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Dataset results
23 results for “pathway crosstalk”
Signalling pathway crosstalk stimulated by L-proline drives mouse embryonic stem cells
<p>Contains data and R code to reproduce paper models, statistics and plots</p>
Data from: Functional crosstalk across IMD and Toll pathways: insight into the evolution of incomplete immune cascades
Open the record for dataset details and reuse information.
PI3K-mediated crosstalk between angiopoietin and vascular endothelial growth factor C signaling pathways is required for lymphangiogenesis
GEO Series GSE202989. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Single-cell Transcriptome and Crosstalk Analysis Reveals Immune Alterations and Key Pathways in the Bone Marrow of Knee Osteoarthritis Patients
GEO Series GSE274018. Homo sapiens. 77 samples. Type: Expression profiling by high throughput sequencing.
Crosstalk between eIF2α and eEF2 phosphorylation pathways optimizes translational arrest in response to oxidative stress
GEO Series GSE137409. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies
GEO Series GSE168200. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
YAP mediates crosstalk between the Hippo and PI3K-TOR pathway by suppressing PTEN via miR-29
GEO Series GSE41124. Homo sapiens. 3 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Acidosis activates the Nrf2-pathway in renal proximal tubule-derived cells through a crosstalk with renal fibroblasts
GEO Series GSE218626. Rattus norvegicus. 16 samples. Type: Expression profiling by high throughput sequencing.
miR-183-5p-enriched extracellular vesicles promote the crosstalk between hepatocellular carcinoma cell and endothelial cell via SIK1/PI3K/AKT and CCL20/CCR6 signaling pathways
GEO Series GSE289187. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Crosstalk between the STAT3, NF-kB and Notch signaling pathways in glioblastoma stem cells
GEO Series GSE48079. Homo sapiens. 6 samples. Type: Expression profiling by array.
Crosstalk between EZH2 and m6A RNA methylation promotes prostate cancer progression through modulating an m6A autoregulation pathway
GEO Series GSE296858. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Cryptochrome 1 attenuates plant heat stress response by light-heat stress response signal pathways crosstalk in Arabidopsis
GEO Series GSE254813. Arabidopsis thaliana. 12 samples. Type: Expression profiling by high throughput sequencing.
Crosstalk between two bZIP signaling pathways orchestrates salt-induced metabolic reprogramming in Arabidopsis roots
GEO Series GSE71001. Arabidopsis thaliana. 24 samples. Type: Expression profiling by array.
Crosstalk from Non-Cancerous Mitochondria Can Inbibit Tumor Properties of Metastatic Cells by Suppressing Oncogenic Pathways
GEO Series GSE128610. Homo sapiens. 6 samples. Type: Expression profiling by array.
Asymmetric crosstalk between the BMP and TGFb pathways resolves signaling ambiguity
GEO Series GSE254418. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of FSH and LH dependent gene expression and the crosstalk between these two pathways in mice testes
GEO Series GSE76945. Mus musculus. 18 samples. Type: Expression profiling by array.
IMPACT: Unraveling intracellular signal transduction and pathway crosstalk by exploring pathway landscape
GEO Series GSE50564. Homo sapiens. 12 samples. Type: Expression profiling by array; Third-party reanalysis.
Bacteria-derived indole-3-lactic acid affects epithelium-macrophage crosstalk during intestinal inflammation through regulating signaling and metabolic pathways [EC]
GEO Series GSE228937. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Link to dataset related to article "The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway "
<p>Link to dataset related to article "The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway"</p> <p>Abstract</p> <p><strong>Aims: </strong> Histone H3 dimethylation at lysine 79 is a key epigenetic mark uniquely induced by methyltransferase disruptor of telomeric silencing 1-like (DOT1L). We aimed to determine whether DOT1L modulates vascular smooth muscle cell (VSMC) phenotype and how it might affect atherosclerosis in vitro and in vivo, unravelling the related mechanism.</p> <p><strong>Methods and results: </strong> Gene expression screening of VSMCs stimulated with the BB isoform of platelet-derived growth factor led us to identify Dot1l as an early up-regulated epigenetic factor. Mouse and human atherosclerotic lesions were assessed for Dot1l expression, which resulted specifically localized in the VSMC compartment. The relevance of Dot1l to atherosclerosis pathogenesis was assessed through deletion of its gene in the VSMCs via an inducible, tissue-specific knock-out mouse model crossed with the ApoE-/- high-fat diet model of atherosclerosis. We found that the inactivation of Dot1l significantly reduced the progression of the disease. By combining RNA- and H3K79me2-chromatin immunoprecipitation-sequencing, we found that DOT1L and its induced H3K79me2 mark directly regulate the transcription of Nf-κB-1 and -2, master modulators of inflammation, which in turn induce the expression of CCL5 and CXCL10, cytokines fundamentally involved in atherosclerosis development. Finally, a correlation between coronary artery disease and genetic variations in the DOT1L gene was found because specific polymorphisms are associated with increased mRNA expression.</p> <p><strong>Conclusion: </strong> DOT1L plays a key role in the epigenetic control of VSMC gene expression, leading to atherosclerosis development. Results identify DOT1L as a potential therapeutic target for vascular diseases.</p>
Genome-wide analysis of gonadotropin-dependent gene expression and crosstalk of the regulatory pathways in the female ovaries
GEO Series GSE77479. Mus musculus. 17 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.