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25 results for “oxidative physiology”
Correlated evolution of oxidative physiology and MHC-based immunosurveillance in birds
<p>Maintenance and activation of the immune system incurs costs, not only in terms of substrates and energy, but also via collateral oxidative damage to host cells or tissues during immune response. So far, associations between immune function and oxidative damage have been primarily investigated at intra-specific scales. Here, we hypothesized that pathogen-driven selection should favour evolution of effective immunosurveillance mechanisms (e.g. Major Histocompatibility Complex, MHC) and antioxidant defences to mitigate oxidative damage resulting from immune function. Using phylogenetically-informed comparative approaches, we provided evidence for correlated evolution of host oxidative physiology and MHC-based immunosurveillance in birds. Species selected for more robust MHC-based immunosurveillance (higher gene copy numbers and allele diversity) showed stronger antioxidant defences, although selection for MHC diversity still showed a positive evolutionary association with oxidative damage to lipids. Our results indicate that historical pathogen-driven selection for highly duplicated and diverse MHC could have promoted the evolution of efficient antioxidant mechanisms, but these evolutionary solutions may be insufficient to keep oxidative stress at bounds. Although the precise nature of mechanistic links between the MHC and oxidative stress remains unclear, our study suggests that a general evolutionary investment in immune function may require co-adaptations at the level of host oxidative metabolism.</p>
Correlated evolution of oxidative physiology and MHC-based immunosurveillance in birds
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Strong species differences in life-history do not predict oxidative stress physiology or sensitivity to an environmental oxidant
1. Species typically align along a fast-slow life-history continuum, yet it is not clear to what extent oxidative stress physiology can be integrated with this continuum to form a 'pace-of-life syndrome', especially so in invertebrates. This is important, given the assumed role of oxidative stress in mediating life-history trade-offs, and the prediction that species with a faster pace should be more vulnerable to oxidative stress. 2. We tested whether a species' life-history pace, here represented by its growth rate, can predict species-level differentiation in physiology and sensitivity to oxidative stress. Therefore, we exposed four species of Ischnura damselflies that strongly align along a fast-slow life-history continuum to different levels of ultraviolet (UV) radiation. We measured an extended set of physiological traits linked to the pace-of-life: standard metabolic rate (SMR), oxidative stress physiology (antioxidant enzymes and oxidative damage), and defence/condition traits (investment in immune function, energy storage, and structural defence). 3. Despite strong species differences in growth rate and physiology, growth rate did not predict species-level differentiation in physiology. Hence there was no support for the integration of metabolic rate, oxidative stress physiology or defence/condition traits into a species-level syndrome. 4. UV exposure affected nearly all traits: it reduced growth rate and increased metabolic rate, affected all oxidative stress physiology traits and increased the two defence traits (immune function, and melanin content). Nevertheless, the pace-of-life based on growth rate did not predict sensitivity to UV. Instead, the observed pattern of investment in structural UV defence (melanin) might have reduced the need for enzymatic antioxidant defence, this way potentially decoupling the covariation between the life-history pace and oxidative stress physiology. 5. The absence of an integrated axis of life-history and physiological variation indicates no major constraints for the evolution of these traits among the studied damselfly species. Our study highlights that ecological differences between species may decouple covariation between species' life-history pace and their physiology, as well as their sensitivity to environmental stressors. 30-Mar-2020
Variation in oxidative status, but not structural and physiological development, associated with changing ontogenetic environments
<p><span>Despite the potential for temporally-dependent relationships between trait values and fitness (e.g., as juveniles approach life-stage transitions such as fledging), how developmental stage affects canalization (a measure of robustness to environmental variation) of morphological and physiological traits is rarely considered. To test the sensitivity of morphological and physiological traits to environmental variation in two developmental stages, we manipulated brood size at hatch in European starlings (<em>Sturnus vulgaris</em>) and cross-fostered chicks between enlarged and reduced broods approaching fledging.</span><span> We measured body size (mass, tarsus, wing length) and physiological state (aerobic capacity, oxidative status) at asymptotic mass on day 15, then cross-fostered chicks between 'high' and 'low' quality environments and assessed the same traits again on day 20, after five days of pre-fledging mass recession. Chicks in reduced broods were heavier at asymptotic mass and had lower reactive oxygen metabolites than enlarged broods, while structural size, aerobic capacity, and antioxidant capacity were unaffected by experimental brood size. The observed canalization of structural and physiological traits during early development was maintained after cross-fostering, during late development. However, in contrast to early development, antioxidant capacity approaching fledging appeared sensitive to environmental conditions, as trajectories varied by cross-fostering treatment. Elevated reactive oxygen metabolites observed after early development in enlarged brood chicks were maintained after cross-fostering, suggesting canalized development in low-quality environments could produce oxidative costs that carry over between life-stages, even when conditions improve. These data reveal trait-specific relationships between environmental conditions and development and highlight how natal environment effects may vary by developmental stage.</span></p>
Effect of Infusion of Yerba Mate on Oxidative Stress, Physiology, and Performance of Trained Cyclists
ClinicalTrials.gov study NCT04642144. IPD Sharing: NO. Countries: 1. Publications: 1.
Phylogenetic relationships of immune function and oxidative physiology with sexual selection and parental effort in male and female birds
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Strong species differences in life-history do not predict oxidative stress physiology or sensitivity to an environmental oxidant
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Variation in oxidative status, but not structural and physiological development, associated with changing ontogenetic environments
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Data from: Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and non-parallel physiological divergence
Across multiple lakes in North America, lake whitefish (Coregonus clupeaformis) have independently evolved "dwarf" and "normal" sympatric species pairs that exhibit pronounced phenotypic and genetic divergence. In particular, traits associated with metabolism have been shown to be highly differentiated between whitefish species. Here, we examine the transcription of genes associated with all five mitochondrial and nuclear genome-encoded oxidative phosphorylation (OXPHOS) complexes, the primary physiological mechanism responsible for the production of ATP, in whitefish species pairs from Cliff Lake and Webster Lake in Maine, USA. We observed OXPHOS gene transcription divergence between dwarf and normal whitefish in each of the two lakes, with the former exhibiting transcription upregulation for genes associated with each of the OXPHOS complexes. We also observed a significant influence of lake on transcription levels for some of the genes, indicating that inter-lake ecological or genetic differences are contributing to variation in OXPHOS gene transcription levels. Together, our results support the hypothesis that metabolic divergence is a critical adaptation involved in whitefish speciation, and implicate OXPHOS gene upregulation as a factor involved in meeting the enhanced energetic demands of dwarf whitefish. Further examination of the links between this critical physiological pathway and ecological and genetic variation will provide insight into the fine-scale evolutionary dynamics at work in nature.
Theoretical insights into the antiradical activity and copper-catalyzed oxidative damage of mexidol in the physiological environment
<p>This dataset contains data from the calculations described in the paper: "Quan V. Vo*, Nguyen Thi Hoa, <span class="fontstyle01"><span>Mai Van Bay, </span></span>Adam Mechler, Theoretical insights into the antiradical activity and copper-catalyzed oxidative damage of mexidol in the physiological environment. Royal Society Open Science. 2021.</p> <p>In this study, the hydroperoxyl radical scavenging activity of<b> MD </b>was studied to establish baseline antioxidant activity, followed by an investigation of the effect of<b> MD </b>on the <span class="fontstyle01"><span>copper-catalyzed oxidative damage in</span></span> <span class="fontstyle01"><span>biological systems, using computational methods. It was found that</span></span><span class="fontstyle01"><span><b> MD </b></span></span><span class="fontstyle01"><span>exhibits moderate </span></span>radical scavenging activity against HOO<sup>·</sup> in physiological environments. The activity in aqueous solution is defined by the single electron transfer mechanism of the anion state; however in nonpolar environments the formal hydrogen transfer pathway dominates at the O3-H bond. It was also confirmed that<b> MD </b><span class="fontstyle01"><span>can chelate Cu (II), forming complexes that are much harder to reduce than free Cu (II):</span></span><span class="fontstyle01"><span><b> MD </b></span></span><span class="fontstyle01"><span>chelation completely quenches the Cu (II) reduction by ascorbic acid and suppresses the rate of reduction reaction by O<sub>2</sub></span></span><span class="fontstyle01"><span><sup>·</sup></span></span><span class="fontstyle01"><span><sup>-</sup></span></span><span class="fontstyle01"><span> that are the main reductants of Cu (II) in biological environments. Therefore,</span></span><span class="fontstyle01"><span><b> MD </b></span></span><span class="fontstyle01"><span>exerts its anti- HO</span></span><span class="fontstyle01"><span><sup>·</sup></span></span><span class="fontstyle01"><span><sup> </sup></span></span><span class="fontstyle01"><span>activity primarily as an OIL-1 inhibitor. </span></span></p>
Theoretical insights into the antiradical activity and copper-catalyzed oxidative damage of mexidol in the physiological environment
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Data from: Oxidative phosphorylation gene transcription in whitefish species pairs reveals patterns of parallel and non-parallel physiological divergence
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Data from: Weak phylogenetic signal in physiological traits of methane-oxidizing bacteria
The presence of phylogenetic signal is assumed to be ubiquitous. However, for microorganisms, this may not be true given that they display high physiological flexibility and have fast regeneration. This may result in fundamentally different patterns of resemblance, that is, in variable strength of phylogenetic signal. However, in microbiological inferences, trait similarities and therewith microbial interactions with its environment are mostly assumed to follow evolutionary relatedness. Here, we tested whether indeed a straightforward relationship between relatedness and physiological traits exists for aerobic methane-oxidizing bacteria (MOB). We generated a comprehensive data set that included 30 MOB strains with quantitative physiological trait information. Phylogenetic trees were built from the 16S rRNA gene, a common phylogenetic marker, and the pmoA gene which encodes a subunit of the key enzyme involved in the first step of methane oxidation. We used a Blomberg's K from comparative biology to quantify the strength of phylogenetic signal of physiological traits. Phylogenetic signal was strongest for physiological traits associated with optimal growth pH and temperature indicating that adaptations to habitat are very strongly conserved in MOB. However, those physiological traits that are associated with kinetics of methane oxidation had only weak phylogenetic signals and were more pronounced with the pmoA than with the 16S rRNA gene phylogeny. In conclusion, our results give evidence that approaches based solely on taxonomical information will not yield further advancement on microbial eco-evolutionary interactions with its environment. This is a novel insight on the connection between function and phylogeny within microbes and adds new understanding on the evolution of physiological traits across microbes, plants and animals.
Physiological Effects of Nitrous Oxide on Anaesthesia
ClinicalTrials.gov study NCT01092923. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Weak phylogenetic signal in physiological traits of methane-oxidizing bacteria
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Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase a1s/sa2s/s Mouse Model of High Affinity for Cardiotonic Steroids
GEO Series GSE169734. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Physiological and Molecular Characterization of an Oxidative Stress-Resistant Saccharomyces cerevisiae Strain Obtained by Evolutionary Engineering
GEO Series GSE184952. Saccharomyces cerevisiae. 6 samples. Type: Non-coding RNA profiling by array.
Transcriptome and physiological analysis of class III peroxidase family in ice plant seedlings in response to salt-induced oxidative stress
GEO Series GSE277109. Mesembryanthemum crystallinum. 2 samples. Type: Expression profiling by high throughput sequencing.
Genetic and Physiological Aspects of Oxidative Profile in Sleep and Well-succeed Aging
ClinicalTrials.gov study NCT01480037. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Physiological, Biochemical, and Transcriptomic Analyses Reveal the Response to Oxidative Stress Under Drought Stress in Castor (Ricinus communis L.)
GEO Series GSE252706. Ricinus communis. 18 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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