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41 results for “oxysterol”
Data_text section 3.3_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data from kinetic characterization (Km and vmaxapp) described in text section 3.3 of Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains values from kinetic characterization (10.1016_j.jsbmb.2019.03.011_text3.3_Km_vmax) described in text section 3.3 corresponding to raw data obtained from LC-MS/MS analysis provided as three files in CSV format (31003A-179400_date_name_25Oxysterol_4_10_1-3). All further experiment related information and subsequent data analysis provided as two meta-data-files: (31003A-179400_date_name_25Oxysterol_4_9_M_1-2) as TXT and pdf format.</p>
Data_Figure 2_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of figure 2 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure in PNG format, (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_Fig. 2). Corresponding raw data obtained from LC-MS/MS analysis provided as eight files in CSV format (31003A-179400_Date_Name_25Oxysterol_4_Dataset_1-4). All further experiment related information and subsequent data analysis provided as two meta-data-files (31003A-179400_Date_Name_25Oxysterol_4_Dataset _M_1-2) as TXT format and PDF format.</p>
Data_Figure 4_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of figure 4 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset ((doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_Fig. 4). Corresponding raw data obtained from liquid scintillation analysis provided as 10 files in CSV format (31003A-179400_date_KB_25Oxysterol_11_dataset_1-4). All further experiment related information and subsequent data analysis provided as three meta-data-files (31003A-179400_date_name_25Oxysterol_11_dataset_M_1) as TXT format.</p>
Data_Figure 1_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of figure 1 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_Fig. 1). Corresponding raw data obtained from LC-MS/MS analysis provided six files in CSV format (31003A-179400_Date_Name_25Oxysterol_4_Dataset _1-3). All further experiment related information and subsequent data analysis provided as two meta-data-files (31003A-179400_Date_Name_25Oxysterol_4_Dataset_M_1-2) as TXT format and PDF format</p>
7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome
<p>Defective 3beta-hydroxysterol-delta<sup>7 </sup>-reductase (DHCR7) in the developmental disorder, Smith-Lemli-Opitz syndrome (SLOS), results in deficiency in cholesterol and accumulation of its precursor, 7-dehydrocholesterol (7-DHC). Here, we show that loss of <i>DHCR7</i> causes accumulation of 7-DHC-derived oxysterol metabolites, premature neurogenesis, and perturbation of neuronal localization in developing murine or human cortical neural precursors, both <i>in vitro</i> and <i>in vivo</i>. We found that a major oxysterol, 3b,5a-dihydroxycholest-7-en-6-one (DHCEO), mediates these effects by initiating crosstalk between glucocorticoid receptor (GR) and neurotrophin receptor kinase TrkB. Either loss of <i>DHCR7</i> or direct exposure to DHCEO causes hyperactivation of GR and TrkB and their downstream MEK-ERK-C/EBP signaling pathway in cortical neural precursors. Moreover, direct inhibition of GR activation with an antagonist or inhibition of DHCEO accumulation with antioxidants rescues the premature neurogenesis phenotype caused by the loss of <i>DHCR7</i>. These results suggest that GR could be a new therapeutic target against the neurological defects observed in SLOS.</p>
7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome
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Data_text section 3.1_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data from kinetic characterization (Km and vmaxapp) described in text section 3.1 of Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains values from kinetic characterization (31003A-179400_date_name_25Oxysterol_4_9_M_1) described in text section 3.1 corresponding to raw data obtained from LC-MS/MS analysis provided as three files in CSV format (31003A-179400_date_name_25Oxysterol_4_9_1-3). All further experiment related information and subsequent data analysis provided as two meta-data-files: (31003A-179400_date_name_25Oxysterol_4_9_M_1) as TXT format.</p>
Data_supplemental figure 2_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of supplemental figure 2 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_Fig. S2). Data obtained from LC-MS/MS measurements subsequent data analysis (31003A-179400_date_name_25Oxysterol_4_8_1-3) provided as three CSV file and meta-data-files (31003A-179400_date_name_25Oxysterol_4_8_M_1-2) as TXT and PDF format.</p>
Data_Figure 7_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of figure 7 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_Fig. 7). Corresponding raw data obtained from docking calculation analysis and calculation provided as two files in TXT format (31003A-179400_date_name_ 25Oxysterol_19_dataset_1). All further experiment related information and subsequent data analysis provided as two meta-data-files (31003A-179400_date_name_25Oxysterol_19_dataset_M) as TXT format.</p>
Data_supplemental table 1_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of supplemental table 1 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original table as PNG format. Corresponding data for RT-PCR analysis provided as two meta-data-files (31003A-179400_date_name_25Oxysterol_3_1_M_1-2) as TXT and PDF format.</p>
Data_Figure 3_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of figure 3 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure and text passage 3.3 as two files as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_Fig. 3). Corresponding raw data obtained from LC-MS/MS analysis provided as six files in CSV format (31003A-179400_Date_Name_25Oxysterol_4_Dataset_1-3). All further experiment related information and subsequent data analysis provided as four meta-data-files (31003A-179400_ Date_Name_25Oxysterol_4_Dataset_M_1-2) as TXT format and PDF format.</p>
Data_supplemental figure 3_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of supplemental figure 3 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_FigS3). Corresponding raw data obtained from liquid scintillation analysis provided as three files in CSV format (31003A-179400_date_name_27Oxysterol_11_7_1-3). All further experiment related information and subsequent data analysis provided as meta-data-file (31003A-179400_date_name_25Oxysterol_11_7_M) as TXT format.</p>
Data_Figure 5_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of figure 5 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset ((doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_Fig. 5). Corresponding raw data obtained from liquid scintillation analysis provided as six files in CSV format (31003A-179400_date_KB_25Oxysterol_11_dataset_1-4). All further experiment related information and subsequent data analysis provided as two meta-data-file: (31003A-179400_date_name_27Oxysterol_11_dataset_M_1,) as TXT format.</p>
Data_Figure 6_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of figure 6 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset ((doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_Fig. 6). Corresponding raw data obtained from docking calculation analysis and calculations provided as four files in TXT format (31003A-179400_Date_name_25Oxysterol_19_dataset_1). All further experiment related information and subsequent data analysis provided as four meta-data-files (31003A-179400_date_name_25Oxysterol_19_dataset_M1) as TXT format.</p>
Data_Figure 8_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of figure 8 from Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_Fig. 8). Corresponding raw data obtained from xCelligence measurement and fluorescence analysis (FLIPR) provided as seven files in CSV format (31003A-179400_date_name_25Oxysterol_9_dataset_1-3 and 31003A-179400_date_name_25Oxysterol_20_dataset_1-3). All further experiment related information and subsequent data analysis provided as two meta-data-files (31003A-179400_date_name_25Oxysterol_technique_1_M) as TXT format.</p>
Data_supplemental figure 1_Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
<p>Data of supplemental figure 1 Enzymatic interconversion of the oxysterols 7β,25 dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2</p> <p>Dataset (doi:<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>) contains the original figure as PNG format (<a href="https://doi.org/10.1016/j.jsbmb.2019.03.011">10.1016/j.jsbmb.2019.03.011</a>_FigS1). Data obtained from LC-MS/MS measurements subsequent data analysis (31003A-179400_date_name_25Oxysterol_4_7_1) provided as one CSV file and meta-data-files (31003A-179400_date_name_25Oxysterol_4_7_M_1) as PDF format.</p>
Datasets generated and/or analysed for paper entitled: "Oxysterol 7α,25OHC synthesising enzymes, CH25H and CYP7B1, are upregulated in the blood-brain barrier during inflammation"
<p>Images collected and datasets generated and/or analyzed for a paper entitled: "Oxysterol 7α,25OHC synthesising enzymes, CH25H and CYP7B1, are upregulated in the blood-brain barrier during inflammation"</p>
Dietary Oxysterols and β-Cell Function Among African Americans
ClinicalTrials.gov study NCT05072587. IPD Sharing: NO. Countries: 1. Publications: 39.
Feasibility Study for the Determination of Oxysterols in Patients With Breast Cancer Receiving Hormonal Therapy With Tamoxifen or Not
ClinicalTrials.gov study NCT01553903. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Withanolide analogues disrupt a leukemic dependency on cholesterol transport by inhibiting the oxysterol-binding protein OSBP [RNA-Seq]
GEO Series GSE226847. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
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