reduction altered mesenchymal lineage commitment resulting in impairment of osteogenesis and induction of osteoclastogensis. Single cell RNA sequencing further revealed that hematopoietic lineage was mobilized towards myeloid lineage differentiation with expanded myeloid progenitors, neutrophils and monocytes, while the lymphopoiesis was impaired with reduced B cells in the osteocyte ablation mice. The acquisition of a senescence-associated secretory phenotype (SASP) in both osteoprogenic and myeloid lineage cells was the underlying cause. Together, we showed that osteocytes play critical roles in regulation of lineage cell specifications in bone and bone marrow through mediation of senescence.</span></p>
Data for: Osteocytes regulate senescence of bone and bone marrow
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Data from: Measurement, variation, and scaling of osteocyte lacunae: a case study in birds
Basic issues surrounding osteocyte biology are still poorly understood, including the variability of osteocyte morphology within and among bones, individuals, and species. Several studies have suggested that the volume or shape of osteocytes (or their lacunae) are related to bone and/or organismal growth rate or metabolism, but the nature of this relationship, if any, is unclear. Furthermore, several studies have linked osteocyte lacuna volume with genome size or growth rate and suggested that osteocyte lacuna volume is unrelated to body size. Herein the scaling of osteocyte lacuna volume with body mass, growth and basal metabolic rates, genome size, and red blood cell size is tested using a broad sample of extant birds within a phylogenetic framework. Over 12,000 osteocyte lacuna axes were measured in a variety of bones from 34 avian and four non-avian dinosaur species. Osteocyte lacunae in parallel-fibered bone are scalene ellipsoids; their morphology and volume cannot be reliably estimated from any single thin section, and using a prolate ellipsoid model to estimate osteocyte lacuna volume results in a substantial (ca. 2–7 times) underestimate relative to true lacunar volume. Orthogonal thin sections reveal that in birds, even when only observing parallel-fibered, primary, cortical bone, intra-skeletal variation in osteocyte lacuna volume and shape is very high (volumes vary by a factor of 5.4 among different bones), whereas variation among homologous bones of the same species is low (1.2–44%; mean = 12%). Ordinary and phylogenetically informed bivariate and multiple regressions demonstrate that in birds, osteocyte volume scales significantly but weakly with body mass and mass-specific basal metabolic rate and moderately with genome size, but not with erythrocyte size. Avian whole-body growth rate and osteocyte lacuna volume are weakly and inversely related. Finally, we present the first three-dimensionally calculated osteocyte volumes for several non-avian dinosaurs, which are much larger than previously reported values and smaller than those of large extant avians. Osteocyte volumes estimated from a single transverse section and assuming prolate morphology, as done in previous studies, are relative underestimates in theropod dinosaurs compared to sauropod dinosaurs, raising the possibility that no major change in osteocyte volumes (and genome size) occurred within Theropoda on the lineage leading to birds. Osteocyte volume is intertwined with several organismal attributes whose relative importance varies at a number of hierarchical levels.
Figure 1. H&E in Resveratrol-Tempeh reduce micronucleus frequencies bone marrow cells and stimulate osteocyte proliferation in aluminum chloride-induced mice
Figure 1. H&E staining of the femur bone mice. (A) untreated-group, 10X20; (B) Al-treated group 10X10; (C) Al+Res5-treated group, 10X10 and (D) Al+Res10-treated group, 10X10. Green star: Bone trabecular, Blue arrow: osteocytes, Red arrow: empety lacunae.
Data from: Measurement, variation, and scaling of osteocyte lacunae: a case study in birds
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Mature primary human osteocytes in mini organotypic cultures secrete FGF23 and PTH1-34-regulated sclerostin
GEO Series GSE227994. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
The effects of mitochondrial damages under stress or during aging on osteocytes networks homeostasis
GEO Series GSE235103. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
DNase-seq from osteocyte (ENCSR818HHN)
GEO Series GSE215487. Homo sapiens. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Osteoblast to Osteocyte Transition: Epigenetic Changes and Response to the Vitamin D3 Hormone [RNA-seq]
GEO Series GSE54783. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression [primary chondrocytes]
GEO Series GSE284358. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The osteocyte transcriptome is extensively dysregulated in mouse models of Osteogenesis Imperfecta
GEO Series GSE154748. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Osteocyte CIITA Aggravates Osteolytic Bone Lesions in Myeloma
GEO Series GSE200987. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.
GEO Series GSE276370. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Control ChIP-seq from osteocyte (ENCSR702WFF)
GEO Series GSE169778. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mint-ChIP-seq from osteocyte (ENCSR664DNR)
GEO Series GSE188004. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23 [RNA-seq]
GEO Series GSE205791. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.