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ShareScore release 0.9.0
Dataset results
14 results for “pH-responsive”
Dataset for "Biocompatible Rhamnolipid Self-Assemblies with pH-Responsive Antimicrobial Activity"
<p>This dataset provides the raw data supporting the paper: Biocompatible Rhamnolipid Self-Assemblies with pH-Responsive Antimicrobial Activity. It comprises SAXS data (Figure 2, Figure 3, Figure 4, Figure 5, Figure S2 and Figure S4), cryo-TEM images (Figure 2D, Figure 4D, Figure 5D, Figure 5E), Zeta-potential measurment (Figure 7), DLS data (Figure 8, Figure S5, Figure S6, Figure S7, Figure S8 and Table S2), Antimicrobial activity data (Figure 9, Table 1, Figure S9, Figure S10, Figure S12, Figure S13, Figure S14, Figure S15, Figure S16 and Table S3), Cytotoxicity data (Figure 10), Colloidal stability images (Figure S1 and Figure S3) and Biofilm inhibition and biofilm eradication assay (Figure S11).</p><p> </p>
pH-responsive aminolipid nanocarriers for antimicrobial peptide delivery
<p>Raw data for the paper entitled, "pH-responsive aminolipid nanocarriers for antimicrobial peptide delivery" published in the Journal of Colloid and Interface Science on 11 June 2021.</p> <p> </p> <p>Abstract:</p> <p>pH-responsive aminolipid self-assemblies are promising platforms for the targeted delivery of antimicrobial peptides (AMPs), with the potential to improve their therapeutic efficiency and physicochemical stability. pH-sensitive nanocarriers based on dispersed self-assemblies of 1,2-dioleoyl-3-dimethylammonium-propane (DODAP) with the human cathelicidin LL-37 in excess water were characterized at different pH values using small-angle X-ray scattering, cryogenic transmission electron microscopy, and dynamic light scattering. Fluorescence and electrophoretic mobility measurements were used to probe the encapsulation efficiency of LL-37 and the nanocarriers’ surface potential. Upon decreasing pH in the DODAP/water systems, normal oil-in-water emulsions at pH ≥ 5.0 transitioned to emulsions encapsulating inverse hexagonal and cubic structures at pH between 4.5 and 4.0, and mostly positively-charged vesicles at pH < 4.0. These colloidal transformations are driven by the protonation of DODAP upon pH decrease. The larger lipid-water interfacial area provided by the DODAP self-assemblies at pH ≤ 4.5 allowed for an adequate encapsulation efficiency of LL-37, favouring the formation of vesicles in a concentration-dependent manner. Contrary, LL-37 was found to dissociate from the emulsion droplets at pH 6.0. The knowledge on the pH-triggered self-assembly of LL-37 and DODAP, combined with the results on peptide release from the structures contribute to the fundamental understanding of lipid/peptide self-assembly. The results can guide the rational design of future pH-responsive AMP delivery systems.</p>
Data to the manuscript 'Imperfect cross-linking of Xanthan for pH-responsive bio-based composite moist wound dressings by stencil printing'
<p>Evaluation data for the manuscript stated above. For follow-up evaluation, files have to be arranged according to file designation in the scripts uploaded. There is no additional description of how to arrange. Please feel free to contact the first author for help and information.</p>
CELLOIDS: pH-responsive DOPC Giant Unilamellar Vesicles with and without Linoleic Acid
<p>As part of the CELLOIDS project, one of our main research focuses is exploring the feasibility of making the microrobot's membrane responsive to a pH gradient. Specifically, we investigated the incorporation of linoleic acid into Giant unilamellar vesicles composed of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine).</p> <p>The provided dataset compiles the diameters of liposomes prepared with DOPC (3.18 mM), DOPC:LA (linoleic acid) at a molar ratio of 100:1, and DOPC:LA at a molar ratio of 50:1. These liposomes were placed in buffers at both pH 6 and pH 7, simulating conditions similar to the tumor microenvironment. Our objective was to assess the stability of these liposomes under these conditions.</p> <p>In detail, we carefully prepared liposomes with varying molar ratios of DOPC and linoleic acid to determine the optimal amount of linoleic acid that induces membrane deformation while maintaining the structural integrity of the liposomes in acidic solutions. Subsequently, we subjected the liposomes to testing at the specified concentrations and compared their behavior under two different pH values. Finally, we observed the samples using a phase-contrast microscope immediately after the addition of the solutions and after a one-hour incubation period.</p>
pH-Responsive, Lysine-Based, Hyperbranched Polymers Mimicking Endosomolytic Cell-Penetrating Peptides for Efficient Intracellular Delivery-DATA
<p>Original data and supporting data for the paper entitled "pH-Responsive, Lysine-Based, Hyperbranched Polymers Mimicking Endosomolytic Cell-Penetrating Peptides for Efficient Intracellular Delivery".</p>
A pH-responsive amphiphilic hydrogel based on pseudo-peptides and poly(ethylene glycol) for oral drug delivery
<p>The original data for the paper titled "A pH-responsive amphiphilic hydrogel based on pseudo-peptides and poly(ethylene glycol) for oral drug delivery"</p>
MRI-based sensing of pH-responsive content release from mesoporous silica nanoparticles
<p>A proof of principle study toward developing a novel methodology which could be applicable for a non-invasive monitoring of the release of cargo molecules from therapeutic and diagnostic nanoparticles, as well as for possible monitoring of tissue pH variations. This was achieved by quantifying changes in longitudinal relaxation time (T<sub>1</sub>) before and after the pH-responsive release of contrast agents, for magnetic resonance imaging (MRI), from the pores of mesoporous silica nanoparticles (MSNs). The pores were filled with the FDA-approved contrast agent Gadobutrol (GdB), and its retention inside the pores ensured by covalent attachment of β-cyclodextrin monoaldehyde to hydrazine-functionalized MSN, through acidification-cleavable hydrazone linkage. The release kinetics of GdB was measured by fluorescence spectroscopy which revealed that the release of the contrast agent was enhanced at pH 5.0 in comparison to the release at pH 6.0 and 7.4. Furthermore, the changes in T<sub>1</sub>, occurring in response to the enhanced release of GdB from the pores of MSN at weakly acidic conditions, were successfully demonstrated by MRI measurements. It is envisioned that this approach using contrast agent-loaded nanoparticles before the treatment with the drug-filled analogs, could be applied in the future for tracking the locations and efficacies of nanomedicines for therapeutic cargo delivery.</p>
pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers
<div> <p>Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.</p> <p> </p> </div> <h2>Notes</h2>
Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme
<p>Using nanoparticles for controlled drug delivery to cancer, in response to its weakly acidic environment, represents a promising approach toward increasing the effectiveness and reducing the adverse effects of cancer therapy. Hence, the aim of this study is to construct novel mesoporous silica nanoparticle (MSN)-based acidification-responsive drug delivery systems for targeted cancer therapy. Herein, the surface of MSN is covalently functionalized with Ir(III)-based complex through a pH-cleavable hydrazone-based linker and characterized by nitrogen sorption, SEM, FTIR, EDS, TGA, DSC, DLS, and zeta potential measurements. Enhanced release of Ir(III)-complexes is evidenced by UV/VIS spectroscopy at the weakly acidic environments (pH 5 and pH 6) in comparison to the release at physiological conditions. The in vitro toxicity of the prepared materials is tested on healthy MRC-5 cells while their potential for the efficient treatment of glioblastoma multiforme is demonstrated on the U251 cell line.</p>
Targeting pH-responsive Transcriptional Regulation of Peptidoglycan Cleavage Potentiates Fast Clearance of Mycobacterium tuberculosis with Frontline Antibiotics
GEO Series GSE166806. Mycobacterium tuberculosis; Mycolicibacterium smegmatis. 60 samples. Type: Expression profiling by high throughput sequencing.
Ginsenoside Rg3 Reduces the Toxicity of Graphene Oxide Used for pH-Responsive Delivery of Doxorubicin to Liver and Breast Cancer Cells
GEO Series GSE185139. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Evaluation of the Cell Detachment Ratio on pH-responsive Chitosan as a Prognostic Factor in Lung Cancer
ClinicalTrials.gov study NCT04218188. IPD Sharing: Not stated. Countries: 1. Publications: 0.
RNA-seq analysies of pH-responsive gene expression in Helicobacter pylori
GEO Series GSE165055. Helicobacter pylori. 24 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis of pH-responsive gene expression in Helicobacter pylori [ArsS]
GEO Series GSE165056. Helicobacter pylori. 24 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.