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58 results for “p38 MAPK”
Data related to "Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27."
<p>Data used to generate figures, as well as all uncropped blots. Article abstract: "Maintenance of lysosomal integrity is essential for cell viability. Upon injury, lysosomes may be targeted for degradation via a selective form of autophagy known as lysophagy. The engulfment of a damaged lysosome by an autophagosome is mediated by the recruitment of adaptor proteins, including SQSTM1/p62. p62 promotes lysophagy via the formation of phase separated condensates in a mechanism that is regulated by the heat shock protein HSP27. Here, we demonstrate a direct interaction between HSP27 and p62. We used structural modeling to predict the binding interface between HSP27 and p62 and identify several disease-associated mutations that map to this interface. We used proteomics to identify post-translational modifications of HSP27 that regulate HSP27 recruitment to stressed lysosomes, finding robust phosphorylation at several serine residues. Next, we characterized the upstream signaling mechanism leading to HSP27 phosphorylation, and found that p38 MAPK and its effector kinase MK2 are activated upon lysosomal damage by the kinase mTOR and the production of intracellular reactive oxygen species (ROS). Increased ROS activates p38 MAPK, which in turn allows MK2-dependent phosphorylation of HSP27. Depletion of HSP27 or the inhibition of HSP27 phosphorylation alters the dynamics of p62 condensates on stressed lysosomes, significantly inhibiting p62-dependent lysophagy. Thus, we define a novel lysosomal quality control mechanism in which lysosomal injury triggers a p38 MAPK/MK2 signaling cascade promoting p62-dependent lysophagy. Further, this signaling cascade is activated by many cellular stressors, including oxidative and heat stress, suggesting that other forms of selective autophagy may be regulated by p38 MAPK/MK2/HSP27." </p>
p38 Mitogen-Activated Protein Kinase (MAPK) and Steroid Insensitivity in Asthma
ClinicalTrials.gov study NCT00676572. IPD Sharing: NO. Countries: 1. Publications: 1.
Proof-of-Concept Study of a Selective p38 MAPK Alpha Inhibitor, Neflamapimod, in Subjects With Mild Alzheimer's Disease
ClinicalTrials.gov study NCT03402659. IPD Sharing: NO. Countries: 5. Publications: 2.
MAPK p38 and NFkB activity dynamics in macrophages upon innate immune stimulation
<p>Dataset (.mat structure) containing single cell p38 and NFkB activity dynamics in macrophages (iMPDMs) upon innate immune stimulation (LPS, TNF, P3C4, CpG) (1 h baseline + app 8 h stimulation).</p> <p>Two biological replicates per stimulation condition are included. 6 doses per stimulus are included.</p> <p>Signaling dynamics are quantified using live cell microscopy followed by automated image analysis by MACKtrack.</p> <p>Datasets include dynamic features ('metrics'), MACKtrack quantification outputs ('measure'), info on experimental (esp. dose), tracking, and quantification parameters, and filtering outcomes ('info').</p>
NF-kB suppresses the breast cancer cell's growth via the p38 MAPK inhibitor
Open the record for dataset details and reuse information.
NRF2-independent iron-triggered signaling via MAPK p38-ETS1 regulates LSEC Bmp6 mRNA expression
GEO Series GSE235976. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Influence of p38 MAPK (PMK-1) on the heat stress response of C. elegans
GEO Series GSE41205. Caenorhabditis elegans. 2 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of p38 MAPK in DC progenitor cells endows DCs with superior immunogenicity
GEO Series GSE57879. Mus musculus. 6 samples. Type: Expression profiling by array.
Enhancement of melanoma aggressiveness via p38-MAPK, HIF-1α pathways, and metabolic reprogramming induced by Candida albicans
GEO Series GSE285124. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
FGF9 Promotes Mouse Spermatogonial Stem Cell Proliferation Mediated by p38 MAPK Signaling [single-cell RNA-seq]
GEO Series GSE160061. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Dual inhibition of P38 MAPK and JNK pathways preserves stemness markers and alleviates premature activation of Muscle Stem Cells during isolation
GEO Series GSE268475. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
A p38 MAPK-ROS axis fuels proliferation stress and DNA damage during CRISPR/Cas9 gene editing in Hematopoietic Stem and Progenitor Cells
GEO Series GSE238189. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Microenvironmental CXCL12 Deletion Enhances Flt3-ITD Acute Myeloid Leukemia Stem Cell Response to Therapy by Reducing p38 MAPK Signaling
GEO Series GSE212428. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Tetraspanin family member, CD82, regulates expression of EZH2 via inactivation of p38 MAPK signaling in leukemia cells. The novel function of CD82 and its impact on BCL2L12 via AKT/STAT5 signal pathwa
GEO Series GSE64527. Homo sapiens. 6 samples. Type: Expression profiling by array.
FGF9 Promotes Mouse Spermatogonial Stem Cell Proliferation Mediated by p38 MAPK Signaling [bulk RNA-seq]
GEO Series GSE160062. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
S100A8/A9 induced by interaction with macrophages in esophageal squamous cell carcinoma promotes the migration and invasion of cancer cells via Akt and p38 MAPK pathways
GEO Series GSE174796. Homo sapiens. 1 samples. Type: Expression profiling by array.
NRF2-independent iron-triggered signaling via MAPK p38-ETS1 regulates LSEC Bmp6 mRNA expression [I]
GEO Series GSE235692. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway
GEO Series GSE192521. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Lung emphysema can be elicited by nanoparticle triggered, p38 MAPK mediated virus reactivation
GEO Series GSE223818. Mus musculus. 64 samples. Type: Expression profiling by array.
Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma
GEO Series GSE281549. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.