Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
5
datasets available to search
ShareScore release 0.9.0
Dataset results
5 results for “paradox of enrichment”
Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
<p>Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-derived proteomes and osteosarcoma-elevated proteins. While a conditioned medium (CM), collected from MSCs, did not present tumor-suppressing ability, the activation of PKA converted MSCs into induced tumor-suppressing cells (iTSCs). In a mouse model, the direct and hydrogel-assisted administration of CM inhibited tumor-induced bone destruction, and its effect was additive with Cisplatin. CM was enriched with proteins such as Calreticulin, which acted as an extracellular tumor suppressor by interacting with CD47. Notably, the level of Calr transcripts was elevated in OS tissues, together with other tumor-suppressing proteins, including histone H4, and PCOLCE. PCOLCE acted as an extracellular tumor-suppressing protein by interacting with amyloid precursor protein (APP), a prognostic OS marker with poor survival. The results supported the possibility of employing a paradoxical strategy of utilizing OS transcriptomes for the treatment of OS.</p>
Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins
Open the record for dataset details and reuse information.
Code and simulated data from: Overexploitation can counteract top-down control and the paradox of enrichment in simple food chains
Open the record for dataset details and reuse information.
Data from: An experimental test of the effects of dispersal and the paradox of enrichment on metapopulation persistence
Many species exhibit high-amplitude, extinction-prone cycles, for instance due to resource enrichment (called the paradox of enrichment). How do such species manage to persist? One possibility is metapopulation dynamics, but it is unclear if these can mitigate the paradox of enrichment. The paradox of enrichment might increase local population extinction rates, and might also increase the spatial synchrony of population fluctuations because population cycles are easily synchronized by even low rates of dispersal. Spatially-synchronous population fluctuations would leave no scope for rescue effects, and spatially-synchronous local extinctions would leave no source for recolonization. We conducted a protist microcosm experiment to test how dispersal and enrichment affect the persistence of predator-prey metapopulations by altering spatial synchrony. We assembled 54, 4-patch metapopulations of the protist predator Euplotes patella and its protist prey Tetrahymena pyriformis. Each metapopulation experienced one of nine dispersal rates, crossed with one of 6 enrichment levels. We tested the effects of enrichment and dispersal on predator-prey cycle amplitude, predator population extinction risk, spatial synchrony of predator population fluctuations, and predator metapopulation persistence time. Enrichment increased predator-prey cycle amplitude but had no detectable effect on population extinction risk. Dispersal had no effect on predator-prey cycle amplitude. Spatial synchrony increased with enrichment and dispersal. Metapopulation persistence decreased with enrichment and spatial synchrony. We conclude that increasing enrichment reduced metapopulation persistence primarily by increasing spatial synchrony of local extinctions, rather than by increasing their frequency. These results highlight the importance of synchrony-preventing mechanisms for metapopulation persistence.
Data from: An experimental test of the effects of dispersal and the paradox of enrichment on metapopulation persistence
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.