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Dataset results
369 results for “pathophysiology”
Unveiling Pathophysiological Insights: Serum Metabolic Dysregulation in Acute Respiratory Distress Syndrome Patients with Acute Kidney Injury
<p>The uploaded data is an Excel sheet obtained after performing the binning of 1H CPMG NMR spectra acquired using 800 MHz NMR on the serum samples of ARDS patients and ARDS with AKI patients. </p>
Identification of early genes in the pathophysiology of fibrotic interstitial lung disease in a new model of pulmonary fibrosis
<p>Some interstitial lung diseases involve pulmonary fibrosis, which is a process that is characterized by the excessive and abnormal accumulation of extracellular matrix in the pulmonary interalveolar space. Although the current anti-fibrotic therapy aims at slowing down the progression of pulmonary fibrosis, it does not reverse it, and many of the drugs that were identified in basic-research studies failed in clinical phases, mainly because of the lack of a model that can recapitulate the pathophysiological mechanisms of human pulmonary fibrosis. We developed a novel experimental model of pulmonary fibrosis induced by a cocktail of molecules on an air/liquid interface culture of mouse embryonic lung explants. Histological analyses revealed a pattern of usual interstitial pneumonia, the worst-prognosis form of pulmonary fibrosis. We performed a transcriptomics analysis at the single-cell level after the induction of fibrosis and before any histological signs of fibrosis could be observed. The results revealed increased expression of several gene families that are involved in early inflammation, fibrosis and iron homeostasis, as well as potential new genetic targets.</p> <p>This Zenodo repository includes original datasets of single cell RNA sequencing, analysis R scripts, final dataset/markers, and HTML codes for the interactive 3D UMAP and VolcanoPlot.</p>
Code. Midlife proteome-wide analysis identifies plasma biomarkers for 25-year dementia risk linked to diverse pathophysiology
<p>The code used for the analyses for the paper entitled "Midlife proteome-wide analysis identifies plasma biomarkers for 25-year dementia risk linked to diverse pathophysiology". </p>
Factors Associated With Radiographic Pathophysiology for Trapeziometacarpal Arthrosis in Patients Not Seeking Care for This Condition
ClinicalTrials.gov study NCT02252939. IPD Sharing: Not stated. Countries: 1. Publications: 16.
CRPS - Diagnostics, Pathophysiological Mechanisms, and Response to Treatment With Noninvasive Brain Stimulation
ClinicalTrials.gov study NCT04439669. IPD Sharing: NO. Countries: 1. Publications: 4.
Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
ClinicalTrials.gov study NCT03844412. IPD Sharing: YES. Countries: 1. Publications: 1.
Analysis of the Pathophysiology and Pathology of Coronavirus Disease 2019 (COVID-19), Including Chronic Morbidity
ClinicalTrials.gov study NCT04747366. IPD Sharing: NO. Countries: 1. Publications: 3.
Data from: Animal models to understand the etiology and pathophysiology in polycystic ovary syndrome
Open the record for dataset details and reuse information.
Supplementary material - Label-free multimodal nonlinear optical microscopy reveals hallmarks of bone composition in pathophysiological conditions
<p>The repository features Excel worksheets including all the data used through this work and reported in the manuscript figures and graphs. More precisely, we included the following: </p> <ul> <li>Figure 4. SHG intensity values measured from WT and KO murine spines counterparts, both in parallel and orthogonal light polarization with respect to the craniocaudal axis of the vertebrae.</li> <li>Figure 5A. Quantization of ColIa1 gene expression level after mRNA extraction from WT and Dpp3 KO mice.</li> <li>Figure 5B. Absorbance values at 540 nm after Sirius Red staining of primary osteoblast isolated from WT and Dpp3 KO neonatal calvaria, used to assess and compare the in-vitro collagen production of the two murine models.</li> <li>Figure 7. SRS intensity ratios measured between bone and bone marrow regions of WT and Dpp3 KO models, both at the 2850 cm-1 Raman mode of CH2 stretching in lipids and at the 2920 cm-1 Raman mode of CH3 stretching in proteins.</li> <li>Figure 8. Data of gene expression analysis of selected genes relevant for lipid transport, uptake, and metabolism (i.e., CD 36, Fabp4, Lrp1, Fatp1, PGC1, CPT1, Pex7 and Glut1), in the flushed bone of WT and Dpp3 KO mice.</li> </ul>
Training dataset for marmo3Dpose, related to the paper entitled "Deciphering social traits and pathophysiological conditions from natural behaviors in common marmosets"
<p>The training dataset for marmosets' 3D pose estimation developed for Kaneko and Matsumoto et al. 2024: Deciphering social traits and pathophysiological conditions from natural behaviors in common marmosets.</p> <p>Please visit</p> <p>Github: <a href="https://github.com/PrimatoModelling/marmo3Dpose">https://github.com/PrimatoModelling/marmo3Dpose</a></p> <p>Journal article: <a href="https://www.cell.com/current-biology/fulltext/S0960-9822(24)00676-6">https://www.cell.com/current-biology/fulltext/S0960-9822(24)00676-6</a></p>
Figures for the publication ''The role of small extracellular vesicles and microRNA as their cargo in the spinal cord injury pathophysiology and therapy''
Open the record for dataset details and reuse information.
Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty (THA)
ClinicalTrials.gov study NCT03759574. IPD Sharing: NO. Countries: 1. Publications: 5.
Persistent Pain After Breast Cancer Treatment (PPBCT) - Risk Factors and Pathophysiological Mechanisms
ClinicalTrials.gov study NCT01523132. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Genetic Contribution to the Pathophysiology of the Charcot Foot in Qatari Patients With Diabetes
ClinicalTrials.gov study NCT02316483. IPD Sharing: YES. Countries: 1. Publications: 1.
Hemodialysis-Induced Renal Perfusion Decline: Unraveling the Pathophysiological Mechanisms Linking Intradialytic Circulatory Stress to Residual Renal Function Loss
ClinicalTrials.gov study NCT07003828. IPD Sharing: NO. Countries: 1. Publications: 1.
Pathophysiological Explorations of Red Blood Cells
ClinicalTrials.gov study NCT03541525. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Effects and Pathophysiology of Weight Training on Pregnancy-related Pelvic Girdle Pain (PPGP)
ClinicalTrials.gov study NCT05879575. IPD Sharing: NO. Countries: 1. Publications: 24.
Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 2: 7T MRI
ClinicalTrials.gov study NCT05233306. IPD Sharing: UNDECIDED. Countries: 1. Publications: 19.
Examination of the Pathophysiologic Mechanisms of CRPS by Using QST, CPM, RIC, and Heart Rate Variability QST
ClinicalTrials.gov study NCT02261012. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pathophysiology of Inflammation After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
ClinicalTrials.gov study NCT02741167. IPD Sharing: NO. Countries: 1. Publications: 9.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.