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9 results for “palatable formulations”
Refined tamoxifen administration in mice by encouraging voluntary consumption of palatable formulations.
<p>Drug administration in preclinical rodent models is essential for research and the development of novel therapies. Compassionate administration methods have been developed, but these are mostly incompatible with water-insoluble drugs such as <span>tamoxifen</span> <span>or</span> do not <span>allow for</span> precise timing or dosing of the drugs. <span>For more than two decades, tamoxifen has been administered by oral gavage or injection to </span>CreER<sup>T2</sup>/loxP gene-modified mouse models<span> </span>to <span>spatiotemporally control gene expression,</span><span> with the numbers of such inducible models </span><span>steadily increasing in recent years. </span>Animal-friendly procedures <span>for</span> accurately administering <span>tamoxifen or </span><span>other water-insoluble </span><span>drugs </span>would, therefore, have an important impact on animal <span>welfare.</span> <span>Based on a previously published micropipette feeding protocol, we developed palatable formulations to encourage voluntary consumption of tamoxifen. We </span><span>evaluated</span><span> </span><span>the acceptance of the new formulations by mice during training and treatment and assessed the efficacy of </span><span>tamoxifen-mediated induction of </span>CreER<sup>T2</sup>/loxP-dependent reporter <span>gene</span><span>s</span><span>.</span> <span>Both sweetened </span><span>milk</span><span> and syrup-based formulations encouraged mice to consume tamoxifen voluntarily, but only sweetened milk formulations were statistically </span><span>non-inferior</span><span> to oral </span><span>gavage or intraperitoneal injections in inducing </span><span>CreER<sup>T2</sup>-mediated</span><span> gene expression. </span><span><span>Serum concentrations of tamoxifen metabolites, quantified using an in-house developed cell assay, confirmed the lower efficacy of syrup- as compared to sweetened milk-based formulations.</span></span> We found dosing with a micropipette to be more accurate than oral gavage or injection, with the added advantage that the method requires little training for the experimenter. <span>The new palatable solutions encourage voluntary consumption of tamoxifen without loss of </span><span>efficacy</span><span> compared to oral gavage or injections and </span><span>thus represent</span><span> </span>a refined administration method.</p>
A Study Comparing the Pharmacokinetics and Palatability of Two Candidate Pediatric Powder-for-Oral-Suspension Formulations of Maribavir to the Current Maribavir Tablet Formulation Administered in Heal
ClinicalTrials.gov study NCT04131556. IPD Sharing: NO. Countries: 1. Publications: 0.
Palatability Testing of a New Paediatric Formulation of Valacyclovir
ClinicalTrials.gov study NCT01682109. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Crossover Study to Evaluate the Relative Bioavailability and Palatability of a Lenvatinib Suspension Compared to the Capsule Formulation in Adult Healthy Volunteers
ClinicalTrials.gov study NCT02792829. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Palatability of a Novel Oral Formulation of Prednsione
ClinicalTrials.gov study NCT02233959. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Palatability Study of Five Formulations of Benzydamine HCl Lozenges
ClinicalTrials.gov study NCT07199543. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Palatability (Taste) of Oral Formulations of Bosutinib
ClinicalTrials.gov study NCT03747679. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of the Palatability and Acceptability of Different Brensocatib Oral Liquid Formulations in Healthy Participants
ClinicalTrials.gov study NCT06178783. IPD Sharing: NO. Countries: 1. Publications: 0.
Palatability of an Oral Dispersible Tablet (ODT) Formulation in Children
ClinicalTrials.gov study NCT03581799. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.